43期

最新文章

• KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling AI翻译
  作者：Liao, Yini; Muntean, Brian S.
  作者单位：University System of Georgia; Augusta University
  摘要：Dopamine transfers information to striatal neurons, and disrupted neurotransmission leads to motor deficits observed in movement disorders. Striatal dopamine converges the essential role of signal transduction in motor physiology. However, the relationship between dopamine decoding and AC5 regulation is unknown. Here, we utilized an unbiased global protein stability screen to identify Potassium Channel Tetramerization Domain 1 (KCTD1) as a key regulator of AC5 level that is mechanistically tie...
• Programmable heterogeneous lamellar lattice architecture for dual mechanical protection AI翻译
  作者：Tian, Yuanyuan; Zhang, Xin; Hou, Boyuan; Jarlov, Asker; Du, Chunyang; Zhou, Kun
  作者单位：Nanyang Technological University; Singapore Centre for 3D Printing; Nanyang Technological University; Northwestern Polytechnical University; National University of Defense Technology - China
  摘要：Shear bands frequently appear in lattice architectures subjected to compression, leading to an unstable stress-strain curve and global deformation. This deformation mechanism reduces their energy absorption and loading- bearing capacity and causes the architectures to prioritize mechanical protection of external components at the expense of the entire structure. Here, we leverage the design freedom offered by additive manufacturing and the geometrical relation of dual- phase nanolamellar cryst...
• Health benefits of US light- duty vehicle electrification: Roles of fleet dynamics, clean electricity, and policy timing AI翻译
  作者：Schmitt, Jean; Hatzopoulou, Marianne; Abdul-Manan, Amir F. N.; MacLean, Heather L.; Posen, I. Daniel
  作者单位：University of Toronto
  摘要：We present a dynamic perspective to quantify the air quality-related health impacts of the electrification of light- duty vehicles in the United States between 2022 and 2050. Using a fleet turnover model and future electricity generation mix scenarios, we compare ambitious vehicle electrification to fleet renewal relying on newer internal combustion engine vehicles, without electric vehicles. The model includes vehicle- level pollutant emission factors and a reduced complexity air quality and ...
• Unraveling abiotic organic synthesis pathways in the mafic crust of mid- ocean ridges AI翻译
  作者：Nan, Jingbo; Peng, Xiaotong; Plumper, Oliver; ten Have, Iris C.; Lu, Jing- Guang; Liu, Qian-Bao; Li, Shao-Lin; Hu, Yingjie; Liu, Yu; Shen, Zhen; Yao, Weiqi; Tao, Renbiao; Preiner, Martina; Luo, Yongxiang
  作者单位：Chinese Academy of Sciences; Institute of Deep-Sea Science & Engineering, CAS; Chinese Academy of Sciences; Utrecht University; Utrecht University; Macau University of Science & Technology; Macau University of Science & Technology; Nanjing Xiaozhuang University; China University of Mining & Technology; Southern University of Science & Technology; Max Planck Society; Philipps University Marburg; Max Planck Society
  摘要：The aqueous alteration of the oceanic lithosphere provides significant energy that impacts the synthesis and diversity of organic compounds, which are crucial for the deep carbon cycle and may have provided the first building blocks for life. Although abiotic organic synthesis has been documented in mantle- derived rocks, the formation mechanisms and complexity of organic compounds in crustal rocks remain largely unknown. Here, we show the specific association of aliphatic carbonaceous matter ...
• Manipulating a host- native microbial strain compensates for low microbial diversity by increasing weight gain in a wild bird population AI翻译
  作者：Somers, Shane E.; Davidson, Gabrielle L.; Mbandlwa, Philiswa; Mckeon, Caroline M.; Stanton, Catherine; Ross, R. Paul; Quinn, John L.
  作者单位：University College Cork; University College Cork; University of East Anglia; Teagasc; Agri-Food & Biosciences Institute; Trinity College Dublin; University College Cork
  摘要：Empirical studies from laboratory systems and humans show that the gut microbiota is linked to host health. Similar evidence for effects on traits linked to fitness in nature is rare, not least because experimentally manipulating the gut microbiota is challenging. We isolated, characterized, and cultured a bacterial strain, Lactobacillus kimchicus APC4233, directly from a wild bird (the great tit Parus major) and provided it as a self- administered dietary supplement. We assessed the impact of...
