43期

最新文章

• CD73 promotes non-small cell lung cancer metastasis by regulating Axl signaling independent of GAS6 AI翻译
  作者：Zhu, Jianjie; Du, Wenwen; Zeng, Yuanyuan; Liu, Ting; Li, Jianjun; Wang, Anqi; Li, Yue; Zhang, Weijie; Huang, Jian-an; Liu, Zeyi
  作者单位：Soochow University - China; Soochow University - China
  摘要：As catabolic enzyme, CD73 dephosphorylates adenosine monophosphate (AMP) and can also regulate tumor cell proliferation and metastasis. To date, very few studies have explored the role of CD73 in mediating non-small cell lung cancer (NSCLC) metastasis, and the underlying transducing signal has not been elucidated. In the pres- ent study, we demonstrated that the CD73/Axl axis could regulate Smad3-- induced epithelial-- to-- mesenchymal transition (EMT) to promote NSCLC metastasis. Mechanically...
• Bacterial spore surface nanoenvironment requires a AAA plus ATPase to promote MurG function AI翻译
  作者：Delerue, Thomas; Updegrove, Taylor B.; Chareyre, Sylvia; Anantharaman, Vivek; Gilmore, Michael C.; Jenkins, Lisa M.; Popham, David L.; Cava, Felipe; Aravind, L.; Ramamurthi, Kumaran S.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); Umea University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Virginia Polytechnic Institute & State University
  摘要：Bacillus subtilis spores are produced inside the cytosol of a mother cell. Spore surface assembly requires the SpoVK protein in the mother cell, but its function is unknown. Here, we report that SpoVK is a sporulation- specific, forespore- localized putative chaperone from a distinct higher- order clade of AAA+ ATPases that promotes the peptidoglycan glycosyltransferase activity of MurG during sporulation, even though MurG does not normally require activation during vegetative growth. MurG red...
• We need to understand when not if generative AI can enhance personalized persuasion AI翻译
  作者：Teeny, Jacob D.; Matz, Sandra C.
  作者单位：Northwestern University; Columbia University
• Self- views converge during enjoyable conversations AI翻译
  作者：Welker, Christopher; Wheatley, Thalia; Cason, Grace; Gorman, Catherine; Meyer, Meghan
  作者单位：Dartmouth College; The Santa Fe Institute; Columbia University
  摘要：Based on current research, it is evident that the way people see themselves is shaped by their conversation partners. Historically, this literature focuses on how one individual's expectations can shape another person's self- views. Given the reciprocal nature of conversation, we wondered whether conversation partners' self- views may mutually evolve. Using four- person round- robin conversation networks, we found that participants tended to have more similar self- views post- conversation tha...
• Temporal covariation of island arc Sr isotopes and seawater chemistry over the past 2 billion years AI翻译
  作者：Bednarick, Amanda L.; Bucholz, Claire E.; Depaolo, Donald J.; Stolper, Daniel A.
  作者单位：California Institute of Technology; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The chemical compositions of island arc basalts (IAB) reflect contributions from the mantle as well as fluids and melts from the subducting slab. Addition of radiogenic seawater Sr to oceanic crust through hydrothermal alteration and subsequent subduction is often invoked to explain elevated 87 Sr/ 86 Sr signatures in modern IAB. However, changes in the 87 Sr/ 86 Sr of island arc magmatic rocks through time has not been investigated, limiting our understanding of the factors influencing the Sr...
• Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre-tRNA cleavage AI翻译
  作者：Liang, Xiaoge; Chen, Dian; Su, Aimin; Liu, Yu
  作者单位：Shanghai Jiao Tong University
  摘要：Ribonuclease P (RNase P) plays a vital role in the maturation of tRNA across bacteria, archaea, and eukaryotes. However, how RNase P assembles various components to achieve specific cleavage of precursor tRNA (pre-tRNA) in different organisms remains elusive. In this study, we employed single- molecule fluorescence resonance energy transfer to probe the dynamics of RNase P from E. coli ( Escherichia coli) and Mja ( Methanocaldococcus jannaschii) during pre-tRNA cleavage by incorporating five C...
• Cobalt-based pyroxenes: A new playground for Kitaev physics AI翻译
  作者：Maksimov, Pavel A.; Ushakov, Alexey, V; Gubkin, Andrey F.; Redhammer, Guenther J.; Winter, Stephen M.; Kolesnikov, Alexander I.; Santos, Antonio M. dos; Gai, Zheng; Mcguire, Michael A.; Podlesnyak, Andrey; Streltsov, Sergey, V
  作者单位：Joint Institute for Nuclear Research - Russia; Russian Academy of Sciences; Institute of Metal Physics UB RAS; Ural Federal University; Salzburg University; Wake Forest University; Wake Forest University; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences; United States Department of Energy (DOE); Oak Ridge National Laboratory; Ural Federal University
  摘要：Recent advances in the study of cobaltites have unveiled their potential as a promising platform for realizing Kitaev physics in honeycomb systems and the Ising model in weakly coupled chain materials. In this manuscript, we explore the magnetic properties of pyroxene SrCoGe2O6 using a combination of neutron scattering, ab initio methods, and linear spin-wave theory. Through careful examination of inelastic neutron scattering powder spectra, we propose a modified Kitaev model to accurately des...
• Contextualizing racial associations in gene expression in patients with uterine serous carcinoma AI翻译
  作者：Rollin, Francois G.; Patel, Shree A.; McCachren, Samuel S.
  作者单位：Emory University; Emory University
• Free radical detection in precision- cut mouse liver slices with diamond- based quantum sensing AI翻译
  作者：Zhang, Yue; Sigaeva, Alina; Elias-Llumbet, Arturo; Fan, Siyu; Woudstra, Willem; de Boer, Rinse; Escobar, Elkin; Reyes-San-Martin, Claudia; Kisabacak, Robin; Oosterhuis, Dorenda; Gorter, Alan R.; Coenen, Britt; Martinez, Felipe P. Perona; van den Bogaart, Geert; Olinga, Peter; Schirhagl, Romana
  作者单位：University of Groningen; Universidad de Chile; University of Groningen; Universidad de Antioquia
  摘要：Free radical generation plays a key role in many biological processes including cell communication, maturation, and aging. In addition, free radical generation is usually elevated in cells under stress as is the case for many different pathological conditions. In liver tissue, cells produce radicals when exposed to toxic substances but also, for instance, in cancer, alcoholic liver disease and liver cirrhosis. However, free radicals are small, short- lived, and occur in low abundance making th...
• Science offers the best way of knowing-as long as we don't confuse what is with what ought to be AI翻译
  作者：Doolittle, W. Ford
  作者单位：Dalhousie University; Dalhousie University