2024

最新文章

• Thirst- driven hygrosensory suppression promotes water seeking in Drosophila AI翻译
  作者：Chu, Li-An; Tai, Chu-Yi; Chiang, Ann-Shyn
  作者单位：National Tsing Hua University; National Tsing Hua University; National Tsing Hua University; China Medical University Taiwan; Kaohsiung Medical University; National Health Research Institutes - Taiwan
  摘要：Survival in animals relies on navigating environments aligned with physiological needs. In Drosophila melanogaster, antennal ionotropic receptors (IRs) sensing humidity changes govern hygrotaxis behavior. This study sheds light on the crucial role of IR8a neurons in the transition from high humidity avoidance to water- seeking behavior when the flies become thirsty. These neurons demonstrate a heightened calcium response toward high humidity stimuli in satiated flies and a reduced response in ...
• Tropical Andean climate variations since the last deglaciation AI翻译
  作者：Zhao, Boyang; Russell, James M.; Blaus, Ansis; Nascimento, Majoi de Novaes; Freeman, Aaron; Bush, Mark B.
  作者单位：Brown University; Florida Institute of Technology; University of Amsterdam
  摘要：Global warming during the Last Glacial Termination was interrupted by millennial- scale cool intervals such as the Younger Dryas and the Antarctic Cold Reversal (ACR). Although these events are well characterized at high latitudes, their impacts at low latitudes are less well known. We present high- resolution temperature and hydroclimate records from the tropical Andes spanning the past similar to 16,800 y using organic geochemical proxies applied to a sediment core from Laguna Llaviucu, Ecua...
• The neural basis of swap errors in working memory AI翻译
  作者：Alleman, Matteo; Panichello, Matthew; Buschman, Timothy J.; Johnston, W. Jeffrey
  作者单位：Columbia University; Stanford University; Princeton University; Princeton University
  摘要：When making decisions in a cluttered world, humans and other animals often have to hold multiple items in memory at once-such as the different items on a shopping list. Psychophysical experiments in humans and other animals have shown remembered stimuli can sometimes become confused, with participants reporting chimeric stimuli composed of features from different stimuli. In particular, subjects will often make swap errors object. While swap errors have been described behaviorally and theoreti...
• Bioinspired iontronic synapse fibers for ultralow- power multiplexing neuromorphic sensorimotor textiles AI翻译
  作者：Chen, Long; Ren, Ming; Zhou, Jianxian; Zhou, Xuhui; Liu, Fan; Di, Jiangtao; Xue, Pan; Li, Chunsheng; Li, Qingwen; Li, Yang; Wei, Lei; Zhang, Qichong
  作者单位：Chinese Academy of Sciences; Suzhou Institute of Nano-Tech & Nano-Bionics, CAS; Nanyang Technological University; Yangzhou University; Suzhou University of Science & Technology; Shandong University
  摘要：Artificial neuromorphic devices can emulate dendric integration, axonal parallel transmission, along with superior energy efficiency in facilitating efficient information processing, offering enormous potential for wearable electronics. However, integrating such circuits into textiles to achieve biomimetic information perception, processing, and control motion feedback remains a formidable challenge. Here, we engineer a quasi- solid- state iontronic synapse fiber (ISF) comprising photoresponsi...
• Controlled pathways and sequential information processing in serially coupled mechanical hysterons (vol 121, e2308414121, 2024) AI翻译
  作者：Korovin, George; Vermaire, Ivo R.; Jin, Lishuai; Bense, Hadrien; van Hecke, Martin
• CMOS- compatible reconstructive spectrometers with self- referencing integrated Fabry-Perot resonators AI翻译
  作者：You, Chunyu; Li, Xing; Hu, Yuhang; Huang, Ningge; Wang, Yang; Wu, Binmin; Jiang, Guobang; Huang, Jiayuan; Zhang, Ziyu; Chen, Bingxin; Wu, Yue; Liu, Junhan; Chen, Xiangzhong; Song, Enming; Cui, Jizhai; Zhou, Peng; Di, Zengfeng; An, Zhenghua; Huang, Gaoshan; Mei, Yongfeng
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS
  摘要：Miniaturized reconstructive spectrometers play a pivotal role in on-chip and portable devices, offering high-resolution spectral measurement through precalibrated spectral responses and AI-driven reconstruction. However, two key challenges persist for practical applications: artificial intervention in algorithm parameters and compatibility with complementary metal-oxide-semiconductor (CMOS) manufacturing. We present a cutting-edge miniaturized reconstructive spectrometer that incorporates a se...
