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作者：Kammer, Kai-Michael; Eisgruber, Terese; Heid, Peter; Pellarin, Riccardo; Stengel, Florian
作者单位：University of Konstanz; University of Konstanz; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：Proteins play a central role in most biological processes within the cell, and deciphering how they interact is key to understand their function. Cross- linking coupled with mass spectrometry is an essential tool for elucidating protein-protein interactions (PPIs). Despite its importance, we still know surprisingly little about the principles that underlie the process of chemical cross- link formation itself and how it is influenced by different physicochemical factors. To understand the molec...
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作者：Woodie, Lauren N.; Alberto, Ahren J.; Krusen, Brianna M.; Melink, Lily C.; Lazar, Mitchell A.
作者单位：University of Pennsylvania
摘要：Nearly every cell of the body contains a circadian clock mechanism that is synchronized with the light- entrained clock in the suprachiasmatic nucleus (SCN). Desynchrony between the SCN and the external environment leads to metabolic dysfunction in shift workers. Similarly, mice with markedly shortened endogenous period due to the deletion of circadian REV- ERB alpha/beta nuclear receptors in the SCN (SCN DKO) exhibit increased sensitivity to diet- induced obesity (DIO) on a 24 h light:dark cy...
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作者：Bing, Lindsay; Goldstein, Rebecca; Ho, Helen; Pager, Devah; Western, Bruce
作者单位：University of Alberta; University of California System; University of California Berkeley; Harvard University; Columbia University
摘要：US courts regularly assess fines, fees, and costs against criminal defendants. Court- related debt can cause continuing court involvement and incarceration, not because of new crimes, but because of unpaid financial obligations. We conducted an experiment with 606 people found guilty of misdemeanors in Oklahoma County, Oklahoma. Study participants were randomly selected to receive relief from all current and prior fines and fees assessed for criminal charges in the county. Fee relief reduced j...
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作者：Cui, Yan-Hong; Wei, Jiangbo; Fan, Hao; Li, Wenlong; Zhao, Lijie; Wilkinson, Emma; Peterson, Jack; Xie, Lishi; Zou, Zhongyu; Yang, Seungwon; Applebaum, Mark A.; Kline, Justin; Chen, Jing; He, Chuan; He, Yu-Ying
作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago; University of Chicago; Howard Hughes Medical Institute
摘要：Here, we show that vitamin E succinate (VES) acts as a degrader for the m6A RNA demethylase fat mass and obesity- associated protein (FTO), thus suppressing tumor growth and resistance to immunotherapy. FTO is ubiquitinated by its E3 ligase DTX2, followed by UFD1 recruitment and subsequent degradation in the proteasome. VES binds to FTO and DTX2, leading to enhanced FTO-DTX2 interaction, FTO ubiquitination, and degradation in FTO- dependent tumor cells. VES suppressed tumor growth and enhanced...
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作者：Almada, Amalia Aruda
作者单位：University of Southern California; University of Southern California
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作者：Koffas, Mattheos A. G.
作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute
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作者：Zeng, Hai Yue; Deng, Shiyu; Jin, Congcong; Shang, Zhiyun; Chang, Le; Wang, Jiajun; Han, Xue; Wang, Ao; Jin, Dan; Wang, Yubo; He, Hang; Li, Lanxin; Deng, Xing Wang; Wei, Ning
作者单位：Southwest University - China; Peking University; Peking University; Peking University; Peking University; China Agricultural University; Southwest University - China
摘要：The classical acid growth theory suggests that auxin stimulates cell expansion by triggering apoplast acidification via plasma membrane (PM)- localized H+- ATPase. Here, we reconstructed the origin and evolutionary history of auxin- mediated acid growth. Comparative phylogenomic analysis showed that most core components of acid growth originated in Charophyta and then underwent subclass expansion and functional innovation during plant terrestrialization. In Charophyceae algae Chara braunii, we...
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作者：Ramirez, Jesus Garcia; Vanhoyland, Michael; Murty, N. A. Ratan; Decramer, Thomas; Van Paesschen, Wim; Bracci, Stefania; op de Beeck, Hans; Kanwisher, Nancy; Janssen, Peter; Theys, Tom
作者单位：KU Leuven; KU Leuven; KU Leuven; University Hospital Leuven; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); KU Leuven; University of Trento; KU Leuven
摘要：Body perception plays a fundamental role in social cognition. Yet, the neural mechanisms underlying this process in humans remain elusive given the spatiotemporal constraints of functional imaging. Here, we present intracortical recordings of single- and multiunit spiking activity in two epilepsy surgery patients in or near the extrastriate body area, a critical region for body perception. Our recordings revealed a strong preference for human bodies over a large range of control stimuli. Notab...
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作者：Barzilai, Omry; Marder, Ofer; Tejero, Jose- Miguel; Ayalon, Avner; Matthews, Miryam Bar-; Abulafia, Talia; Lavi, Ron; Goder-Goldberger, Mae; Shemer, Maayan; Edeltin, Lotan; Wiegmann, Alexander; Frumkin, Amos; Karasik, Avshalom; Yasur, Gal; Yeshurun, Reuven; Zohar, Irit; Berna, Francesco; Hans, Mark; Goldberg, Jerold S.; Mcdermott, Yvonne; Spurlock, Linda; Pokhojaev, Ariel; Habashi, Waseem; May, Hila; Sarig, Rachel; Hershkovitz, Israel
作者单位：University of Haifa; Ben-Gurion University of the Negev; University of Barcelona; University of Vienna; Geological Survey Israel; Hebrew University of Jerusalem; University of Haifa; Tel Aviv University; Oranim Academic College of Education; Simon Fraser University; University of Siena; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Kent State University; Kent State University Salem; Kent State University Kent; Tel Aviv University; Tel Aviv University; Tel Aviv University
摘要：Identifying communal rituals in the Paleolithic is of scientific importance, as it reflects the expression of collective identity and the maintenance of group cohesion. This study provides evidence indicating the practice of deep cave collective rituals in the Levant during the Early Upper Paleolithic (EUP) period. It is demonstrated that these gatherings occurred within a distinct ritual compound and were centered around an engraved object in the deepest part of Manot Cave, a pivotal EUP site...
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作者：Hammer, Sebastian; Britt, Tristan L.; Kremeyer, Laurenz; Roedel, Maximilian; Cai, David; Pflaum, Jens; Siwick, Bradley J.
作者单位：McGill University; McGill University; University of Wurzburg
摘要：The formation of excited dimer states, so called excimers, is an important phenomenon in many organic molecular semiconductor solid state aggregates. In contrast to Frenkel exciton-polarons, an excimer is long-lived and energetically low-lying due to stabilization resulting from a substantial reorganization of the intermolecular geometry. Here, we show that ultrafast electron diffraction can follow the dynamics of solidstate excimer formation in polycrystalline thin films of a molecular semico...
