-
作者：Pisegna, Giulia; Saha, Suropriya; Golestanian, Ramin
作者单位：Max Planck Society; University of Oxford
摘要：Phenomenological rules that govern the collective behavior of complex physical systems are powerful tools because they can make concrete predictions about their universality class based on generic considerations, such as symmetries, conservation laws, and dimensionality. While in most cases such considerations are manifestly ingrained in the constituents, novel phenomenology can emerge when composite units associated with emergent symmetries dominate the behavior of the system. We study a gene...
-
作者：Yang, Zhenghai; Medvedkov, Iakov A.; Goettl, Shane J.; Nikolayev, Anatoliy A.; Mebel, Alexander M.; Li, Xiaohu; Kaiser, Ralf I.
作者单位：University of Hawaii System; University of Hawaii Manoa; Samara National Research University; State University System of Florida; Florida International University; Chinese Academy of Sciences; Xinjiang Astronomy Observatory, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences
摘要：The cyclopentadiene (C5H6) molecule has emerged as a molecular building block of nonplanar polycyclic aromatic hydrocarbons (PAHs) and carbonaceous nanostructures such as corannulene (C20H10), nanobowls (C40H10), and fullerenes (C60) in deep space. However, the underlying elementary gas- phase processes synthesizing cyclopentadiene from acyclic hydrocarbon precursors have remained elusive. Here, by merging crossed molecular beam experiments with rate coefficient calculations and comprehensive ...
-
作者：Ling, Xiaoyu; Guo, Huijuan; Di, Jian; Xie, Liqiang; Zhu-Salzman, Keyan; Ge, Feng; Zhao, Zihua; Sun, Yucheng
作者单位：Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Texas A&M University System; Texas A&M University College Station; Shandong Academy of Agricultural Sciences; China Agricultural University
摘要：DNA repair systems are essential to maintain genome integrity and stability.Some obligate endosymbionts that experience long- term symbiosis with the insect hosts, however, have lost their key components for DNA repair. It is largely unexplored how the bacterial endosymbionts cope with the increased demand for mismatch repairs under heat stresses. Here, we showed that ibpA, a small heat shock protein encoded by Buchnera aphidicola, directly interacted with the cytoskeletal actin to prevent its...
-
作者：de Araujo, Carlos B.
作者单位：Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
-
作者：Isay, Sophie E.; Vornholz, Larsen; Schnalzger, Theresa; Groll, Tanja; Magg, Thomas; Loll, Patricia; Weirich, Gregor; Steiger, Katja; Hauck, Fabian; Ruland, Juergen
作者单位：Technical University of Munich; Technical University of Munich; Technical University of Munich; University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); Technical University of Munich; German Center for Infection Research
摘要：Hemophagocytic lymphohistiocytosis (HLH) is a life- threatening syndrome fueled by uncontrolled mononuclear phagocyte activity, yet the innate immune mechanisms driving HLH pathogenesis remain elusive. Germline gain- of- function (GOF) mutations in CARD11, a pivotal regulator of lymphocyte antigen receptor signaling, cause the is frequently associated with HLH development. Given that CARD11 is physiologically expressed not only in lymphocytes but also in dendritic cells (DCs), we explored whet...
-
作者：Liu, Yihan; Putcha, Arjun; Lyda, Gavin; Peng, Nanqi; Pai, Salil; Nguyen, Tien; Xing, Sicheng; Peng, Shang; Fan, Yiyang; Wu, Yizhang; Xie, Wanrong; Bai, Wubin
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：Neuromuscular diseases pose significant health and economic challenges, necessitating innovative monitoring technologies for personalizable treatment. Existing devices detect muscular motions either indirectly from mechanoacoustic signatures on skin surface or via ultrasound waves that demand specialized skin adhesion. Here, we report a wireless wearable system, Laryngeal Health Monitor (LaHMo), designed to be conformally placed on the neck for continuously measuring movements of underlying mu...
-
作者：Liu, Li; Zhang, Jianping; Li, Jingbo; He, Yahui; Gao, Zhongzhe; Jiang, Leping
作者单位：Stanford University; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Stanford University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The origins of rice domestication and the beginnings of alcoholic fermentation in China are intriguing research topics, with the Shangshan culture in the Lower Yangzi River region being a focal point of archaeological investigations. This study employs a multi- proxy approach (phytolith, starch, and fungi) to analyze microfossil remains associated with pottery vessels from the earliest phase of the Shangshan site (ca. 10,000 to 9,000 cal. BP). The results indicate that rice was consumed as a d...
-
作者：Liang, Zhancong; Zhou, Liyuan; Chang, Yuqing; Qin, Yiming; Chan, Chak K.
作者单位：King Abdullah University of Science & Technology; City University of Hong Kong
摘要：Biomass- burning organic aerosol(s) (BBOA) are rich in brown carbon, which significantly absorbs solar irradiation and potentially accelerates global warming. Despite its importance, the multiphase photochemistry of BBOA after light absorption remains poorly understood due to challenges in determining the oxidant concentrations and the reaction kinetics within aerosol particles. In this study, we explored the photochemical reactivity of BBOA particles in multiphase S(IV) oxidation to sulfate. ...
-
作者：Dai, Lei; Wu, Zuowei; Sahin, Orhan; Zhao, Shaohua; Yu, Edward W.; Zhang, Qijing
作者单位：Iowa State University; Iowa State University; US Food & Drug Administration (FDA); University System of Ohio; Case Western Reserve University
摘要：The resistance- nodulation-cell division (RND) superfamily of multidrug efflux systems are important players in mediating antibiotic resistance in gram- negative pathogens. Campylobacter jejuni, a major enteric pathogen, utilizes an RND-type transporter system, CmeABC, as the primary mechanism for extrusion of various antibiotics. Recently, a functionally potent variant of CmeABC (named RE- CmeABC) emerged in clinical Campylobacter isolates, conferring enhanced resistance to multiple antibioti...
-
作者：Jo, Wendy K.; Cassiano, Murilo Henrique Anzolini; de Oliveira-Filho, Edmilson Ferreira; Bruenink, Sebastian; Yansanjav, Adiya; Yihune, Mesele; Koshkina, Alyona I.; Lukashev, Alexander N.; Lavrenchenko, Leonid A.; Lebedev, Vladimir S.; Olayemi, Ayodeji; Bangura, Umaru; Salas- Rojask, Monica; Aguilar-Setienk, Alvaro; Fichet- Calvetj, Elisabeth; Drexlera, Jan Felix
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Mongolian Academy of Sciences; Addis Ababa University; Association for the Conservation of Biodiversity of Kazakhstan; Sechenov First Moscow State Medical University; Russian Academy of Sciences; Saratov Scientific Center of the Russian Academy of Sciences; Severtsov Institute of Ecology & Evolution; Lomonosov Moscow State University; Obafemi Awolowo University; Njala University; Leibniz Association; Bernhard Nocht Institut fur Tropenmedizin
摘要：Hepatitis E virus (HEY; family Hepeviridae) infections cause >40,000 human deaths annually. Zoonotic infections predominantly originate from ungulates and occasionally from rats, highlighting the zoonotic potential of rodent- associated hepeviruses. We conducted host genomic data mining and uncovered two genetically divergent rodent- associated hepeviruses, and two bat- associated hepeviruses genetically related to known bat- associated strains. We thus analyzed 2,565 liver specimens from 108 ...
