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作者：Barone, Benedetto
作者单位：University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa
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作者：Du, Samuel W.; Newby, Gregory A.; Salom, David; Gao, Fangyuan; Menezes, Carolline Rodrigues; Suh, Susie; Choi, Elliot H.; Chen, Paul Z.; Liu, David R.; Palczewski, Krzysztof
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Johns Hopkins University; Johns Hopkins University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：Rhodopsin, the prototypical class- A G- protein coupled receptor, is a highly sensitive receptor for light that enables phototransduction in rod photoreceptors. Rhodopsin plays not only a sensory role but also a structural role as a major component of the rod outer segment disc, comprising over 90% of the protein content of the disc membrane. Mutations in RHO which lead to structural or functional abnormalities, including the autosomal recessive E150K mutation, result in rod dysfunction and de...
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作者：Hou, Qiang; Wei, Wei; Zhou, Xin; Liu, Wenhui; Wang, Ke; Xing, Xiangzhuo; Zhang, Yufeng; Zhou, Nan; Pan, Yongqiang; Sun, Yue; Shi, Zhixiang
作者单位：Southeast University - China; Qufu Normal University; Jiangsu University; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS
摘要：Recent investigations of FeSe-based superconductors have revealed the presence of two superconducting domes and suggest possible distinct pairing mechanisms. Two superconducting domes are commonly found in unconventional superconductors and exhibit unique normal states and electronic structures. In this study, we conducted electromagnetic transport measurements to establish a complete phase diagram, successfully observing the two superconducting domes in FeSe1-xSx (0 <= x <= 0.25) and FeSe1-xT...
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作者：Pomara, Nunzio; Osorio, Ricardo; Plaska, Chelsea Reichert; Imbimbo, Bruno Pietro
作者单位：Nathan Kline Institute for Psychiatric Research; New York University; New York University; Nathan Kline Institute for Psychiatric Research; Chiesi Pharmaceuticals Inc
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作者：Aksel, Tural; Navarro, Erik J.; Fong, Nicholas; Douglas, Shawn M.
作者单位：University of California System; University of California San Francisco
摘要：We describe design principles for accurate folding of three- dimensional DNA origami. To evaluate design rules, we reduced the problem of DNA strand routing to the known problem of shortest- path finding in a weighted graph. To score candidate DNA strand routes we used a thermodynamic model that accounts for enthalpic and entropic contributions of initial binding, hybridization, and DNA loop closure. We encoded and analyzed new and previously reported design heuristics. Using design principles...
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作者：Coelho, Camila Galheigo; Garcia-Nisa, Ivan; Ottoni, Eduardo B.; Kendal, Rachel L.
作者单位：Durham University; Universidade de Sao Paulo
摘要：The last two decades have seen great advances in the study of social learning (learning from others), in part due to efforts to identify it in the wild as the basis of behavioral traditions. Theoretical frameworks suggest that both the dynamics of social tolerance and transmission biases (or social learning strategies) influence the pathways of information diffusion in social groups. Bearded capuchins ( Sapajus libidinosus) inhabiting the semiarid seasonal caatinga biome of the Serra da Capiva...
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作者：Ladak, Reese Jalal; Choi, Jung - Hyun; Luo, Jun; Chen, Owen J.; Mahmood, Niaz; He, Alexander J.; Naeli, Parisa; Snell, Patric Harris; Bayani, Esha; Hoang, Huy - Dung; Alain, Tommy; Teodoro, Jose G.; Wang, Jianwei; Zhang, Xu; Jafarnejad, Seyed Mehdi; Sonenberg, Nahum
作者单位：McGill University; McGill University; Queens University Belfast; McGill University; University of Ottawa; Children's Hospital of Eastern Ontario; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：A critical host response against viral infections entails the activation of innate immune signaling that culminates in the production of antiviral proteins. DNA viruses are sensed by the cytosolic pattern recognition receptor cyclic GMP-AMP synthase (cGAS), which initiates a signaling pathway that results in production of proinflammatory cytokines such as Interferon-beta (IFN- beta ) and activation of the antiviral response. Precise regulation of the antiviral innate immune response is require...
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作者：Materic, Dusan
作者单位：Helmholtz Association; Helmholtz Center for Environmental Research (UFZ)
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作者：Mcwilliams, James C.
作者单位：University of California System; University of California Los Angeles
摘要：In response to a recent challenge to the longstanding practice in modeling large-scale circulations in the atmosphere and ocean that neglects any horizontal component of Earth's gravity-rotation force, this paper demonstrates that a coordinate transformation into geopotential coordinates has no such horizontal force. This framework should be understood as the justification for and, if warranted, the basis for making further refinements to such geophysical models.
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作者：Wei, Zongbo; Hao, Caili; Radeen, Kazi Rafsan; Hao, Zheng; Kettimuthu, Kavitha; Maner-Smith, Kristal; Toyokuni, Shinya; Fan, Xingjun
作者单位：University System of Georgia; Augusta University; Nagoya University; Emory University
摘要：The human lens is composed of a monolayer of lens epithelial cells (LECs) and elongated fibers that align tightly but are separated by the plasma membrane. The integrity of the lens plasma membrane is crucial for maintaining lens cellular structure, homeostasis, and transparency. Glutathione peroxidase 4 (GPX4), a selenoenzyme, plays a critical role in protecting against lipid peroxidation. This study aims to elucidate the role of GPX4 in lens plasma membrane stability during lens development ...
