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• The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells AI翻译
  作者：Zheng, Miaomiao; Wang, Shuo; Tang, Kexin; Kong, Ruixue; Wang, Xuemeng; Zhou, Jun; Chen, Yan; Wang, Yijie
  作者单位：Shandong Normal University
  摘要：Poly(ADP- ribose) polymerase 1 (PARP1) plays a crucial role in DNA repair and genomic stability maintenance. However, the regulatory mechanisms governing PARP1 activity, particularly through deubiquitination, remain poorly elucidated. Using a deubiquitinase (DUB) library binding screen, we identified cylindromatosis (CYLD) as a bona fide DUB for PARP1 in breast cancer cells. Mechanistically, CYLD is recruited by PARP1 to DNA lesions upon genotoxic stress, where it cleaves K63- linked polyubiqu...
• GPCR targeting of E3 ubiquitin ligase MDM2 by inactive β- arrestin (vol 120 , e2301934120, 2023) AI翻译
  作者：Yun, Yaejin; Yoon, Hye - Jin; Jeong, Yejin; Choi, Yuri; Jang, Soonmin; Chung, Ka Young; Lee, Hyung Ho
• Development of broad modulus profile upon polymer-polymer interface formation between immiscible glassy-rubbery domains AI翻译
  作者：Gagnon, Yannic J.; Burton, Justin C.; Roth, Connie B.
  作者单位：Emory University
  摘要：Interfaces of glassy materials such as thin films, blends, and composites create strong unidirectional gradients to the local heterogeneous dynamics that can be used to elucidate the length scales and mechanisms associated with the dynamic heterogeneity of glasses. We focus on bilayer films of two different polymers with very different glass transition temperatures (T-g) where previous work has demonstrated a long-range (similar to 200 nm) profile in local T-g(z) is established between immisci...
• Genetic differentiation and precolonial Indigenous cultivation of hazelnut (Corylus cornuta, Betulaceae) in western North America (vol 121, e2402304121, 2024) AI翻译
  作者：Armstrong, Chelsey Geralda; Clemente-Carvalho, Rute B. G.; Turner, Nancy J.; Wickham, Sara; Trant, Andrew; Lemay, Matthew A.
• Identification of highly selective SIK 1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation AI翻译
  作者：Babbe, Holger; Sundberg, Thomas B.; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T.; Mak, Puiying A.; Mathur, Ashok; Mercado-Marin, Eduardo, V; Metkar, Shailesh; Raymond, Donald D.; Rives, Marie -Laure; Rizzolio, Michele; Shaffer, Paul L.; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P.; Wei, Jianmei; Desai, Prerak T.; Ong, Luvena L.; Koudriakova, Tatiana; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar K.; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B.; Plevy, Scott; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.
  作者单位：Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：The salt- inducible kinases (SIK) 1-3 are key regulators of pro- versus anti- inflammatory cytokine responses during innate immune activation. The lack of highly SIK- family or SIK isoform- selective inhibitors suitable for repeat, oral dosing has limited the study of the optimal SIK isoform selectivity profile for suppressing inflammation in vivo. To overcome this challenge, we devised a structure-based design strategy for developing potent SIK inhibitors that are highly selective against oth...
• How cognitive selection affects language change AI翻译
  作者：Li, Ying; Breithaupt, Fritz; Hills, Thomas; Lin, Ziyong; Chen, Yanyan; Siew, Cynthia S. W.; Hertwig, Ralph
  作者单位：Chinese Academy of Sciences; Institute of Psychology, CAS; Max Planck Society; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Warwick; Max Planck Society; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National University of Singapore
  摘要：Like biological species, words in language must compete to survive. Previously, it has been shown that language changes in response to cognitive constraints and over time becomes more learnable. Here, we use two complementary research paradigms to demonstrate how the survival of existing word forms can be predicted by psycholinguistic properties that impact language production. In the first study, we analyzed the survival of words in the context of interpersonal communication. We analyzed data...
• Thermal suppression of charge disproportionation accelerates interface electron transfer of water electrolysis AI翻译
  作者：Lu, Mengfei; Du, Yu; Yan, Shicheng; Yu, Tao; Zou, Zhigang
  作者单位：Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Nanjing University
  摘要：The sluggish electron transfer kinetics in electrode polarization driven oxygen evolution reaction (OER) result in big energy barriers of water electrolysis. Accelerating the electron transfer at the electrolyte/catalytic layer/catalyst bulk interfaces is an efficient way to improve electricityto- hydrogenefficiency. Herein, the electron transfer at the Sr3Fe2O7@ SrFeOOH bulk/catalytic layer interface is accelerated by heating to eliminate charge disproportionation from Fe4+ to Fe3+ and Fe5+ i...
• Nonlinear bias toward complex contagion in uncertain transmission settings AI翻译
  作者：St-Onge, Guillaume; Hebert-Dufresne, Laurent; Allard, Antoine
  作者单位：Northeastern University; University of Vermont; University of Vermont; Laval University; Laval University
  摘要：Current epidemics in the biological and social domains are challenging the standard assumptions of mathematical contagion models. Chief among them are the complex patterns of transmission caused by heterogeneous group sizes and infection risk varying by orders of magnitude in different settings, like indoor versus outdoor gatherings in the COVID-19 pandemic or different moderation practices in social media communities. However, quantifying these heterogeneous levels of risk is difficult, and m...
• Reply to Zhang et al.: Parallel vector memories are required to explain all behavioral data in navigating bumblebees AI翻译
  作者：Patel, Rickesh N.; Roberts, Natalie S.; Kempenaers, Julian; Zadel, Ana; Heinze, Stanley
  作者单位：Lund University; Lund University
• A model for collagen secretion by intercompartmental continuities AI翻译
  作者：Bunel, Louis; Pincet, Lancelot; Malhotra, Vivek; Raote, Ishier; Pincet, Frederic
  作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; ICREA; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS)
  摘要：Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII- coated vesicle of 60 nm average diameter. We have previously suggested that procollagen is transported from the ER to the next secretory organelle, the ER-Golgi intermediate compartment (ERGIC), in TANGO1- dependent interorganelle tunnels. In the theoretical model presented here, w...