2024

最新文章

• Atomic observation and structural evolution of covalent organic framework rotamers AI翻译
  作者：Zeng, Tengwu; Ling, Yang; Jiang, Wentao; Yao, Xuan; Tao, Yu; Liu, Shan; Liu, Huiyu; Yang, Tieying; Wen, Wen; Jiang, Shan; Zhao, Yingbo; Ma, Yanhang; Zhang, Yue - Biao
  作者单位：ShanghaiTech University; ShanghaiTech University; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; ShanghaiTech University
  摘要：Dynamic 3D covalent organic frameworks (COFs) have shown concerted structural transformation and adaptive gas adsorption due to the conformational diversity of organic linkers. However, the isolation and observation of COF rotamers constitute undergoing challenges due to their comparable free energy and subtle rotational energy barrier. Here, we report the atomic-level observation and structural evolution of COF rotamers by cryo-3D electron diffraction and synchrotron powder X-ray diffraction....
• Reply to Polizzi and Dowd: Within- country counterfactual reveals importance of retirement age mortality in addition to established concern about working ages AI翻译
  作者：Abrams, Leah R.; Myrskyla, Mikko; Mehta, Neil K.
  作者单位：Tufts University; Max Planck Society; University of Helsinki; University of Texas System; University of Texas Medical Branch Galveston
• CD73 contributes to the pathogenesis of fusion-negative rhabdomyosarcoma through the purinergic signaling pathway AI翻译
  作者：Hernandez, Karla Cano; Shah, Akansha M.; Lopez, Victor A.; Tagliabracci, Vincent S.; Chen, Kenian; Xu, Lin; Bassel-Duby, Rhonda; Olson, Eric N.; Liu, Ning
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children and adolescents. Fusion-negative RMS (FN-RMS) accounts for more than 80% of all RMS cases. The long-term event-free survival rate for patients with high-grade FN-RMS is below 30%, highlighting the need for improved therapeutic strategies. CD73 is a 5' ectonucleotidase that hydrolyzes AMP to adenosine and regulates the purinergic signaling pathway. We found that CD73 is elevated in FN-RMS tumors that express high ...
• Interlayer engineering of Fe3GeTe2: From 3D superlattice to 2D monolayer AI翻译
  作者：Wu, Yecun; Wang, Bai Yang; Yu, Yijun; Li, Yanbin; Ribeiro, Henrique B.; Wang, Jierong; Xu, Rong; Liu, Yunzhi; Ye, Yusheng; Zhou, Jiawei; Ke, Feng; Harbola, Varun; Heinz, Tony F.; Hwang, Harold Y.; Cui, Yi
  作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University
  摘要：We acknowledge Dr. Leo Yu and Dr. Monique Tie for helping set up MOKE measurement. This work was supported by the U.S. Department of Energy (DOE), Office of Basic Energy Sciences, Division of Materials Sciences and Engineering (Contract No. DE-AC02-76SF00515). Part of this work was performed at the Stanford Nano Shared Facilities (SNSF), supported by the National Science Foundation under award ECCS-1542152.
• A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction AI翻译
  作者：Clatot, Jerome; Currin, Christopher B.; Liang, Qiansheng; Pipatpolkai, Tanadet; Massey, Shavonne L.; Helbig, Ingo; Delemotte, Lucie; Vogels, Tim P.; Covarrubias, Manuel; Goldberg, Ethan M.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Institute of Science & Technology - Austria; Thomas Jefferson University; Thomas Jefferson University; Royal Institute of Technology; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania
  摘要：De novo heterozygous variants in KCNC2 encoding the voltage-gated potassium (K+) channel subunit Kv3.2 are a recently described cause of developmental and epileptic encephalopathy (DEE). A de novo variant in KCNC2 c.374G > A (p.Cys125Tyr) was identified via exome sequencing in a patient with DEE. Relative to wild-type Kv3.2, Kv3.2-p.Cys125Tyr induces K+ currents exhibiting a large hyperpolarizing shift in the voltage dependence of activation, accelerated activation, and delayed deactivation co...
• Fossil evidence sheds light on sexual selection during the early evolution of birds AI翻译
  作者：Zhou, Yibo; Pan, Yanhong; Wang, Min; Wang, Xiaoli; Zheng, Xiaoting; Zhou, Zhonghe
  作者单位：Nanjing University; Nanjing University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Linyi University
  摘要：The impact of sexual selection on the evolution of birds has been widely acknowledged. Although sexual selection has been hypothesized as a driving force in the occurrences of numerous morphological features across theropod evolution, this hypothesis has yet to be comprehensively tested due to challenges in identifying the sex of fossils and by the limited sample size. Confuciusornis sanctus is arguably the best-known early avialan and is represented by thousands of well-preserved specimens fr...
