-
作者：Lee, Tsung- Yen; Lam, Lam; Patel-Tupper, Dhruv; Roy, Partha Pratim; Ma, Sophia A.; Lam, Henry E.; DeMott, Aviva Lucas-; Karavolias, Nicholas G.; Iwai, Masakazu; Niyogi, Krishna K.; Fleming, Graham R.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley
摘要：Zeaxanthin (Zea) is a key component in the energy- dependent, rapidly reversible, non- photochemical quenching process (qE) that regulates photosynthetic light harvesting. Previous transient absorption (TA) studies suggested that Zea can participate in direct quenching via chlorophyll (Chl) to Zea energy transfer. However, the contamination of intrinsic exciton-exciton annihilation (EEA) makes the assignment of TA signal ambiguous. In this study, we present EEA-free TA data using Nicotiana ben...
-
作者：Mitchell, Sharon E.; Simpson, Megan; Coulet, Lena; Gouedard, Solenn; Hambly, Catherine; Morimoto, Juliano; Allison, David B.; Speakman, John R.
作者单位：University of Aberdeen; Institut Agro; University of Aberdeen; Universidade Federal do Parana; Indiana University System; Indiana University Bloomington; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; China Medical University
摘要：The disposable soma theory (DST) posits that organisms age and die because of a direct trade- off in resource allocation between reproduction and somatic maintenance. DST predicts that investments in reproduction accentuate somatic damage which increase senescence and shortens lifespan. Here, we directly tested DST predictions in breeding and nonbreeding female C57BL/6J mice. We measured reproductive outputs, body composition, daily energy expenditure, and oxidative stress at peak lactation an...
-
作者：Fandino, Richard A.; Brady, Noah K.; Chatterjee, Martik; Mcdonald, Jeanne M. C.; Livraghi, Luca; van der Burg, Karin R. L.; Mazo-Vargas, Anyi; Markenscoff-Papadimitriou, Eirene; Reed, Robert D.
作者单位：Cornell University; George Washington University; Clemson University; Cornell University
摘要：Long noncoding RNAs (lncRNAs) are transcribed elements increasingly recognized for their roles in regulating gene expression. Thus far, however, we have little understanding of how lncRNAs contribute to evolution and adaptation. Here, we show that a conserved lncRNA, ivory, is an important color patterning gene in the buckeye butterfly Junonia coenia. ivory overlaps with cortex, a locus linked to multiple cases of crypsis and mimicry in Lepidoptera. Along with a companion paper by Livraghi et ...
-
作者：Liang, Xing; Zhao, Yuping; Yan, Jun; Zhang, Qian; James, Tony D.; Lin, Weiying
作者单位：Guangxi University; University of Bath; Henan Normal University
摘要：Deciphering the dynamic mechanism of ferroptosis can provide insights into pathogenesis, which is valuable for disease diagnosis and treatment. However, due to the lack of suitable time- resolved mechanosensitive tools, researchers have been unable to determine the membrane tension and morphology of the plasma membrane and the nuclear envelope during ferroptosis. With this research, we propose a rational strategy to develop robust mechanosensitive fluorescence lifetime probes which can facilit...
-
作者：Abu-Remaileh, Muhannad; Persky, Nicole S.; Lee, Yenarae; Root, David E.; Kaelin Jr, William G.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Howard Hughes Medical Institute
摘要：Loss- of- function germline von Hippel-Lindau (VHL) tumor suppressor mutations cause VHL disease, which predisposes individuals to kidney cancer, hemangioblastomas, and paragangliomas. The risk that a given VHL disease family will manifest some or all these tumor types is profoundly influenced by the VHL allele it carries. For example, almost all VHL disease families that develop paraganglioma have missense VHL mutations. VHL families with null VHL alleles develop kidney cancer and hemangiobla...
-
作者：Khetchoumian, Konstantin; Sochodolsky, Kevin; Lafont, Chrystel; Gouhier, Arthur; Bemmo, Amandine; Kherdjemil, Yacine; Kmita, Marie; Le Tissier, Paul; Mollard, Patrice; Christian, Helen; Drouin, Jacques
作者单位：Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); University of Edinburgh; University of Oxford
摘要：Organ architecture is established during development through intricate cell-cell communication mechanisms, yet the specific signals mediating these communications often remain elusive. Here, we used the anterior pituitary gland that harbors different interdigitated hormone- secreting homotypic cell networks to dissect cell-cell communication mechanisms operating during late development. We show that blocking differentiation of corticotrope cells leads to pituitary hypoplasia with a major effec...
-
作者：Liccardo, Federica; Morstein, Johannes; Lin, Ting-Yu; Pampel, Julius; Lang, Di; Shokat, Kevan M.; Irannejad, Roshanak
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco
摘要：Gprotein- coupled receptors (GPCRs) regulate several physiological and pathological processes and represent the target of approximately 30% of Food and Drug Administration- approved drugs. GPCR- mediated signaling was thought to occur exclusively at the plasma membrane. However, recent studies have unveiled their presence and function at subcellular membrane compartments. There is a growing interest in studying compartmentalized signaling of GPCRs. This requires development of tools to separat...
-
作者：Jiang, Hongda; Wang, Shenshen
作者单位：University of California System; University of California Los Angeles
摘要：To respond and adapt, cells use surface receptors to sense environmental cues. While biochemical signal processing inside the cell is studied in depth, less is known about how physical processes during cell-cell contact impact signal acquisition. New experiments found that fast-evolving immune B cells in germinal centers (GCs) apply force to acquire antigen clusters prior to internalization, suggesting adaptive benefits of physical information extraction. We present a theory of stochastic anti...
-
作者：Kim, Youngdoo; McInnes, Joseph; Kim, Jiyoen; Liang, Yan Hong Wei; Veeraragavan, Surabi; Garza, Alexandra Rae; Belfort, Benjamin David Webst; Arenkiel, Benjamin; Samaco, Rodney; Zoghbi, Huda Yahya
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Howard Hughes Medical Institute
摘要：Parkinson's disease (PD) is typically a sporadic late- onset disorder, which has made it difficult to model in mice. Several transgenic mouse models bearing mutations in SNCA, which encodes alpha- Synuclein (alpha- Syn), have been made, but these lines do not express SNCA in a physiologically accurate spatiotemporal pattern, which limits the ability of the mice to recapitulate the features of human PD. Here, we generated knock- in mice bearing the G51D SNCA mutation. After establishing that th...
-
作者：Li, Wanqian; He, Siyuan; Tan, Jun; Li, Na; Zhao, Chenyang; Wang, Xiaotang; Zhang, Zhi; Liu, Jiangyi; Huang, Jiaxing; Li, Xingran; Zhou, Qian; Hu, Ke; Yang, Peizeng; Hou, Shengping
作者单位：Chongqing Medical University; Capital Medical University; Capital Medical University
摘要：Uveitis is a vision- threatening disease primarily driven by a dysregulated immune response, with retinal microglia playing a pivotal role in its progression. Although the transcription factor EGR2 is known to be closely associated with uveitis, including Vogt-Koyanagi-Harada disease and Behcet's disease, and is essential for maintaining the dynamic homeostasis of auto- immunity, its exact role in uveitis remains unclear. In this study, diminished EGR2 expression was observed in both retinal m...
