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最新文章

• Profile of Stefan W. Hell AI翻译
  作者：Ravindran, Sandeep
• Lysophagy protects against propagation of α- synuclein aggregation through ruptured lysosomal vesicles AI翻译
  作者：Kakuda, Keita; Ikenaka, Kensuke; Kuma, Akiko; Doi, Junko; Aguirre, Cesar; Wang, Nan; Ajiki, Takahiro; Choong, Chi- Jing; Kimura, Yasuyoshi; Badawy, Shaymaa Mohamed Mohamed; Shima, Takayuki; Nakamura, Shuhei; Baba, Kousuke; Nagano, Seiichi; Nagai, Yoshitaka; Yoshimori, Tamotsu; Mochizuki, Hideki
  作者单位：University of Osaka; University of Osaka; Egyptian Knowledge Bank (EKB); Zagazig University; Nara Medical University; University of Osaka
  摘要：The neuron - to- neuronpropagation of misfolded alpha-synuclein (alpha Syn) aggregates is thought to be key to the pathogenesis of synucleinopathies. Recent studies have shown that extracellular alpha Syn aggregates taken up by the endosomal-lysosomal system can rupture the lysosomal vesicular membrane; however, it remains unclear whether lysosomal rupture leads to the transmission of alpha Syn aggregation. Here, we applied cell -based alpha Syn propagation models to show that ruptured lysosom...
• In situ architecture of a nucleoid- associated biomolecular co- condensate that regulates bacterial cell division AI翻译
  作者：Xu, Peng; Schumacher, Dominik; Liu, Chuan; Harms, Andrea; Dickmanns, Marcel; Beck, Florian; Plitzko, Juergen M.; Baumeister, Wolfgang; Sogaard-Andersen, Lotte
  作者单位：Max Planck Society; Max Planck Society; Max Planck Society
  摘要：In most bacteria, cell division depends on the tubulin- homolog FtsZ that polymerizes in a GTP- dependent manner to form the cytokinetic Z- ring at the future division site. Subsequently, the Z- ring recruits, directly or indirectly, all other proteins of the divisome complex that executes cytokinesis. A critical step in this process is the precise positioning of the Z- ring at the future division site. While the divisome proteins are generally conserved, the regulatory systems that position t...
• How and why funders support engaged research AI翻译
  作者：Bednarek, Angela T.; Miyamoto, Ben; Corbett, Kristin; Hudson, Charlotte; Scarrow, Gayle; Brass, Maeghan; Dumont, Kim; Holmes, Bev; Supplee, Lauren; Mclean, Robert; Bhatia, Jaspal; Chappell, Shamira; Velez, Maggie Gorman; Kolavalli, Chhaya
  作者单位：National Oceanic Atmospheric Admin (NOAA) - USA; University of Michigan System; University of Michigan; American Institutes for Research
  摘要：Research that better aligns policy, practice, and research communities is gaining momentum around the world. This includes engaged research strategies that bring partners, and their diverse perspectives and kinds of knowledge, together to shape research agendas with on- the- ground- needs and to create dynamic problem- solving processes. These approaches aim to generate more equitable and effective solutions to societal challenges. Although many of these partnered strategies have a longstandin...
• Cytochrome c oxidase deficiency detection in human fibroblasts using scanning electrochemical microscopy AI翻译
  作者：Thind, Shubhneet; Lima, Dhesmon; Booy, Evan; Trinh, Dao; McKenna, Sean A.; Kuss, Sabine
  作者单位：University of Manitoba; University of Manitoba; La Rochelle Universite; Centre National de la Recherche Scientifique (CNRS)
  摘要：Cytochrome c oxidase deficiency (COXD) is an inherited disorder characterized by the absence or mutation in the genes encoding for the cytochrome c oxidase protein (COX). COX deficiency results in severe muscle weakness, heart, liver, and kidney disorders, as well as brain damage in infants and adolescents, leading to death in many cases. With no cure for this disorder, finding an efficient, inexpensive, and early means of diagnosis is essential to minimize symptoms and long -term disabilities...
• Designing the stripe-ordered cuprate phase diagram through uniaxial-stress AI翻译
  作者：Guguchia, Z.; Das, D.; Simutis, G.; Adachi, T.; Kuespert, J.; Kitajima, N.; Elender, M.; Grinenko, V.; Ivashko, O.; Von Zimmermann, M.; Muellerh, M.; Mielke III, C.; Hotz, F.; Mudry, C.; Baines, C.; Bartkowiak, M.; Shiroka, T.; Koike, Y.; Amato, A.; Hicks, C. W.; Gu, G. D.; Tranquada, J. M.; Klauss, H-H; Chang, J. J.; Janoschek, M.; Luetkens, H.
