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作者：Gu, Xiaosong; Feng, Xuezhen; Yang, Songhe; Wang, Ranhao; Zeng, Qiang; Shangguan, Yangzi; Liang, Jiaxin; Zhou, Huiling; Li, Zhiwei; Lin, Zhang; Zheng, Chunmiao; Xu, Zhenghe; Chen, Hong
作者单位：Southern University of Science & Technology; Central South University; Eastern Institute of Technology, Ningbo; Eastern Institute for Advanced Study; Southern University of Science & Technology
摘要：The insatiable demand for lithium in portable energy storage necessitates a sustainable and low- carbon approach to its recovery. Conventional hydrometallurgical and pyrometallurgical methods heavily involve hazardous chemicals and significant CO2 emissions. Herein, by integrating electrode oxidation with electrolyte oxidation, we establish a photovoltaic- driven dual- oxidation seawater electrolyzer system for low- carbon footprint and high lithium recovery. A 98.96% lithium leaching rate wit...
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作者：Li, Wan; Zhou, Jing; Gu, Yang; Chen, Yuheng; Huang, Yiming; Yang, Jingxin; Zhu, Xiaojuan; Zhao, Kangchen; Yan, Qin; Zhao, Zongzheng; Li, Xiao; Chen, Guochun; Jia, Xuemei; Gao, Shou-Jiang; Lu, Chun
作者单位：Nanjing Medical University; Nanjing Medical University; Nanjing Medical University; Jiangsu Provincial Center for Disease Control & Prevention; Chinese Academy of Agricultural Sciences; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：RNA N 6- methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) plays a crucial role in regulating innate immunity. Lysine acylation, a widespread protein modification, influences protein function, but its impact on ALKBH5 during viral infections has not been well characterized. This study investigates the presence and regulatory mechanisms of a previously unidentified lysine acylation in ALKBH5 and its role in mediating m6A modifications to activate antiviral innate immune responses. We de...
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作者：McDonald, Angus; Murre, Cornelis; Sedat, John W.
作者单位：Boise State University; University of California System; University of California San Diego; University of California System; University of California San Francisco
摘要：Recent studies showed an interphase chromosome architecture-a specific coiled nucleosome structure-derived from cryopreserved EM tomograms, and dispersed throughout the nucleus. The images were computationally processed to fill in the missing wedges of data caused by incomplete tomographic tilts. The resulting structures increased z- resolution enabling an extension of the proposed architecture to that of mitotic chromosomes. Here, we provide additional insights into the chromosome architectur...
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作者：Paiardi, Giulia; Ferraz, Matheus; Rusnati, Marco; Wade, Rebecca C.
作者单位：Heidelberg Institute for Theoretical Studies; Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Fundacao Oswaldo Cruz; Universidade Federal de Pernambuco; Ruprecht Karls University Heidelberg
摘要：Although it is well established that the SARS-CoV-2 spike glycoprotein binds to the host cell ACE2 receptor to initiate infection, far less is known about the tissue tropism and host cell susceptibility to the virus. Differential expression across different cell types of heparan sulfate (HS) proteoglycans, with variably sulfated glycosaminoglycans (GAGs), and their synergistic interactions with host and viral N- glycans may contribute to tissue tropism and host cell susceptibility. Nevertheles...
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作者：Abdullayeva, Gulnar; Liu, Haoyu; Liu, Ta- Chun; Simmons, Alison; Novelli, Marco; Huseynova, Irada; Lastun, Viorica L.; Bodmer, Walter
作者单位：University of Oxford; University of Oxford; Tencent; University of Oxford; University of Oxford; University of London; University College London
摘要：The poor prognosis of relatively undifferentiated cancers has long been recognized, suggesting that selection against differentiation and in favor of uncontrolled growth is one of the most powerful drivers of cancer progression. Goblet cells provide the mucous surface of the gut, and when present in colorectal cancers (CRC), the cancers are called mucinous. We have used the presence of MUC2, the main mucous product of goblet cells, and an associated gene product, TFF3, to classify a large pane...
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作者：Ding, Liuyang; Sabidussi, Lena F.; Holloway, Brian C.; Hultmark, Marcus; Smits, Alexander J.
作者单位：Princeton University; Intellectual Ventures
摘要：A turbulent pipe flow experiment was conducted where the surface of the pipe was oscillated azimuthally over a wide range of frequencies, amplitudes, and Reynolds numbers. The drag was reduced by as much as 35%. Past work has suggested that the drag reduction scales with the velocity amplitude of the motion, its period, and/or the Reynolds number. Here, we find that the key parameter is the acceleration, which greatly simplifies the complexity of the phenomenon. This result is shown to apply t...
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作者：Lacoste, Baptiste
作者单位：University of Ottawa; Ottawa Hospital Research Institute; University of Ottawa; University of Ottawa
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作者：Yang, Yi-Heng; Xie, Ke-Fang; Yang, Shuai; Wang, Huan; Ma, Hui-Hui; Zhou, Min; Wang, Zhong-Wei; Gu, Yebo; Jia, Xin-Ming
作者单位：Tongji University; Tongji University; China Pharmaceutical University; Tongji University; Tongji University
摘要：B cell linker protein (BLNK) is crucial for orchestrating B cell receptor- associated spleen tyrosine kinase (Syk) signaling. However, the role of BLNK in Syk- coupled C- type lectin receptor (CLR) signaling in macrophages remains unclear. Here, we delineate that CLRs govern the Syk- mediated activation of BLNK, thereby impeding macrophage migration by disrupting podosome ring formation upon stimulation with fungal beta- glucans or alpha- mannans. Mechanistically, BLNK instigates its associati...
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作者：Davis, Andrew K.; Croy, Jordan R.; Snyder, William E.
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
摘要：The conservation status of monarch butterflies in North America is a topic of intense scrutiny and debate. It is clear that winter colonies in Mexico are declining, yet some recent studies suggest that summer breeding populations are relatively stable and similar to historical abundances. One possible explanation for these discordant patterns is that fall migration success has been recently disrupted. Here, we use a relatively unexplored citizen- scientist dataset on the size of monarch roosts...
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作者：Ma, Anyi; Paek, Jessica J. W.; Liu, Fangzhou; Kim, Jae Yun
作者单位：University of Wisconsin System; University of Wisconsin Madison; Indiana University System; IU Kelley School of Business; Indiana University Bloomington; Huazhong University of Science & Technology; University of Manitoba
摘要：We propose that experiencing a lack of personal control will increase people's preferences for self- similar others and that this effect would be explained by a greater need for structure. Our hypotheses received support across 11 longitudinal, experimental, and archival studies composed of data from 60 countries (5 preregistered studies, N = 90,216). In an analysis of cross- country archival data, we found that respondents who indicated a lower sense of personal control were less likely to pr...
