2024

最新文章

• Simulating institutional heterogeneity in sustainability science AI翻译
  作者：Davidson, Michael R.; Filatova, Tatiana; Peng, Wei; Verbeek, Liz; Kucuksayacigil, Fikri
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Delft University of Technology; Princeton University; Princeton University
  摘要：Sustainability outcomes are influenced by the laws and configurations of natural and engineered systems as well as activities in socio- economic systems. An important subset of human activity is the creation and implementation of institutions, formal and informal rules shaping a wide range of human behavior. Understanding these rules and codifying them in computational models can provide important missing insights into why systems function the way they do (static) as well as the pace and struc...
• High life satisfaction reported among small- scale societies with low incomes AI翻译
  作者：Galbraith, Eric D.; Barrington-leigh, Christopher; Minarro, Sara; Fernandez, Santiago Alvarez-; Attoh, Emmanuel M. N. A. N.; Benyeia, Petra; Calvet-mira, Laura; Carmona, Rosario; Chakauya, Rumbidzayi; Chen, Zhuo; Chengula, Fasco; Fernandez-Llamazares, Alvaro; Garcia-del-amo, David; Glauser, Marcos; Huanca, Tomas; Izquierdo, Andrea E.; Junqueira, Andre B.; Lanker, Marisa; Li, Xiaoyue; Mariel, Juliette; Miara, Mohamed D.; Porcher, Vincent; Porcuna-Ferrer, Anna; Schlingmann, Anna; Seidler, Reinmar; Shrestha, Uttam Babu; Singh, Priyatma; Torrents-Tico, Miquel; Ulambayar, Tungalag; Wu, Rihan; Reyes-Garcia, Victoria
  作者单位：ICREA; McGill University; McGill University; McGill University; Wageningen University & Research; CGIAR; International Water Management Institute (IWMI); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Economia, Geografia y Demografia (IEGD); Autonomous University of Barcelona; Pontificia Universidad Catolica de Chile; University of South Africa; University of Helsinki; University of Dar es Salaam; University of Helsinki; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Cordoba; University of Wisconsin System; University of Wisconsin Madison; CIRAD; Universite Ibn Khaldoun Tiaret; Universite Ibn Khaldoun Tiaret; University of Massachusetts System; University of Massachusetts Boston; University of Helsinki; Peking University
  摘要：Global polls have shown that people in high- income countries generally report being more satisfied with their lives than people in low- income countries. The persistence of this correlation, and its similarity to correlations between income and life satisfaction within countries, could lead to the impression that high levels of life satisfaction can only be achieved in wealthy societies. However, global polls have typically overlooked small- scale, nonindustrialized societies, which can provi...
• Underlying and proximate drivers of biodiversity changes in Mesoamerican biosphere reserves AI翻译
  作者：Auliz-Ortiz, Daniel Martin; Benitez-Malvido, Julieta; Arroyo- Rodriguez, Victor; Dirzo, Rodolfo; Perez-Farrera, Miguel Angel; Luna-Reyes, Roberto; Mendoza, Eduardo; Alvarez-Anorve, Mariana Yolotl; Alvarez-Sanchez, Javier; Arias-Ataide, Dulce Maria; Avila-Cabadilla, Luis Daniel; Botello, Francisco; Braasch, Marco; Casas, Alejandro; Campos-Villanueva, Delfino Alvaro; Cedeno-Vazquez, Jose Rogelio; Chavez-Tovar, Jose Cuauhtemoc; Coates, Rosamond; Dechnik-Vazquez, Yanus; Arizmendi, Maria del Coro; Dias, Pedro Americo; Dorado, Oscar; Enriquez, Paula; Escalona-Seguras, Griselda; Farias-Gonzalez, Veronica; Favilat, Mario E.; Garcia, Andres; Garcia-Moralesv, Leccinum Jesus; Gavito-Perez, Fernando; Gomez-Domingueze, Hector; Gonzalez-Garcia, Fernando; Gonzalez-Zamora, Arturo; Cuevas-Guzman, Ramon; Haro-Belchez, Enrique; Hernandez-Huerta, Arturo Heriberto; Hernandez-Ordonez, Omar; Horvat, Anna; Ibarra-Manriquez, Guillermo; Lavin-Murcio, Pablo Antonio; Lira-Saade, Rafael; Lopez-Diaze, Karime; Macswiney, G. M. Cristina; Mandujano, Salvador; Martinez-Camilo, Ruben; Martinez-Avaloshh, Jose Guadalupe; Martinez-Melendezii, Nayely; Monroy-Ojeda, Alan; Mora, Francisco; Mora-Olivo, Arturo; Muench, Carlos; Pena-Mondragon, Juan L.; Percino-Daniel, Ruth; Ramirez-Marcial, Neptali; Reyna-Hurtado, Rafael; Rodriguez-Ruiz, Erick Ruben; Sanchez-Cordero, Victor; Suazo-Ortuno, Ireri; Teran-Juarez, Sergio Alejandro; Valdivieso-Perez, Ingrid Abril; Valencia, Vivian; Valenzuela-Galvan, David; Vargas-Contreras, Jorge Albino; Vazquez-Perez, Jose Raul; Vega-Rivera, Jorge Humberto; Venegas-Barrera, Crystian Sadiel; Martinez-Ramosa, Miguel
