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最新文章

• Confined cell migration along extracellular matrix space in vivo AI翻译
  作者：Chepizhko, Oleksandr; Armengol-Collado, Josep-Maria; Alexander, Stephanie; Wagena, Esther; Weigelin, Bettina; Giomi, Luca; Friedi, Peter; Zapperi, Stefano; La Porta, Caterina A. M.
  作者单位：Leiden University; Leiden University - Excl LUMC; University of Texas System; UTMD Anderson Cancer Center; University of Wurzburg; University of Wurzburg; Radboud University Nijmegen; University of Milan; Consiglio Nazionale delle Ricerche (CNR); Istituto di Chimica della Materia Condensata e di Tecnologie per l Energia (ICMATE-CNR); University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Eberhard Karls University of Tubingen
  摘要：Collective migration of cancer cells is often interpreted using concepts derived from the physics of active matter, but the experimental evidence is mostly restricted to observations made in vitro. Here, we study collective invasion of metastatic cancer cells injected into the mouse deep dermis using intravital multiphoton microscopy combined with a skin window technique and three-dimensional quantitative image analysis. We observe a multicellular but low-cohesive migration mode characterized ...
• Structural and functional dynamics of human cone cGMP- phosphodiesterase important for photopic vision AI翻译
  作者：Singh, Sneha; Srivastava, Dhiraj; Boyd, Kimberly; Artemyev, Nikolai O.
  作者单位：University of Iowa; University of Iowa
  摘要：Cone cGMP- phosphodiesterase (PDE6) is the key effector enzyme for daylight vision, and its properties are critical for shaping distinct physiology of cone photoreceptors. We determined the structures of human cone PDE6C in various liganded states by single- particle cryo-EM that reveal essential functional dynamics and adaptations of the enzyme. Our analysis exposed the dynamic nature of PDE6C association with its regulatory gamma- subunit (P gamma) which allows openings of the catalytic pock...
• Profile of Thomas W. McDade AI翻译
  作者：Langlois, Jill
• Hierarchical behavior control by a single class of interneurons ( vol 121 , e2410789121 , 2024) AI翻译
  作者：Huo, Jing; Xu, Tianqi; Liu, Qi; Polat, Mahiber; Kumar, Sandeep; Zhang, Xiaoqian; Leifer, Andrew M.; Wen, Quan
• Social anxiety disorder- associated gut microbiota increases social fear ( vol 121 , e2308706120 ,2023) AI翻译
  作者：Ritz, Nathaniel L.; Brocka, Marta; Butler, Mary I.; Cowan, Caitlin S. M.; Turkington, Christopher J. R.; Draper, Lorraine A.; Bastiaanssen, Thomaz F. S.; Turpin, Valentine; Morales, Lorena; Campos, David; Gheorghe, Cassandra E.; Ratsika, Anna; Sharma, Virat; Golubeva, Anna V.; Aburto, Maria R.; Shkoporov, Andrey N.; Hill, Gerard M. Moloney Colin; Clarke, Gerard; Slattery, David A.; Dinan, Timothy G.; Cryan, John F.
• Gaze into social bonds: Unlocking great ape emotions through eye- tracking AI翻译
  作者：Kret, Mariska E.
  作者单位：Leiden University - Excl LUMC; Leiden University
• Genome- wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells AI翻译
  作者：Matta, Sumit K.; Kohio, Hinissan P.; Chandra, Pallavi; Brown, Adam; Doench, John G.; Philips, Jennifer A.; Ding, Siyuan; Sibley, L. David
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：To define cellular immunity to the intracellular pathogen Toxoplasma gondii, we performed a genome- wide CRISPR loss- of- function screen to identify genes important for (interferon gamma) IFN-gamma -dependent growth restriction. We revealed a role for the tumor suppressor NF2/Merlin for maximum induction of Interferon Stimulated Genes (ISG), which are positively regulated by the transcription factor IRF- 1. We then performed an ISG- targeted CRISPR screen that identified the host E3 ubiquitin...
• A species' response to spatial climatic variation does not predict its response to climate change AI翻译
  作者：Perret, Daniel L.; Evans, Margaret E. K.; Sax, Dov F.
  作者单位：Brown University; University of Arizona; Brown University; United States Department of Agriculture (USDA); United States Forest Service; Oak Ridge Associated Universities; United States Department of Energy (DOE); Oak Ridge Institute for Science & Education
  摘要：The dominant paradigm for assessing ecological responses to climate change assumes that future states of individuals and populations can be predicted by current, species -wide performance variation across spatial climatic gradients. However, if the fates of ecological systems are better predicted by past responses to in situ climatic variation through time, this current analytical paradigm may be severely misleading. Empirically testing whether spatial or temporal climate responses better pred...
• Integrin- activating Yersinia protein Invasin sustains long- term expansion of primary epithelial cells as 2D organoid sheets AI翻译
  作者：Wijnakker, Joost J. A. P. M.; Son, Gijs J. F. van; Krueger, Daniel; Wetering, Willine J. van de; Iglesias, Carmen Lopez -; Schreurs, Robin; van Rijt, Fenna; Lim, Sangho; Lin, Lin; Peters, Peter J.; Isberg, Ralph R.; Janda, Claudia Y.; de Lau, Wim; Clevers, Hans
  作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; Princess Maxima Center; Maastricht University; Tufts University; Roche Holding
  摘要：Matrigel (R)/BME (R), a basement membrane- like preparation, supports long- term growth of epithelial 3D organoids from adult stem cells [T. Sato et al., Nature 459, 262-265 (2009); T. Sato et al., Gastroenterology 141, 1762-1772 (2011)]. Here, we show that interaction between Matrigel's major component laminin-111 with epithelial alpha 6 beta 1- integrin is crucial for this process. The outer membrane protein Invasin of Yersinia is known to activate multiple integrin-beta 1 complexes, includi...
• De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries (vol 119, e2210435119, 2022) AI翻译
  作者：Wahl, Sebastian C. T.; Travaline, Tara L.; Ramirez, Jessica D.; Choudary, Santosh K.; Agarwal, Sorabh; Walkup, Ward G.; Olsen, Tivoli J.; Brennan, Matthew J.; Verdine, Gregory L.