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作者：Sethi, Sarab S.; Bick, Avery; Chen, Ming-Yuan; Crouzeilles, Renato; Hillier, Ben V.; Lawson, Jenna; Lee, Chia-Yun; Liu, Shih-Hao; Parruco, Celso Henrique de Freitas; Rosten, Carolyn M.; Somveille, Marius; Tuanmu, Mao-Ning; Banks-Leite, Cristina
作者单位：Imperial College London; Norwegian Institute Nature Research; National Taiwan University; University of London; University College London; Academia Sinica - Taiwan
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作者：Srinivas, Pooja; Peterson, S. Brook; Gallagher, Larry A.; Wang, Yaxi; Mougous, Joseph D.
作者单位：University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Patescibacteria, also known as the Candidate Phyla Radiation, are a diverse clade of largely uncultivated, small bacteria that comprise a significant proportion of all bacterial diversity. The few members that have been cultivated exhibit a fascinating life cycle in which they grow as obligate epibionts on the surface of host bacteria. In this Perspective, we make the case that the study of these unique, divergent, and poorly characterized organisms represents an exciting frontier in microbiol...
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作者：Liu, Jiaxuan; Song, Yajie; Liu, Qingsong; Zhao, Wei; An, Hanwen; Zhou, Zinan; Xu, Zihan; Li, Menglu; Deng, Biao; Wang, Jiajun
作者单位：Harbin Institute of Technology; Harbin Institute of Technology; Harbin Institute of Technology; Harbin Institute of Technology; Chinese Academy of Sciences; Shanghai Institute of Applied Physics, CAS
摘要：The interface issue poses a limitation on the fast charging of solid- state batteries (SSBs), with the high- impedance non- Faraday electric field serving as a pivotal factor. However, the mechanism of fast- charging capability degradation triggered by the dynamic evolution of non- Faraday electric fields remains unclear due to the lack of particle- scale nondestructive detection techniques. Here, we dissect the generation and elimination processes of non- Faradaic electric field in segments u...
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作者：Mkrtchyan, Liana; Sahakyan, Harutyun; Eldstrom, Jodene; Karapetyan, Tatev; Abrahamyan, Astghik; Nazaryan, Karen; Schwarz, Juergen R.; Kneussel, Matthias; Fedida, David; Vardanyan, Vitya
作者单位：University of British Columbia; University of Hamburg; University Medical Center Hamburg-Eppendorf; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
摘要：KCNQ1 potassium channels play a pivotal role in the physiology and pathophysiology of several human excitable and epithelial tissues. The latest cryo- electron microscopy (cryo- EM) structures provide unique insights into channel function and pharmacology, opening avenues for different therapeutic strategies against human diseases associated with KCNQ1 mutations. However, these structures also raise fundamental questions about the mechanisms of ion permeation. Cryo- EM structures thought to re...
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作者：Shi, Tuo; Kim, Yeeun; Llamas, Juan; Wang, Xizi; Fabian, Peter; Lozito, Thomas P.; Segil, Neil; Gnedeva, Ksenia; Crump, J. Gage
作者单位：University of Southern California; University of Southern California
摘要：During tissue regeneration, lineage- related cells can switch their fate to replace missing cells. This cell plasticity is particularly prominent in more regenerative vertebrates such as zebrafish, yet the molecular basis by which cells transdifferentiate into another cell type upon injury remains unclear. Here, we investigate the epigenetic basis of regenerative transdifferentiation in the inner ear, where supporting cells (SCs) generate mechanosensory hair cells (HCs) upon damage. By compari...
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作者：Chai, Zuying; Silverman, Daniel; Li, Sihan; Bina, Parinaz; Yau, King - Wai
作者单位：Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Icahn School of Medicine at Mount Sinai; University of California System; University of California San Diego; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
摘要：Retinal rods and cones underlie scotopic and photopic vision, respectively. Their pigments exhibit spontaneous isomerizations (quantal noise) in darkness due to intrinsic thermal energy. This quantal noise, albeit exceedingly low in rods, dictates the light threshold for scotopic vision. The same quantal noise in cones, however, is too low to explain the much higher diurnal light threshold. Separately, a dark continuous noise is present in rods, long accepted to originate from an intrinsic ran...
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作者：Mughal, Amreen; Hennig, Grant W.; Heppner, Thomas; Tsoukias, Nikolaos M.; Hill-Eubanks, David; Nelson, Mark T.
作者单位：University of Vermont; State University System of Florida; Florida International University; University of Manchester; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); NIH National Institute of Neurological Disorders & Stroke (NINDS)
摘要：The routing of blood flow throughout the brain vasculature is precisely controlled by mechanisms that serve to maintain a fine balance between local neuronal demands and vascular supply of nutrients. We recently identified two capillary endothelial cell (cEC)-based mechanisms that control cerebral blood flow in vivo: 1) electrical signaling, mediated by extracellular K+- dependent activation of strong inward rectifying K+ (Kir2.1) channels, which are steeply activated by hyperpolarization and ...
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作者：Yu, Huijing; Xiao, Guanli; Gu, Mingyao; Zhang, Liting; Xia, Ming; Mo, Shimin; Zhao, Yuying; Wei, Chaoliang
作者单位：Shenzhen University; Shenzhen University; Shenzhen Longhua District Central Hospital; Guangzhou Medical University
摘要：Increasing evidence suggests that tumor cells exhibit extreme plasticity in migration modes in order to adapt to microenvironments. However, the underlying mechanism for governing the migration mode switching is still unclear. Here, we revealed that epithelial tumor cells could develop a stable directional mode driven by hyperactivated ERK activity. This highly activated and dynamically changing ERK activity, called pERK transition, is crucial for inducing the switch from pauses state to direc...
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作者：Brown, Timothy M.; O'Connor, Joseph; Genner, Martin J.
作者单位：University of Bristol; University of Leeds
摘要：Climate change has emerged as a key threat to biodiversity, leading to broad- scale shifts in distributions of marine and terrestrial species as they attempt to track thermally suitable habitat. By contrast, our understanding of climate responses of freshwater species is relatively undeveloped, limiting our knowledge of whether projected warming will lead to freshwater biodiversity loss. Here, we linked a multicontinental database of riverine fish population abundance time series collected fro...
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作者：Liu, Chong; Ge, Robbie; Chen, Jun; Guo, Hongmei; Bartholome, Tyler A.; Maiti, Debabrata; Ge, Haibo
作者单位：Texas Tech University System; Texas Tech University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay
摘要：Exploration of novel chiral pharmaceutical candidates is motivation to immersive efforts among synthetic chemists. Achieving skeletal construction and chiral diversity in a highly efficient manner is a momentous goal in the chemical society. Unfortunately, current methods for chiral induction focus primarily on a specific site. Herein, we realized the asymmetric chain- walking arylation of alkenyl alcohols for the construction of multisite tertiary and quaternary stereocenters in high yields a...