  作者单位：Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Stanford University; Stanford University; Universidad Michoacana de San Nicolas de Hidalgo; Universidad Nacional Autonoma de Mexico; Universidad Autonoma del Estado de Morelos; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; El Colegio de la Frontera Sur (ECOSUR); Universidad Autonoma Metropolitana - Mexico; Universidad Nacional Autonoma de Mexico; Universidad Veracruzana; El Colegio de la Frontera Sur (ECOSUR); El Colegio de la Frontera Sur (ECOSUR); Instituto de Ecologia - Mexico; Universidad Nacional Autonoma de Mexico; Instituto de Ecologia - Mexico; Universidad Veracruzana; Universidad de Guadalajara; Instituto de Ecologia - Mexico; Universidad Autonoma de Ciudad Juarez; Universidad Autonoma del Estado de Morelos; Universidad Veracruzana; Universidad Autonoma de Tamaulipas; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Bishops University; Universidad Autonoma del Estado de Morelos
  摘要：Protected areas are of paramount relevance to conserving wildlife and ecosystem contributions to people. Yet, their conservation success is increasingly threatened by human activities including habitat loss, climate change, pollution, and species overexploitation. Thus, understanding the underlying and proximate drivers of anthropogenic threats is urgently needed to improve protected areas' effectiveness, especially in the biodiversity-rich tropics. We addressed this issue by analyzing expert-...
• DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 AI翻译
  作者：Swarnkar, Gaurav; Semenkovich, Nicholas P.; Arra, Manoj; Mims, Dorothy K.; Naqvi, Syeda Kanwal; Peterson, Timothy; Mbalaviele, Gabriel; Wu, Chia- Lung; Abu-Amer, Yousef; Nathan, Carl F.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Rochester; Washington University (WUSTL)
  摘要：Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostasis. In the present study, we demonstrate that DAC elicits potent anti- inflammatory effects and attenuates disease symptoms in several animal models of arthritis. Transcriptomic and epigenomic profiling show that DAC-mediated hypomethylation regulates a wide ...
• Aqueous chemimemristor based on proton- permeable graphene membranes AI翻译
  作者：Wang, Yongkang; Seki, Takakazu; Gkoupidenis, Paschalis; Chen, Yunfei; Nagata, Yuki; Bonn, Mischa
  作者单位：Southeast University - China; Max Planck Society
  摘要：Memristive devices, electrical elements whose resistance depends on the history of applied electrical signals, are leading candidates for future data storage and neuromorphic computing. Memristive devices typically rely on solid - state technology, while aqueous memristive devices are crucial for biology- related applications such as next- generation brain- machine interfaces. Here, we report a simple graphene-based aqueous memristive device with long - term and tunable memory regulated by rev...
• SonoTransformers: Transformable acoustically activated wireless microscale machines AI翻译
  作者：Zhang, Zhiyuan; Shi, Zhan; Ahmed, Daniel; Zhang, Yihui
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Shape transformation, a key mechanism for organismal survival and adaptation, has gained importance in developing synthetic shape- shifting systems with diverse applications ranging from robotics to bioengineering. However, designing and controlling microscale shape- shifting materials remains a fundamental challenge in various actuation modalities. As materials and structures are scaled down to the microscale, they often exhibit size- dependent characteristics, and the underlying physical mec...
