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作者：Bavisotto, Celeste Caruso; Bucchieri, Fabio; Cappello, Francesco
作者单位：University of Palermo
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作者：Beavan, Alan; Sananes, Maria Rosa Domingo -; Mcinerney, James O.
作者单位：University of Nottingham; University of Nottingham
摘要：Pangenomes exhibit remarkable variability in many prokaryotic species, much of which is maintained through the processes of horizontal gene transfer and gene loss. Repeated acquisitions of near- identical homologs can easily be observed across pangenomes, leading to the question of whether these parallel events potentiate similar evolutionary trajectories, or whether the remarkably different genetic backgrounds of the recipients mean that postacquisition evolutionary trajectories end up being ...
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作者：Iyer, Siddhant; Collier, Eleanor; Broom, Timothy W.; Finn, Emily S.; Meyer, Meghan L.
作者单位：Columbia University; University of California System; University of California Riverside; Dartmouth College
摘要：Focusing on the upside of negative events often promotes resilience. Yet, the underlying mechanisms that allow some people to spontaneously see the good in the bad remain unclear. The broaden- and- build theory of positive emotion has long suggested that positive affect, including positivity in the face of negative events, is linked to idiosyncratic thought patterns (i.e., atypical cognitive responses). Yet, evidence in support of this view has been limited, in part, due to difficulty in measu...
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作者：Baoa, JieJ.; Zhang, Dayou; Zhang, Shaoting; Gagliardid, Laura; Truhlara, Donald G.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Nankai University; University of Chicago; University of Chicago
摘要：Multiconfiguration pair- density functional theory (MC-PDFT) was proposed a decade ago, but it is still in the early stage of density functional development. MC-PDFT uses functionals that are called on- top functionals; they depend on the density and the on- top pair density. Most MC-PDFT calculations to date have been unoptimized translations of generalized gradient approximations (GGAs) of Kohn-Sham density functional theory (KS-DFT). A hybrid MC-PDFT has also been developed, in which one in...
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作者：Huang, Kai - Yu; Chung, Hee Jung; Kong, Hyunjoon
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Chan Zuckerberg Initiative (CZI)
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作者：Alexander, Tyler D.; Tymanskyj, Stephen; Kennedy, Kyle J.; Kaczmarek, Leonard K.; Covarrubias, Manuel
作者单位：Thomas Jefferson University; Thomas Jefferson University; Yale University; Yale University
摘要：by June accepted Use- dependent spike broadening (UDSB) results from inactivation of the voltage- gated K+ (Kv) channels that regulate the repolarization of the action potential. However, the specific signaling and molecular processes that modulate UDSB have remained elusive. Here, we applied an adeno- associated viral vector approach and dynamic clamping to conclusively demonstrate how multisite phosphorylation of the N- terminal inactivation domain (NTID) of the Kv3.4 channel modulates UDSB ...
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作者：Bottorff, Juliet; Padgett, Sydney; Turrigiano, Gina G.
作者单位：Brandeis University; Brandeis University
摘要：Bidirectional homeostatic plasticity allows neurons and circuits to maintain stable firing in the face of developmental or learning- induced perturbations. In the primary visual cortex (V1), upward firing rate homeostasis (FRH) only occurs during active wake (AW) and downward during sleep, but how this behavioral state- dependent gating is accomplished is unknown. Here, we focus on how AW enables upward FRH in V1 of juvenile Long Evans rats. A major difference between quiet wake (QW), when upw...
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作者：Tekseth, Kim Robert; Mirzaei, Fazel; Lukic, Bratislav; Chattopadhyay, Basab; Breiby, Dag Werner
作者单位：Norwegian University of Science & Technology (NTNU); European Synchrotron Radiation Facility (ESRF); University of South-Eastern Norway
摘要：Slow multiphase flow in porous media is intriguing because its underlying dynamics is almost deterministic, yet depends on a hierarchy of spatiotemporal processes. There has been great progress in the experimental study of such multiphase flows, but three- dimensional (3D) microscopy methods probing the pore scale fluid dynamics with millisecond resolution have been lacking. Yet, it is precisely at these length and time scales that the crucial pore filling events known as Haines jumps take pla...
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作者：Waintal, Xavier
作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
摘要：Quantum computers have been proposed to solve a number of important problems such as discovering new drugs, new catalysts for fertilizer production, breaking encryption protocols, optimizing financial portfolios, or implementing new artificial intelligence applications. Yet, to date, a simple task such as multiplying 3 by 5 is beyond existing quantum hardware. This article examines the difficulties that would need to be solved for quantum computers to live up to their promises. I discuss the w...
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作者：Li, Jianing
作者单位：Purdue University System; Purdue University