• Isotope and morphometrical evidence reveals the technological package associated with agriculture adoption in western Europe AI翻译
  作者：Araus, Jose L.; Gascon, Mireia; Ros-Sabe, Eva; Pique, Raquel; Rezzouk, Fatima Z.; Aguilera, Monica; Voltas, Jordi; Pena- Chocarro, Leonor; Perez-Jorda, Guillem; Terradas, Xavier; Palomo, Antoni; Ferrio, Juan Pedro; Antolin, Ferran
  作者单位：University of Barcelona; Autonomous University of Barcelona; Universitat de Lleida; Consejo Superior de Investigaciones Cientificas (CSIC); University of Valencia; Consejo Superior de Investigaciones Cientificas (CSIC); Consejo Superior de Investigaciones Cientificas (CSIC); University of Basel
  摘要：This study aimed to reconstruct the environmental conditions and the crop management practices and plant characteristics when agriculture appeared in western Europe. We analyzed oak charcoal and a large number of cereal caryopsides recovered from La Peninsula. The carbon isotope discrimination (013C) values of oak, the dominant forest species in the region, indicates prevalence of a wet climate at the site. Further, we reconstructed crop management conditions, achievable yield, and crop charac...
• Unraveling clonal CD8 T cell expansion and identification of essential factors in γ- herpesvirus- induced lymphomagenesis AI翻译
  作者：Gong, Meijiao; Myster, Francoise; Azouz, Abdulkader; Sanchez, Guillem Sanchez; Li, Shifang; Charloteaux, Benoit; Yang, Bin; Nichols, Jenna; Lefevre, Lucas; Javaux, Justine; Leemans, Sylvain; Nivelles, Olivier; van Campe, Willem; Roels, Stefan; Mostin, Laurent; van den Berg, Thierry; Davison, Andrew J.; Gillet, Laurent; Connelley, Timothy; Vermijlen, David; Goriely, Stanislas; Vanderplasschen, Alain; Dewals, Benjamin G.
  作者单位：University of Liege; Universite Libre de Bruxelles; Universite Libre de Bruxelles; WELBIO; University of Liege; University of Glasgow; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; Sciensano
  摘要：Alcelaphine gammaherpesvirus 1 (AlHV- 1) asymptomatically persists in its natural host, the wildebeest. However, cross- species transmission to cattle results in the induction of an acute and lethal peripheral T cell lymphoma- like disease (PTCL), named malignant catarrhal fever (MCF). Our previous findings demonstrated an essential role for viral genome maintenance in infected CD8+ T lymphocytes but the exact mechanism(s) leading to lymphoproliferation and MCF remained unknown. To decipher ho...
• Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB AI翻译
  作者：Mishra, Saurabh; Welch, Nicole; Singh, Shashi Shekhar; Singh, Khuraijam Dhanachandra; Bellar, Annette; Kumar, Avinash; Deutz, Lars N.; Hanlon, Maxmillian D.; Kant, Sashi; Dastidar, Sumitava; Patel, Hailee; Agrawal, Vandana; Attaway, Amy H.; Musich, Ryan; Stark, George R.; Tedesco, Francesco Saverio; Truskey, George A.; Weiner, I. David; Karnik, Sadashiva S.; Dasarathy, Srinivasan
  作者单位：Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland Clinic Foundation; University of London; University College London; Francis Crick Institute; Duke University; Cleveland Clinic Foundation; Cleveland Clinic Foundation; State University System of Florida; University of Florida
  摘要：Transceptors, solute transporters that facilitate intracellular entry of molecules and also initiate intracellular signaling events, have been primarily studied in lower- order species. Ammonia, a cytotoxic endogenous metabolite, is converted to urea in hepatocytes for urinary excretion in mammals. During hyperammonemia, when hepatic metabolism is impaired, nonureagenic ammonia disposal occurs primarily in skeletal muscle. Increased ammonia uptake in skeletal muscle is mediated by a membrane- ...
• Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice AI翻译
  作者：Zhong, Xue; Moresco, James J.; Sorelle, Jeffrey A.; Song, Ran; Jiang, Yiao; Nguyen, Mylinh T.; Wang, Jianhui; Bu, Chun Hui; Moresco, Eva Marie Y.; Beutler, Bruce; Choi, Jin Huk
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Despite the availability of life- extending treatments for B cell leukemias and lymphomas, many of these cancers remain incurable. Thus, the development of new molecular targets and therapeutics is needed to expand treatment options. To identify new molecular targets, we used a forward genetic screen in mice to identify genes required for development or survival of lymphocytes. Here, we describe Zfp574, essential gene encoding a zinc finger protein necessary for normal and malignant lymphocyte...