2024

最新文章

• Essential role of N- terminal SAM regions in STIM1 multimerization and function AI翻译
  作者：Sallinger, Matthias; Humer, Christina; Ong, Hwei Ling; Narayanasamy, Sasirekha; Lin, Qi Tong; Fahrner, Marc; Grabmayr, Herwig; Berlansky, Sascha; Choi, Sean; Schmidt, Tony; Maltan, Lena; Atzgerstorfer, Lara; Niederwieser, Martin; Frischauf, Irene; Romanin, Christoph; Stathopulos, Peter B.; Ambudkar, Indu; Leitner, Romana; Borinenry, Daniel; Schind, Rainer
  作者单位：Johannes Kepler University Linz; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); Western University (University of Western Ontario); Medical University of Graz; University of Luxembourg
  摘要：The single - pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the endoplasmic reticulum (ER) membrane, possesses two main functions: It senses the ER - Ca 2+ concentration and directly binds to the store - operated Ca 2+ channel Orai1 for its activation when Ca 2+ recedes. At high resting ER - Ca 2+ concentration, the ER - luminal STIM1 domain is kept monomeric but undergoes di/multimerization once stores are depleted. Luminal STIM1 multimerization is essential to ...
• Lipid- derived electrophiles inhibit the function of membrane channels during ferroptosis AI翻译
  作者：Van Kessel, Antonius T. M.; Cosa, Gonzalo
  作者单位：McGill University; McGill University
  摘要：The therapeutic targeting of ferroptosis requires full understanding of the molecular mechanism of this regulated cell death pathway. While lipid - derived electrophiles (LDEs), including 4 - hydroxy - 2 - nonenal (4 - HNE), are important biomarkers of ferroptosis, a functional role for these highly reactive species in ferroptotic cell death execution has not been established. Here, through mechanistic characterization of LDE - detoxification impairment, we demonstrate that LDEs mediate altere...
• Nonlethal deleterious mutation-induced stress accelerates bacterial aging AI翻译
  作者：Kohram, Maryam; Sanderson, Amy E.; Loui, Alicia; Thompson, Peyton V.; Vashistha, Harsh; Shomar, Aseel; Oltvai, Zoltan N.; Salman, Hanna
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Technion Israel Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Rochester; Princeton University; Yale University
  摘要：Random mutagenesis, including when it leads to loss of gene function, is a key mechanism enabling microorganisms' long - term adaptation to new environments. However, lossof - function mutations are often deleterious, triggering, in turn, cellular stress and complex homeostatic stress responses, called allostasis, to promote cell survival. Here, we characterize the differential impacts of 65 nonlethal, deleterious single - gene deletions on Escherichia coli growth in three different growth env...
• A finely balanced order-disorder equilibrium sculpts the folding- binding landscape of an antibiotic sequestering protein AI翻译
  作者：Natarajan, Lawanya; De Sciscio, Maria Laura; Nardi, Alessandro Nicola; Sekhar, Ashok; Del Giudice, Alessandra; D'Abramo, Marco; Naganathan, Athi N.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Sapienza University Rome
  摘要：TipA, a MerR family transcription factor from Streptomyces lividans , promotes antibiotic resistance by sequestering broad - spectrum thiopeptide - based antibiotics, thus counteracting their inhibitory effect on ribosomes. TipAS, a minimal binding motif which is expressed as an isoform of TipA, harbors a partially disordered N - terminal subdomain that folds upon binding multiple antibiotics. The extent and nature of the underlying molecular heterogeneity in TipAS that shapes its promiscuous ...
• Landscape fragmentation overturns classical metapopulation thinking AI翻译
  作者：Tao, Yun; Hastings, Alan; Lafferty, Kevin D.; Hanski, Ilkka; Ovaskainen, Otso
  作者单位：University of California System; University of California Santa Barbara; University System of Georgia; University of Georgia; University of California System; University of California Davis; The Santa Fe Institute; United States Department of the Interior; United States Geological Survey; University of California System; University of California Santa Barbara; University of Helsinki; University of Jyvaskyla; Norwegian University of Science & Technology (NTNU)
  摘要：Habitat loss and isolation caused by landscape fragmentation represent a growing threat to global biodiversity. Existing theory suggests that the process will lead to a decline in metapopulation viability. However, since most metapopulation models are restricted to simple networks of discrete habitat patches, the effects of real landscape fragmentation, particularly in stochastic environments, are not well understood. To close this major gap in ecological theory, we developed a spatially expli...
• Three's a crowd: Saccharibacteria episymbiosis modulates phage predation of host bacteria AI翻译
  作者：Lamont, Richard J.
