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作者：Park, Sohyun; Gordon, Collette T.; Swager, Timothy M.
作者单位：Sungshin Women's University; Massachusetts Institute of Technology (MIT)
摘要：Perfluoroalkyl substances (PFAS), known as forever chemicals, are a growing concern in the sphere of human and environmental health. In response, rapid, reproducible, and inexpensive methods for PFAS detection in the environment and home water supplies are needed. We have developed a simple and inexpensive perfluoroalkyl acid detection method based on an electrically read lateral flow assay (e-LFA). Our method employs a fluorous surfactant formulation with undoped polyaniline (F-PANI) fabricat...
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作者：Anees, Faisal; Montoya, Diego A.; Pisetsky, David S.; Payne, Christine K.
作者单位：Duke University; Duke University; US Department of Veterans Affairs; Veterans Health Administration (VHA); Durham VA Medical Center
摘要：Autoimmune and inflammatory diseases are highly complex, limiting treatment and the development of new therapies. Recent work has shown that cell - free DNA bound to biological microparticles is linked to systemic lupus erythematosus, a prototypic autoimmune disease. However, the heterogeneity and technical challenges associated with the study of biological particles have hindered a mechanistic understanding of their role. Our goal was to develop a well- controlled DNA-particle model system to...
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作者：Chaudhary, Namit; Newby, Alexandra N.; Arral, Mariah L.; Yerneni, Saigopalakrishna S.; Lopresti, Samuel T.; Doerfler, Rose; Petersen, Daria M. Strelkova; Montoya, Catalina; Kim, Julie S.; Fox, Bethany; Coon, Tiffany; Malaney, Angela; Sadovsky, Yoel; Whitehead, Kathryn A.
作者单位：Carnegie Mellon University; Carnegie Mellon University; Carnegie Mellon University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Magee-Womens Research Institute
摘要：Treating pregnancy- related disorders is exceptionally challenging because the threat of maternal and/or fetal toxicity discourages the use of existing medications and hinders new drug development. One potential solution is the use of lipid nanoparticle (LNP) RNA therapies, given their proven efficacy, tolerability, and lack of fetal accumulation. Here, we describe LNPs for efficacious mRNA delivery to maternal organs in pregnant mice via several routes of administration. In the placenta, our ...
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作者：Dai, Panxi; Nie, Ji; Yu, Yan; Wu, Renguang
作者单位：Zhejiang University; Peking University; Peking University; China Meteorological Administration
摘要：The projected changes in the hydrological cycle under global warming remain highly uncertain across current climate models. Here, we demonstrate that the observational past warming trend can be utilized to effectively co1nstrain future projections in mean and extreme precipitation on both global and regional scales. The physical basis for such constraints relies on the relatively constant climate sensitivity in individual models and the reasonable consistency of regional hydrological sensitivi...
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作者：Papastavrou, Nikolaos; Horning, David P.; Joyce, Gerald F.
作者单位：Salk Institute
摘要：An RNA polymerase ribozyme that was obtained by directed evolution can propagate a functional RNA through repeated rounds of replication and selection, thereby enabling Darwinian evolution. Earlier versions of the polymerase did not have sufficient copying fidelity to propagate functional information, but a new variant with improved fidelity can replicate the hammerhead ribozyme through reciprocal synthesis of both the hammerhead and its complement, with the products then being selected for RN...
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作者：Radmand, Afsane; Kim, Hyejin; Beyersdorf, Jared; Dobrowolski, Curtis N.; Zenhausern, Ryan; Paunovska, Kalina; Huayamares, Sebastian G.; Hua, Xuanwen; Han, Keyi; Loughrey, David; Hatit, Marine Z. C.; Del Cid, Ada; Ni, Huanzhen; Shajii, Aram; Li, Andrea; Muralidharan, Abinaya; Peck, Hannah E.; Tiegreen, Karen E.; Jia, Shu; Santangelo, Philip J.; Dahlman, James E.