• Thermomechanical properties of bat and human red blood cells-Implications for hibernation AI翻译
  作者：Fregin, Bob; Hossain, Mohammed Faruq; Biedenweg, Doreen; Friedrichs, Virginia; Balkema-Buschmann, Anne; Bokelmann, Marcel; Lehnert, Kristin; Mokbel, Dominic; Aland, Sebastian; Scholz, Carsten C.; Lehmann, Philipp; Otto, Oliver; Kerth, Gerald
  作者单位：Universitat Greifswald; German Centre for Cardiovascular Research; Universitat Greifswald; Greifswald Medical School; Friedrich Loeffler Institute; Universitat Greifswald; Greifswald Medical School; Technical University Freiberg; Universitat Greifswald; Greifswald Medical School; Universitat Greifswald; Universitat Greifswald
  摘要：Hibernation is a widespread and highly efficient mechanism to save energy in mammals. However, one major challenge of hibernation is maintaining blood circulation at low body temperatures, which strongly depends on the viscoelastic properties of red blood cells (RBCs). Here, we examined at physiologically relevant timescales the thermomechanical properties of hundreds of thousands of individual RBCs from the hibernating common noctule bat ( Nyctalus noctula), the nonhibernating Egyptian fruit ...
• Dramatic changes in mitochondrial subcellular location and morphology accompany activation of the CO2 concentrating mechanism AI翻译
  作者：Findinier, Justin; Joubert, Lydia - Marie; Fakhimi, Neda; Schmid, Michael F.; Malkovskiy, Andrey, V; Chiu, Wah; Burlacot, Adrien; Grossman, Arthur R.
  作者单位：Carnegie Institution for Science; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University
  摘要：Dynamic changes in intracellular ultrastructure can be critical for the ability of organisms to acclimate to environmental conditions. Microalgae, which are responsible for similar to 50% of global photosynthesis, compartmentalize their Ribulose 1,5 Bisphosphate Carboxylase/Oxygenase (Rubisco) into a specialized structure known as the pyrenoid when the cells experience limiting CO2 conditions; this compartmentalization is a component of the CO2 Concentrating Mechanism (CCM), which facilitates ...
• Reply to Teeny and Matz: Toward the robust measurement of personalized persuasion with generative AI AI翻译
  作者：Hackenburg, Kobi; Margetts, Helen
  作者单位：University of Oxford
• Evolutionary origins of the lysosome-related organelle sorting machinery reveal ancient homology in post-endosome trafficking pathways AI翻译
  作者：More, Kiran J.; Kaufman, Jonathan G. G.; Dacks, Joel B.; Manna, Paul T.
  作者单位：University of Alberta; University of Alberta; University of Cambridge; University of London; University College London; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; University of Gothenburg
  摘要：The major organelles of the endomembrane system were in place by the time of the last eukaryotic common ancestor (LECA) (similar to 1.5 billion years ago). Their acquisitions were defining milestones during eukaryogenesis. Comparative cell biology and evolutionary analyses show multiple instances of homology in the protein machinery controlling distinct interorganelle trafficking routes. Resolving these homologous relationships allows us to explore processes underlying the emergence of additio...
• Modeling the population-level impact of a third dose of MMR vaccine on a mumps outbreak at the University of Iowa AI翻译
  作者：Park, Sang Woo; Lawal, Tomi; Marin, Mona; Marlow, Mariel A.; Grenfell, Bryan T.; Masters, Nina B.
  作者单位：Princeton University; Centers for Disease Control & Prevention - USA
  摘要：Mumps outbreaks among fully vaccinated young adults have raised questions about potential waning of immunity over time and need for a third dose of the measles, mumps, rubella (MMR) vaccine. However, there are currently limited data on real-life effectiveness of the third-dose MMR vaccine in preventing mumps. Here, we used a deterministic compartmental model to infer the effectiveness of the third-dose MMR vaccine in preventing mumps cases by analyzing the mumps outbreak that occurred at the U...