2024

最新文章

• Membralin is required for maize development and defines a branch of the endoplasmic reticulum-associated degradation pathway in plants AI翻译
  作者：Liu, Baiyu; Xu, Changzheng; He, Qiuxia; Zhang, Ke; Qi, Shoumei; Jin, Zhe; Cheng, Wen; Ding, Zhaohua; Chen, Donghua; Zhao, Xiangyu; Zhang, Wei; Zhang, Kewei; Li, Kunpeng
  作者单位：Shandong University; Southwest University - China; Qilu University of Technology; Shandong Academy of Agricultural Sciences; Shandong Agricultural University
  摘要：Endoplasmic reticulum (ER)-associated degradation (ERAD) plays key roles in controlling protein levels and quality in eukaryotes. The Ring Finger Protein 185 (RNF185)/ membralin ubiquitin ligase complex was recently identified as a branch in mammals and is essential for neuronal function, but its function in plant development is unknown. Here, we report the map- based cloning and characterization of Narrow Leaf and Dwarfism 1 (NLD1), which encodes the ER membrane-localized protein membralin an...
• New voices for a better society (vol 121, e2404579121, 2024) AI翻译
  作者：Diem, Stephanie J.; Bayon, Baindu L.; Mahmoud, Hussam; Garcia-Cazarin, Mary L.; Martin, Michael J.; Rittschof, Clare C.; Silveyra, Patricia; Gurkan, Umut A.; Boland-Reeves, Alison; Najib, Dalal; Wasson, Flannery
  作者单位：National Academies of Sciences, Engineering & Medicine; University of Wisconsin System; University of Wisconsin Madison; Saint Mary's College of California; Colorado State University System; Colorado State University Fort Collins; University of Kentucky; Indiana University System; Indiana University Bloomington; University System of Ohio; Case Western Reserve University; National Academies of Sciences, Engineering & Medicine
• cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization AI翻译
  作者：Ho, Diana M.; Shaban, Muhammad; Mahmood, Faisal; Ganguly, Payel; Todeschini, Leonardo; Van Vactor, David; Artavanis-Tsakonas, Spyros
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Cytoplasmic mislocalization and aggregation of TDP - 43 protein are hallmarks of amyotrophic lateral sclerosis (ALS) and are observed in the vast majority of both familial and sporadic cases. How these two interconnected processes are regulated on a molecular level, however, remains enigmatic. Genome - wide screens for modifiers of the ALS - associated genes TDP - 43 and FUS have identified the phospholipase D (Pld) pathway as a key regulator of ALS - related phenotypes in the fruit fly Drosop...
• Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry AI翻译
  作者：Jones, Natalie H.; Liu, Qiwen; Urnavicius, Linas; Dahan, Noa E.; Vostal, Lauren E.; Kapoor, Tarun M.; Arkin, Michelle R.; Cheng, Yifan
  作者单位：Rockefeller University; Rockefeller University
  摘要：The loss of function of AAA (ATPases associated with diverse cellular activities) mechanoenzymes has been linked to diseases, and small molecules that activate these proteins can be powerful tools to probe mechanisms and test therapeutic hypotheses. Unlike chemical inhibitors that can bind a single conformational state to block enzyme function, activator binding must be permissive to different conformational states needed for mechanochemistry. However, we do not know how AAA proteins can be ac...
• Limited intraspecific variation in drought resistance along a pronounced tropical rainfall gradient AI翻译
  作者：Comita, Liza S.; Jones, F. Andrew; Manzane-Pinzon, Eric J.; Alvarez-Cansino, Leonor; Ceron-Souza, Ivania; Contreras, Blexein; Jaen-Barrios, Nelson; Ferro, Natalie; Engelbrecht, Bettina M. J.
  作者单位：Yale University; Smithsonian Institution; Smithsonian Tropical Research Institute; Oregon State University; Universidad Tecnologica de Panama; University of Sevilla; University of Bayreuth; Corporacion Colombiana de Investigacion Agropecuaria, AGROSAVIA; Universidade Estadual de Campinas; Universidade de Sao Paulo
  摘要：Assessing within - species variation in response to drought is crucial for predicting species' responses to climate change and informing restoration and conservation efforts, yet experimental data are lacking for the vast majority of tropical tree species. We assessed intraspecific variation in response to water availability across a strong rainfall gradient for 16 tropical tree species using reciprocal transplant and common garden field experiments, along with measurements of gene flow and ke...
• Charge barriers in the kidney elimination of engineered nanoparticles AI翻译
  作者：Huang, Yingyu; Yu, Mengxiao; Zheng, Jie
  作者单位：University of Texas System; University of Texas Dallas
  摘要：The renal elimination pathway is increasingly harnessed to reduce nonspecific accumulation of engineered nanoparticles within the body and expedite their clinical applications. While the size of nanoparticles is recognized as crucial for their passive filtration through the glomerulus due to its limited pore size, the influence of nanoparticle charge on their transport and interactions within the kidneys remains largely elusive. Herein, we report that the proximal tubule and peritubular capill...
• Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies AI翻译
  作者：Nebo, Ikenna David; Frew, John W.; Gudjonsson, Johann E.; Petukhova, Lynn
  作者单位：Columbia University; Ingham Institute for Applied Medical Research; University of New South Wales Sydney; Liverpool Hospital; University of Michigan System; University of Michigan; New York University; New York University
• Compositions of iron- meteorite parent bodies constrain the structure of the protoplanetary disk AI翻译
  作者：Zhang, Bidong; Chabot, Nancy L.; Rubin, Alan E.
  作者单位：University of California System; University of California Los Angeles; Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory
  摘要：Magmatic iron - meteorite parent bodies are the earliest planetesimals in the Solar System, and they preserve information about conditions and planet - forming processes in the solar nebula. In this study, we include comprehensive elemental compositions and fractional - crystallization modeling for iron meteorites from the cores of five differentiated asteroids from the inner Solar System. Together with previous results of metallic cores from the outer Solar System, we conclude that asteroidal...
• The decision of male medaka to mate or fight depends on two complementary androgen signaling pathways AI翻译
  作者：Nishiike, Yuji; Okubo, Kataaki
  作者单位：University of Tokyo
  摘要：Adult male animals typically court and attempt to mate with females, while attacking other males. Emerging evidence from mice indicates that neurons expressing the estrogen receptor ESR1 in behaviorally relevant brain regions play a central role in mediating these mutually exclusive behavioral responses to conspecifics. However, the findings in mice are unlikely to apply to vertebrates in general because, in many species other than rodents and some birds, androgens-rather than estrogens-have b...
• Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus AI翻译
  作者：Sengupta, Anirban; Mishra, Arabinda; Wang, Feng; Chen, Li Min; Gore, John C.
  作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University
  摘要：We report the reliable detection of reproducible patterns of blood- oxygenationlevel- dependent (BOLD) MRI signals within the white matter (WM) of the spinal cord during a task and in a resting state. Previous functional MRI studies have shown that BOLD signals are robustly detectable not only in gray matter (GM) in the brain but also in cerebral WM as well as the GM within the spinal cord, but similar signals in WM of the spinal cord have been overlooked. In this study, we detected BOLD signa...