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作者：Jiao, Alan L.; Sendinc, Erdem; Zee, Barry M.; Wallner, Felice; Shi, Yang
作者单位：University of Oxford; Ludwig Institute for Cancer Research; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Cell Signaling Technology
摘要：The H3K27M oncogenic histone (oncohistone) mutation drives similar to 80% of incurable childhood brain tumors known as diffuse midline gliomas (DMGs). The major molecular feature of H3K27M mutant DMGs is a global loss of H3K27 trimethylation (H3K27me3), a phenotype conserved in Caenorhabditis elegans (C. elegans). Here, we perform unbiased genome-wide suppressor screens in C. elegans expressing H3K27M and isolate 20 suppressors, all of which at least partially restore H3K27me3. 19/20 suppresso...
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作者：Teixeira, Rodrigo Braz; Carugno, Giorgio; Neri, Izaak; Sartori, Pablo
作者单位：Universidade de Lisboa; University of London; King's College London
摘要：Biological mixtures, such as the cellular cytoplasm, are composed of a large number of different components. From this heterogeneity, ordered mesoscopic structures emerge, such as liquid phases with controlled composition. The competition of these structures for the same components raises several questions: what types of interactions allow the retrieval of multiple ordered mesoscopic structures, and what are the physical limitations for the retrieval of said structures. In this work, we develo...
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作者：Baym, Gordon; Peng, Jen-Chieh; Pethick, C. J.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Copenhagen; Niels Bohr Institute; Royal Institute of Technology; Nordic Institute for Theoretical Physics; Stockholm University
摘要：We ask the question of how angular momentum is conserved in electroweak interaction processes. To introduce the problem with a minimum of mathematics, we first raise the same issue in elastic scattering of a circularly polarized photon by an atom, where the scattered photon has a different spin direction than the original photon, and note its presence in scattering of a fully relativistic spin-1/2 particle by a central potential. We then consider inverse beta decay in which an electron is emit...
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作者：Gardner, Jennifer Lyon; Stoddart, Chasmine; Wigginton, Nicholas S.
作者单位：University of Texas System; University of Texas Austin; Johns Hopkins University; University of Michigan System; University of Michigan
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作者：Hiramoto, Masaki; Cline, Hollis T.
作者单位：Scripps Research Institute
摘要：Natural visual scenes are dominated by spatiotemporal image dynamics, but how the visual system integrates movie information over time is unclear. We characterized optic tectal neuronal receptive fields using sparse noise stimuli and reverse correlation analysis. Neurons recognized movies of similar to 200- 600 ms durations with defined start and stop stimuli. Movie durations from start to stop responses were tuned by sensory experience though a hierarchical algorithm. Neurons encoded families...
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作者：Kantor, Asher M.; Talyuli, Octavio A. C.; Reid, William R.; Alvarenga, Patricia Hessab; Booker, Jasmine; Lin, Jingyi; Franz, Alexander W. E.; Barillas, Carolina
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of Missouri System; University of Missouri Columbia
摘要：The establishment of a productive dengue virus (DENV) infection in the midgut epithelial cells of Aedes aegypti is critical for the viral transmission cycle. The hypothesis that DENVvirions interact directly with specific mosquito midgut proteins was explored. We found that DENV serotype 2 (DENV2) pretreated with trypsin interacted with a single 31 kDa protein, identified as AAEL011180 by protein mass spectrometry. This putative receptor is a highly conserved protein and has orthologs in culic...
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作者：Lazou, Maria; Khan, Omeir; Nguyen, Thu; Padhorny, Dzmitry; Kozakov, Dima; Mccarthy, Diane Joseph -; Vajda, Sandor
作者单位：Boston University; Boston University; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University
摘要：The goal of this paper is predicting the conformational distributions of ligand binding sites using the AlphaFold2 (AF2) protein structure prediction program with stochastic subsampling of the multiple sequence alignment (MSA). We explored the opening of cryptic ligand binding sites in 16 proteins, where the closed and open conformations define the expected extreme points of the conformational variation. Due to the many structures of these proteins in the Protein Data Bank (PDB), we were able ...
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作者：Murase, Yohsuke; Hilbe, Christian
作者单位：RIKEN; Max Planck Society
摘要：Indirect reciprocity is a key explanation for the exceptional magnitude of cooperation among humans. This literature suggests that a large proportion of human cooperation is driven by social norms and individuals' incentives to maintain a good reputation. This intuition has been formalized with two types of models. In public assessment models, all community members are assumed to agree on each others' reputations; in private assessment models, people may have disagreements. Both types of model...
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作者：Edwards, Charles T. T.; Gobush, Kathleen S.; Maisels, Fiona; Balfour, Dave; Taylor, Russell; Wittemyer, George
作者单位：University of Washington; University of Washington Seattle; Wildlife Conservation Society; University of Stirling; Nelson Mandela University; Colorado State University System; Colorado State University Fort Collins
摘要：of conservation status, which in turn is critical for planning and targeting management interventions. However, monitoring effort and methodologies can change over the assessment period, resulting in heterogeneous data that are difficult to interpret. Here, we develop a hierarchical, random effects Bayesian model to estimate sitelevel trends in density of African elephants from geographically disparate survey data. The approach treats the density trend per site as a random effect and estimates...
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作者：Kashyap, Mahendra Pratap; Mishra, Bharat; Sinha, Rajesh; Jin, Lin; Gou, Yifei; Kumar, Nilesh; Goliwas, Kayla F.; Haque, Safiya; Deshane, Jessy; Berglund, Erik; Berglund, David; Elewski, Boni E.; Elmets, Craig A.; Athar, Mohammad; Mukhtar, M. Shahid; Raman, Chander
作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Uppsala University; Clemson University
摘要：Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with a poorly understood immunopathogenesis. Here, we report that HS lesional skin is characterized by the expansion of innate lymphocytes and T cells expressing CD2, an essential activation receptor and adhesion molecule. Lymphocytes expressing elevated CD2 predominated with unique spatial distribution throughout the epidermis and hypodermis in the HS lesion. CD2+ cells were mainly innate lymphocytes expressing...