  作者单位：University of Louisville
• Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo AI翻译
  作者：Tang, Vi T.; Xiang, Jie; Chen, Zhimin; McCormick, Joseph; Abbineni, Prabhodh S.; Chen, Xiao-Wei; Hoenerhoff, Mark; Emmer, Brian T.; Khoriaty, Rami; Lin, Jiandie D.; Ginsburg, David
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Loyola University Chicago; Peking University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Proteins carrying a signal peptide and/or a transmembrane domain enter the intracellular secretory pathway at the endoplasmic reticulum (ER) and are transported to the Golgi apparatus via COPII vesicles or tubules. SAR1 initiates COPII coat assembly by recruiting other coat proteins to the ER membrane. Mammalian genomes encode two SAR1 paralogs, SAR1A and SAR1B. While these paralogs exhibit similar to 90% amino acid sequence identity, it is unknown whether they perform distinct or overlapping ...
• Low-latency gravitational wave alert products and their performance at the time of the fourth LIGO-Virgo-KAGRA observing run AI翻译
  作者：Chaudhary, Sushant Sharma; Toivonen, Andrew; Waratkar, Gaurav; Mo, Geoffrey; Chatterjee, Deep; Antier, Sarah; Brockill, Patrick; Coughlin, Michael W.; Essick, Reed; Ghosh, Shaon; Morisaki, Soichiro; Baral, Pratyusava; Baylor, Amanda; Adhikari, Naresh; Brady, Patrick; Davies, Gareth Cabourn; Dal Canton, Tito; Cavaglia, Marco; Creighton, Jolien; Choudhary, Sunil; Chu, Yu-Kuang; Clearwater, Patrick; Davis, Luke; Dent, Thomas; Drago, Marco; Ewing, Becca; Godwin, Patrick; Guo, Weichangfeng; Hanna, Chad; Huxford, Rachael; Harry, Ian; Katsavounidis, Erik; Kovalam, Manoj; Li, Alvin K. Y.; Magee, Ryan; Marx, Ethan; Meacher, Duncan; Messick, Cody; Atkinson, Xan Morice; Pace, Alexander; De Pietri, Roberto; Piotrzkowski, Brandon; Roy, Soumen; Sachdev, Surabhi; Singer, Leo P.; Singh, Divya; Bahcall, Neta; Szczepanczyk, Marek; Tang, Daniel; Trevor, Max; Tsukada, Leo; Villa-Ortega, Veronica; Wen, Linqing; Wysocki, Daniel
  作者单位：University of Missouri System; Missouri University of Science & Technology; University of Minnesota System; University of Minnesota Twin Cities; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Universite Cote d'Azur; Observatoire de la Cote d'Azur; University of Wisconsin System; University of Wisconsin Milwaukee; University of Toronto; University of Toronto; University of Toronto; Montclair State University; University of Tokyo; University of Portsmouth; Universite Paris Cite; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute of Nuclear and Particle Physics (IN2P3); University of Wisconsin System; University of Wisconsin Milwaukee; University of Western Australia; Universidade de Santiago de Compostela; Sapienza University Rome; Istituto Nazionale di Fisica Nucleare (INFN); Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; California Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Portsmouth; University of Parma; Istituto Nazionale di Fisica Nucleare (INFN); FOM National Institute for Subatomic Physics; Utrecht University; University System of Georgia; Georgia Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University System of Maryland; University of Maryland College Park; State University System of Florida; University of Florida; University System of Maryland; University of Maryland College Park
  摘要：Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of...
• Machine learning enables identification of an alternative yeast galactose utilization pathway AI翻译
  作者：Harrison, Marie-Claire; Ubbelohde, Emily J.; LaBella, Abigail L.; Opulente, Dana A.; Wolters, John F.; Zhou, Xiaofan; Shen, Xing-Xing; Groenewald, Marizeth; Hittinger, Chris Todd; Rokas, Antonis
  作者单位：Vanderbilt University; Vanderbilt University; United States Department of Energy (DOE); University of Wisconsin System; University of Wisconsin Madison; University of North Carolina; University of North Carolina Charlotte; Villanova University; South China Agricultural University; Zhejiang University
  摘要：How genomic differences contribute to phenotypic differences is a major question in biology. The recently characterized genomes, isolation environments, and qualitative species (nearly all known) in the yeast subphylum Saccharomycotina provide a powerful, yet complex, dataset for addressing this question. We used a random forest algorithm trained on these genomic, metabolic, and environmental data to predict growth on several carbon sources with high accuracy. Known structural genes involved i...
• Mapping seasonal migration in a songbird hybrid zone --heritability, genetic correlations, and genomic patterns linked to speciation AI翻译
  作者：Justen, Hannah C.; Easton, Wendy E.; Delmore, Kira E.
  作者单位：Environment & Climate Change Canada
  摘要：Seasonal migration is a widespread behavior relevant for adaptation and speciation, yet knowledge of its genetic basis is limited. We leveraged advances in tracking and sequencing technologies to bridge this gap in a well - characterized hybrid zone between songbirds that differ in migratory behavior. Migration requires the coordinated action of many traits, including orientation, timing, and wing morphology. We used genetic mapping to show these traits are highly heritable and genetically cor...