• Cell cycle plasticity underlies fractional resistance to palbociclib in ER+/HER2-breast tumor cells AI翻译
  作者：Zikry, Tarek M.; Wolff, Samuel C.; Ranek, Jolene S.; Davis, Harris M.; Naugle, Ander; Luthra, Namit; Whitman, Austin A.; Kedziora, Katarzyna M.; Stallaert, Wayne; Kosorok, Michael R.; Spanheimer, Philip M.; Purvis, Jeremy E.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of North Carolina; University of North Carolina Chapel Hill
  摘要：The CDK4/6 inhibitor palbociclib blocks cell cycle progression in Estrogen receptor- positive, human epidermal growth factor 2 receptor-negative (ER+/HER2-) breast tumor cells. Despite the drug's success in improving patient outcomes, a small percentage of tumor cells continues to divide in the presence of palbociclib-a phenomenon we refer to as fractional resistance. It is critical to understand the cellular mechanisms underlying fractional resistance because the precise percentage of resista...
• Structural phase purification of bulk HfO2:Y through pressure cycling AI翻译
  作者：Musfeldt, J. L.; Singh, Sobhit; Fan, Shiyu; Gu, Yanhong; Xu, Xianghan; Cheong, S. -W.; Liu, Z.; Vanderbilt, David; Rabe, Karin M.
  作者单位：University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville; University of Rochester; University of Rochester; United States Department of Energy (DOE); Brookhaven National Laboratory; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital
  摘要：We combine synchrotron -based infrared absorption and Raman scattering spectroscopies with diamond anvil cell techniques and first -principles calculations to explore the properties of hafnia under compression. We find that pressure drives HfO2:7%Y from the mixed monoclinic (P21/c) + antipolar orthorhombic (Pbca) phase to pure antipolar orthorhombic (Pbca) phase at approximately 6.3 GPa. This transformation is irreversible, meaning that upon release, the material is kinetically trapped in the ...
• Viruses traverse the human proteome through peptide interfaces that can be biomimetically leveraged for drug discovery AI翻译
  作者：Schickin, Laurene Meyniel; Amaudrut, Jerome; Mallinjoud, Pierre; Guillier, Fabrice; Mangeot, Philippe E.; Lines, Laetitia; Aublin-Gex, Anne; Scholtes, Caroline; Punginelli, Claire; Joly, Stephane; Vasseur, Florence; Manet, Evelyne; Gruffat, Henri; Henry, Thomas; Halitim, Fares; Paparin, Jean-Laurent; Machin, Peter; Darteil, Raphael; Sampson, Diane; Mikaelian, Ivan; Lane, Lydie; Navratil, Vincent; Golinelli-Coher, Marie-Pierre; Terzi, Fabiola; Andre, Patrice; Lotteau, Vincent; Vonderscher, Jacky; Meldrum, Eric C.; de Chassey, Benoit
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); UNICANCER; Centre Leon Berard; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Swiss Institute of Bioinformatics; Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
  摘要：We present a drug design strategy based on structural knowledge of protein-protein interfaces selected through virus-host coevolution and translated into highly potential small molecules. This approach is grounded on Vinland, the most comprehensive atlas of virus-human protein-protein interactions with annotation of interacting domains. From this inspiration, we identified small viral protein domains responsible for interaction with human proteins. These peptides form a library of new chemical...
• Manifold fitting with CycleGAN AI翻译
  作者：Yao, Zhigang; Su, Jiaji; Yau, Shing-Tung
  作者单位：National University of Singapore; Tsinghua University; Harvard University
  摘要：Manifold fitting, which offers substantial potential for efficient and accurate modeling, poses a critical challenge in nonlinear data analysis. This study presents an approach that employs neural networks to fit the latent manifold. Leveraging the generative adversarial framework, this method learns smooth mappings between low-dimensional latent space and high-dimensional ambient space, echoing the Riemannian exponential and logarithmic maps. The well-trained neural networks provide estimatio...