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作者：Lee, Taeyong; Seong, Min Ji; Ahn, Hyo Chul; Baek, Minsung; Park, Kiho; Oh, Jihoon; Choi, Taehoon; Choi, Jang Wook
作者单位：Seoul National University (SNU); Seoul National University (SNU)
摘要：Silicon (Si) anodes have long been recognized to significantly improve the energy density and fast- charging capability of lithium- ion batteries (LIBs). However, the implementation of these anodes in commercial LIB cells has progressed incrementally due to the immense volume change of Si across its full state- of- charge (SOC) range. Here, we report an anode- tailored full- cell design (ATFD), which incorporates micrometer- sized silicon (mu- Si) alone, for operation over a limited, prespecif...
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作者：Chhabra, Gagan; Ahmad, Nihal
作者单位：University of Wisconsin System; University of Wisconsin Madison
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作者：D'Alessandro, Angelo; Earley, Eric J.; Nemkov, Travis; Stephenson, Daniel; Dzieciatkowska, Monika; Hansen, Kirk C.; Minetti, Giampaolo; Champigneulle, Benoit; Stauffer, Emeric; Pichon, Aurelien; Furian, Michael; Verges, Samuel; Kleinman, Steven; Norris, Philip J.; Busch, Michael P.; Page, Grier P.; Kaestner, Lars
作者单位：University of Colorado System; University of Colorado Anschutz Medical Campus; Research Triangle Institute; University of Pavia; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite de Poitiers; University of Zurich; University of British Columbia; Vitalant; Vitalant Research Institute; Saarland University
摘要：Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes to physiological human adaptations to hypoxia, a multifaceted process critical to health and disease. To delve into the molecular underpinnings of this phenomenon, first, we performed a multi- omics analysis of RBCs from six lowlanders after exposure to high- altitude hypoxia, with longitudinal sampling at baseline, upon ascent to 5,100 m and descent to sea level. Results highlighted an association between ...
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作者：Verzhbinsky, Ilya A.; Rubin, Daniel B.; Kajfez, Sophie; Bu, Yiting; Kelemen, Jessica N.; Kapitonava, Anastasia; Williams, Ziv M.; Hochberg, Leigh R.; Cash, Sydney S.; Halgren, Eric
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California San Diego; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brown University; Brown University
摘要：How the human cortex integrates (binds) information encoded by spatially distributed neurons remains largely unknown. One hypothesis suggests that synchronous bursts of high- frequency oscillations (ripples) contribute to binding by facilitating integration of neuronal firing across different cortical locations. While studies have demonstrated that ripples modulate local activity in the cortex, it is not known whether their co- occurrence coordinates neural firing across larger distances. We t...
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作者：Bergstrom, Carl T.; Hanage, William P.
作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard T.H. Chan School of Public Health
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作者：Borenas, Marcus; Umapathy, Ganesh; Lind, Dan E.; Lai, Wei -Yun; Guan, Jikui; Johansson, Joel; Jennische, Eva; Schmidt, Alexander; Kurhe, Yeshwant; Gabre, Jonatan L.; Aniszewska, Agata; Stromberg, Anneli; Bemark, Mats; Hall, Michael N.; Van den Eynden, Jimmy; Hallberg, Bengt; Palmer, Ruth H.
作者单位：University of Gothenburg; Ghent University; University of Gothenburg; Sahlgrenska University Hospital; University of Basel
摘要：High -risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high -risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3- related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically modified mouse NB models. Here, we identify an underlying molecular mechanism, in which ALK si...
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作者：Wu, Cheng- Guo; Balakrishnan, Vijaya K.; Merrill, Ronald A.; Parihar, Pankaj S.; Konovolov, Kirill; Chen, Yu- Chia; Xu, Zhen; Wei, Hui; Sundaresan, Ramya; Cui, Qiang; Wadzinski, Brian E.; Swingle, Mark R.; Musiyenko, Alla; Chung, Wendy K.; Honkanen, Richard E.; Suzuki, Aussie; Huang, Xuhui; Strack, Stefan; Xing, Yongna
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Iowa; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Iowa; Boston University; Vanderbilt University; University of South Alabama; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：Intrinsically disordered regions (IDR) and short linear motifs (SLiMs) play pivotal roles in the intricate signaling networks governed by phosphatases and kinases. B568 (encoded by PPP2R5D) is a regulatory subunit of protein phosphatase 2A (PP2A) with long IDRs that harbor a substrate- mimicking SLiM and multiple phosphorylation sites. De novo missense mutations in PPP2R5D cause intellectual disabilities (ID), macrocephaly, Parkinsonism, and a broad range of neurological symptoms. Our single- ...
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作者：Chen, Yuzhou; Gel, Yulia R.; Marathe, Madhav, V; Poor, H. Vincent
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Texas System; University of Texas Dallas; National Science Foundation (NSF); NSF - Directorate for Mathematical & Physical Sciences (MPS); NSF - Division of Mathematical Sciences (DMS); University of Virginia; University of Virginia; Princeton University
摘要：Networks allow us to describe a wide range of interaction phenomena that occur in complex systems arising in such diverse fields of knowledge as neuroscience, engineering, ecology, finance, and social sciences. Until very recently, the primary focus of network models and tools has been on describing the pairwise relationships between system entities. However, increasingly more studies indicate that polyadic or higher-order group relationships among multiple network entities may be the key towa...
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作者：Hu, Hongling; Luo, Sheng; Lai, Pinglin; Lai, Mingqiang; Mao, Linlin; Zhang, Sheng; Jiang, Yuanjun; Wen, Jiaxin; Zhou, Wu; Liu, Xiaolin; Wang, Liang; Huang, Minjun; Hu, Yanjun; Zhao, Xiaoyang; Xia, Laixin; Zhou, Weijie; Jiang, Yu; Zou, Zhipeng; Liu, Anling; Guo, Bin; Bai, Xiaochun
作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Southern Medical University - China
摘要：Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR [db/db (diabetes)] and leptin [ob/ob (obese)] are not identical, and the cause remains unclear. Here, we show that db/db, but not ob/ob, mice had defect in tenotomy- induced heterotopic ossification (HO), implicating alternative ligand(s) for LepR might be involved. Ligand screening revealed that ANGPTL4 (angiopoietin-like protein 4), a stress and fasting- induced factor, was eli...
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作者：Zhang, Fengxiang; Pu, Yi; Kong, Xiang-Zhen
作者单位：Zhejiang University; Zhejiang University; East China Normal University