作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Emory University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
摘要：Adding a cationic helper lipid to a lipid nanoparticle (LNP) can increase lung delivery and decrease liver delivery. However, it remains unclear whether charge- dependent tropism is universal or, alternatively, whether it depends on the component that is charged. Here, we report evidence that cationic cholesterol- dependent tropism can differ from cationic helper lipid- dependent tropism. By testing how 196 LNPs delivered mRNA to 22 cell types, we found that charged cholesterols led to a diffe...
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作者：Babenko, Iaroslav; Kroeger, Nils; Friedrich, Benjamin M.
作者单位：Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden
摘要：The silica -based cell walls of diatoms are prime examples of genetically controlled, species -specific mineral architectures. The physical principles underlying morphogenesis of their hierarchically structured silica patterns are not understood, yet such insight could indicate novel routes toward synthesizing functional inorganic materials. Recent advances in imaging nascent diatom silica allow rationalizing possible mechanisms of their pattern formation. Here, we combine theory and experimen...
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作者：Schmitt, Sylvain; Heuret, Patrick; Troispoux, Valerie; Beraud, Melanie; Cazal, Jocelyn; Chancerel, Emilie; Cravero, Charlotte; Guichoux, Erwan; Lepais, Olivier; Loureiro, Joao; Marande, William; Martin-Ducup, Olivier; Vincent, Gregoire; Chave, Jerome; Plomion, Christophe; Leroy, Thibault; Heuertz, Myriam; Tysklind, Niklas
作者单位：Centre National de la Recherche Scientifique (CNRS); INRAE; AgroParisTech; CIRAD; CIRAD; Universite de Montpellier; CIRAD; Universite de Montpellier; CIRAD; INRAE; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); AgroParisTech; CIRAD; Centre National de la Recherche Scientifique (CNRS); INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite Paris Saclay; CEA; INRAE; Universite de Bordeaux; INRAE; Universidade de Coimbra; INRAE; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Institut de Recherche pour le Developpement (IRD); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; University of Vienna; Universite de Toulouse; Ecole Nationale Veterinaire de Toulouse; INRAE
摘要：Somatic mutations potentially play a role in plant evolution, but common expectations pertaining to plant somatic mutations remain insufficiently tested. Unlike in most animals, the plant germline is assumed to be set aside late in development, leading to the expectation that plants accumulate somatic mutations along growth. Therefore, several predictions were made on the fate of somatic mutations: mutations have generally low frequency in plant tissues; mutations at high frequency have a high...
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作者：David, Kyle T.; Harrison, Marie-Claire; Opulente, Dana A.; Labella, Abigail L.; Wolters, John F.; Zhou, Xiaofan; Shen, Xing-Xing; Groenewald, Marizeth; Pennell, Matt; Hittinger, Chris Todd; Rokas, Antonis
作者单位：Vanderbilt University; Vanderbilt University; University of Wisconsin System; University of Wisconsin Madison; United States Department of Energy (DOE); Villanova University; University of North Carolina; University of North Carolina Charlotte; South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Zhejiang University; University of Southern California; University of Southern California
摘要：The Saccharomycotina yeasts (yeasts hereafter) are a fungal clade of scientific, ecorecords and 96 environmental variables to infer global distribution maps at -1 km2 resolution for 186 yeast species (-15% of described species from 75% of orders) and to test environmental drivers of yeast biogeography and macroecology. We found that predicted yeast diversity hotspots occur in mixed montane forests in temperate climates. Diversity in vegetation type and topography were some of the greatest pred...
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作者：Ran, Maoxi; Du, Bibai; Liu, Wenyuan; Liang, Zhiyan; Liang, Lihong; Zhang, Yayun; Zeng, Lixi; Xing, Mingyang
作者单位：East China University of Science & Technology; Jinan University; East China University of Science & Technology; East China University of Science & Technology; East China University of Science & Technology
摘要：Creating efficient catalysts for simultaneous H2O2 generation and pollutant degradation is vital. Piezocatalytic H2O2 synthesis offers a promising alternative to traditional methods but faces challenges like sacrificial reagents, harsh conditions, and low activity. In this study, we introduce a cobalt- loaded ZnO (CZO) piezocatalyst that efficiently generates H2O2 from H2O and O-2 under ultrasonic (US) treatment in ambient aqueous conditions. The catalyst demonstrates exceptional performance w...