  作者单位：Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Sophia University; University of Zurich; Tohoku University; Shanghai Jiao Tong University; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; University of Birmingham; United States Department of Energy (DOE); Brookhaven National Laboratory; Technische Universitat Dresden
  摘要：The ability to efficiently control charge and spin in the cuprate high-temperature superconductors is crucial for fundamental research and underpins technological development. Here, we explore the tunability of magnetism, superconductivity, and crystal structure in the stripe phase of the cuprate La2-xBaxCuO4, with x = 0.115 and 0.135, by employing temperature-dependent (down to 400 mK) muon-spin rotation and AC susceptibility, as well as X-ray scattering experiments under compressive uniaxial...
• Forest mosaics, not savanna corridors, dominated in Southeast Asia during the Last Glacial Maximum AI翻译
  作者：Hamilton, Rebecca; Amano, Noel; Bradshaw, Corey J. A.; Saltre, Frederik; Patalano, Robert; Penny, Dan; Stevenson, Janelle; Wolfhagen, Jesse; Roberts, Patrick
  作者单位：Max Planck Society; Max Planck Society; University of Sydney; Flinders University South Australia; Bryant University; Australian National University; Purdue University System; Purdue University; University of the Philippines System; University of the Philippines Diliman
  摘要：The dominant paradigm is that large tracts of Southeast Asia's lowland rainforests were replaced with a savanna corridor during the cooler, more seasonal climates of the Last Glacial Maximum (LGM) (23,000 to 19,000 y ago). This interpretation has implications for understanding the resilience of Asia's tropical forests to projected climate change, implying a vulnerability to savannization. A savanna corridor is also an important foundation for archaeological interpretations of how humans moved ...
• Disadvantaged group members are prouder of their group when using the language of the dominant group compared to their native language AI翻译
  作者：Hasan-Aslih, Siwar; Idan, Orly; Willer, Robb; Halperin, Eran
  作者单位：Stanford University; Reichman University; Hebrew University of Jerusalem
  摘要：In ethnically and linguistically diverse societies, disadvantaged groups often face pressures to acquire and speak the advantaged group's language to achieve social inclusion and economic mobility. This work investigates how using the advantaged group's language affects disadvantaged group members' in -group pride and collective self- esteem, relative to using their native language. Across six experimental studies involving Palestinian citizens of Israel (total N = 1,348), we test two competin...
• Excessive nucleic acid R- loops induce mitochondria- dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation AI翻译
  作者：Yang, Xu; Lia, Guilin; Loud, Pengbo; Zhang, Mingxin; Yao, Kai; Xiao, Jintao; Chen, Yiqian; Xu, Jiuzhi; Tian, Shengyuan; Deng, Min; Pan, Yuwei; Li, Mengzhen; Wu, Xi; Liu, Ruiqi; Shi, Xiaojing; Tian, Yuhua; Yu, Lu; Ke, Hao; Jiao, Baowei; Cong, Yingzi; Plikus, Maksim V.; Liu, Xiaowei; Yu, Zhengquan; Lv, Cong
  作者单位：Zhengzhou University; China Agricultural University; Ankang University; Central South University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Northwestern University; Feinberg School of Medicine; University of California System; University of California Irvine; China Agricultural University
  摘要：Oxidative stress, which can be activated by a variety of environmental risk factors, has been implicated as an important pathogenic factor for inflammatory bowel disease (IBD). However, how oxidative stress drives IBD onset remains elusive. Here, we found that oxidative stress was strongly activated in inflamed tissues from both ulcerative colitis patients and Crohn's disease patients, and it caused nuclear-to-cytosolic TDP-43 transport and a reduction in the TDP-43 protein level. To investiga...
• Linking vertical movements of large pelagic predators with distribution patterns of biomass in the open ocean (vol 120, e2306357, 2023) AI翻译
  作者：Braun, Camrin D.; Della Penna, Alice; Arostegui, Martin C.; Afonso, Pedro; Berumen, Michael L.; Block, Barbara A.; Brown, Craig A.; Fontes, Jorge; Furtado, Miguel; Gallagher, Austin J.; Gaube, Peter; Golet, Walter J.; Kneebone, Jeff; Macena, Bruno C. L.; Muciente, Gonzalo; Orbesen, Eric S.; Queiroz, Nuno; Shea, Brendan D.; Schratwieser, Jason; Sims, David W.; Skomal, Gregory B.; Snodgrass, Derke; Thorrold, Simon R.