• Gp130-HIF1α axis-induced vascular damage is prevented by the short- term inhibition of IL-6 receptor signaling AI翻译
  作者：Kang, Sujin; Onishi, Shinya; Ling, Zhenzhen; Inoue, Hitomi; Zhang, Yingying; Chang, Hao; Zhao, Hui; Wang, Tong; Okuzaki, Daisuke; Matsuura, Hiroshi; Takamatsu, Hyota; Oda, Jun; Kishimoto, Tadamitsu
  作者单位：University of Osaka; University of Osaka; University of Osaka; University of Osaka; University of Osaka
  摘要：Protection against endothelial damage is recognized as a frontline approach to preventing the progression of cytokine release syndrome (CRS). Accumulating evidence has demonstrated that interleukin-6 (IL 6) promotes vascular endothelial damage during CRS, although the molecular mechanisms remain to be fully elucidated. Targeting IL 6 receptor signaling delays CRS progression; however, current options are limited by persistent inhibition of the immune system. Here, we show that endothelial IL 6...
• ALK signaling primes the DNA damage response sensitizing ALK- driven neuroblastoma to therapeutic ATR inhibition AI翻译
  作者：Borenas, Marcus; Umapathy, Ganesh; Lind, Dan E.; Lai, Wei -Yun; Guan, Jikui; Johansson, Joel; Jennische, Eva; Schmidt, Alexander; Kurhe, Yeshwant; Gabre, Jonatan L.; Aniszewska, Agata; Stromberg, Anneli; Bemark, Mats; Hall, Michael N.; Van den Eynden, Jimmy; Hallberg, Bengt; Palmer, Ruth H.
  作者单位：University of Gothenburg; Ghent University; University of Gothenburg; Sahlgrenska University Hospital; University of Basel
  摘要：High -risk neuroblastoma (NB) is a significant clinical challenge. MYCN and Anaplastic Lymphoma Kinase (ALK), which are often involved in high -risk NB, lead to increased replication stress in cancer cells, suggesting therapeutic strategies. We previously identified an ATR (ataxia telangiectasia and Rad3- related)/ALK inhibitor (ATRi/ALKi) combination as such a strategy in two independent genetically modified mouse NB models. Here, we identify an underlying molecular mechanism, in which ALK si...
• B56δ long- disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations AI翻译
  作者：Wu, Cheng- Guo; Balakrishnan, Vijaya K.; Merrill, Ronald A.; Parihar, Pankaj S.; Konovolov, Kirill; Chen, Yu- Chia; Xu, Zhen; Wei, Hui; Sundaresan, Ramya; Cui, Qiang; Wadzinski, Brian E.; Swingle, Mark R.; Musiyenko, Alla; Chung, Wendy K.; Honkanen, Richard E.; Suzuki, Aussie; Huang, Xuhui; Strack, Stefan; Xing, Yongna
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Iowa; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Iowa; Boston University; Vanderbilt University; University of South Alabama; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Intrinsically disordered regions (IDR) and short linear motifs (SLiMs) play pivotal roles in the intricate signaling networks governed by phosphatases and kinases. B568 (encoded by PPP2R5D) is a regulatory subunit of protein phosphatase 2A (PP2A) with long IDRs that harbor a substrate- mimicking SLiM and multiple phosphorylation sites. De novo missense mutations in PPP2R5D cause intellectual disabilities (ID), macrocephaly, Parkinsonism, and a broad range of neurological symptoms. Our single- ...
• Recognizability and timing of infant vocalizations relate to fluctuations in heart rate AI翻译
  作者：Borjon, Jeremy I.; Sahoo, Manash K.; Rhodes, Katherine D.; Lipschutz, Rebecca; Bick, Johanna R.
  作者单位：University of Houston System; University of Houston; University of Houston System; University of Houston; University of Houston System; University of Houston; Emory University
  摘要：For human infants, producing recognizable speech is more than a cognitive process. It is a motor skill that requires infants to learn to coordinate multiple muscles of varying functions across their body. This coordination is directly linked to ongoing fluctuations in heart rate; a physiological process that can scaffold behavior. We investigated whether ongoing fluctuations in heart rate coincide with vocal production and word formation in 24-mo-old infants. Infants were most likely to produc...