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作者：Sobral, Miguel C.; Cabizzosu, Laura; Kang, Shawn J.; Ruark, Kyle; Najibi, Alex J.; Lane, Ryan S.; Vitner, Einat; Ijaz, Hamza; Dellacherie, Maxence O.; Dacus, Mason T.; Tringides, Christina M.; de Lazaro, Irene; Pittet, Mikael J.; Mueller, Soeren; Turley, Shannon J.; Mooney, David J.
作者单位：Harvard University; Harvard University; Roche Holding; Roche Holding USA; Genentech; Harvard University; University of Geneva; Ludwig Institute for Cancer Research; University of California System; University of California San Francisco
摘要：One driver of the high failure rates of clinical trials for therapeutic cancer vaccines is likely the inability to sufficiently engage conventional dendritic cells (cDCs), the antigen-presenting cell (APC) subset that is specialized in priming antitumor T cells. Here, we demonstrate that, relative to vaccination with an injectable mesoporous silica rod (MPS) vaccine alone (Vax), combining MPS vaccines with CD122-biased IL-2/anti-IL-2 antibody complexes (IL-2cx) drives similar to 3-fold expansi...
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作者：Kohrt, Sarah E.; Novak, Emily J.; Tapadar, Subhashish; Wu, Bocheng; Strope, Jonathan; Strope, Jonathan; Asante, Yaw; Kim, Hyunmin; Chang, Matthew S.; Gurdak, Douglas; Khalil, Athar; Rood, Michael; Raftery, Eric; Stavreva, Diana; Nguyen, Holly M.; Brown, Lisha G.; Ramser, Maddy; Peer, Cody; Meyers, Warren M.; Aboreden, Nicholas; Chakravortee, Maharshi; Sallari, Richard; Nelson, Peter S.; Kelly, Kathleen K.; Graham, Thomas G. W.; Darzacq, Xavier; Figg, William D.; Oyelere, Adegboyega K.; Corey, Eva; Ogala, Remi Adelaiye --; Gryder, Berkley E.
作者单位：University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Georgia; Georgia Institute of Technology; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Washington; University of Washington Seattle; University of British Columbia; University of Pennsylvania; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of California System; University of California Berkeley; State University of New York (SUNY) System; University at Buffalo, SUNY
摘要：Sustained androgen receptor (AR) signaling during relapse is a central driver of metastatic castration- resistant prostate cancer (mCRPC). Current AR antagonists, such as enzalutamide, fail to provide long- term benefit for the mCRPC patients who have dramatic increases in AR expression. Here, we report AR antagonists with efficacy in AR- overexpressing models. These molecules bind to the ligand- binding domain of the AR, promote AR localization to the nucleus, yet potently and selectively dow...
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作者：Tang, Xianglin; Mei, Yuanyuan; He, Kaixuan; Liu, Ran; Lv, Xiaoyan; Zhao, Yujia; Li, Wenjing; Wang, Qian; Gong, Qinshan; Li, Shengnan; Xu, Chang; Zheng, Xu; Cao, Qingyu; Wang, Dan; Wang, Ning Ning
作者单位：Nankai University
摘要：Ethylene is widely recognized as a positive regulator of leaf senescence. However, how plants coordinate the biosynthesis of ethylene to meet the requirements of senescence progression has not been determined. The rate- limiting enzyme in the ethylene biosynthesis pathway is ACC synthase. AtACS7 was previously considered one of the major contributors to the synthesis of senescence ethylene in Arabidopsis. However, the brake signal that fine- tunes the expression of AtACS7 to ensure optimal eth...
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作者：Vereertbrugghen, Alexia; Pizzano, Manuela; Cernutto, Agostina; Sabbione, Florencia; Keitelman, Irene A.; Aguilar, Douglas Vera; Podhorzer, Ariel; Fuentes, Federico; Corral-Vazquez, Celia; Guzman, Mauricio; Giordano, Mirta N.; de Paiva, Cintia S.; Downie, Laura E.; Nathans, Jeremy
作者单位：Buenos Aires National Academy of Medicine; Buenos Aires National Academy of Medicine; Buenos Aires National Academy of Medicine; Hospital del Mar Research Institute; Hospital del Mar; Baylor College of Medicine
摘要：Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal epithelium and its abundant nerves are affected by ocular desiccation and inflammation. Although adaptive immunity and specifically CD4(+ )T cells play a role in DED pathogenesis, the exact contribution of these cells to corneal epithelial and neural damage remains undetermined. To address this, we explored the progression of a surgical DED model in wild- type (WT) and T cell- deficient mice. We observed t...
