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作者：Riso, Mariapia; Shah, Rohan N.; Koide, Akiko; Ruthenburg, Alexander J.; Koide, Shohei; Hattori, Takamitsu
作者单位：NYU Langone Medical Center; University of Chicago; University of Chicago; New York University; University of Chicago
摘要：Posttranslational modifications (PTMs) of proteins play critical roles in regulating many cellular events. Antibodies targeting site- specific PTMs are essential tools for detecting and enriching PTMs at sites of interest. However, fundamental difficulties in molecular recognition of both PTM and surrounding peptide sequence have hindered the efficient generation of highly sequence- specific anti-PTM antibodies. Furthermore, the widespread use of potentially inconsistent, nonrenewable, and mol...
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作者：Shaw, Sebastian; Cohn, Ian S.; Baptista, Rodrigo P.; Xia, Guoqin; Melillo, Bruno; Agyabeng-Dadzie, Fiifi; Kissinger, Jessica C.; Striepen, Boris
作者单位：University of Pennsylvania; Houston Methodist; Scripps Research Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia
摘要：Parasites and their hosts are engaged in reciprocal coevolution that balances competing mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but genomic reassortment between different strains can enable parasites to jump host barriers and conquer new niches. In the apicomplexan parasite Cryptosporidium, genetic exchange has been hypothesized to play a prominent role in adaptation to humans. The sexual lifecycle of the parasite provides a potential mechanism f...
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作者：Li, Yunzhou; Sun, Ming; Yang, Xiangyan; Yang, Molin; Kleisner, Kristin M.; Mills, Katherine E.; Tang, Yi; Du, Feiyan; Qiu, Yongsong; Ren, Yiping; Chen, Yong
作者单位：State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Environmental Defense Fund; Gulf of Maine Research Institute; Shanghai Ocean University; Chinese Academy of Fishery Sciences; South China Sea Fisheries Research Institute, CAFS; Ocean University of China
摘要：Climate change is a new disrupter to global fisheries systems and their governance frameworks. It poses a pressing management challenge, particularly in China, which is renowned as the world's largest fishing country and seafood producer. As climate change continues to intensify in the region and climate awareness grows within the country's national policy, the need to understand China's fisheries' resilience to the escalating climate crisis becomes paramount. In this study, we conduct an inte...
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作者：Saulsbury, James G.; Parins-Fukuchi, C. Tomomi; Wilson, Connor J.; Reitan, Trond; Liow, Lee Hsiang
作者单位：University of Oslo; University of Kansas; University of Toronto; University of Oxford; University of Arizona; University of Oslo
摘要：Red Queen (RQ) theory states that adaptation does not protect species from extinction because their competitors are continually adapting alongside them. RQ was founded on the apparent independence of extinction risk and fossil taxon age, but analytical developments have since demonstrated that age- dependent extinction is widespread, usually most intense among young species. Here, we develop ecological neutral theory as a general framework for modeling fossil species survivorship under incompl...
