2024

最新文章

• Information structure in Makhuwa: Electrophysiological evidence for a universal processing account AI翻译
  作者：Verdonschot, Rinus G.; van der Wal, Jenneke; Lewis, Ashley; Knudsen, Birgit; Wolfsthurn, Sarah von Grebmer zu; Schiller, Niels O.; Hagoort, Peter
  作者单位：Max Planck Society; Leiden University; Leiden University - Excl LUMC; Radboud University Nijmegen; Leiden University; Leiden University Medical Center (LUMC); City University of Hong Kong
  摘要：There is evidence from both behavior and brain activity that the way information is structured, through the use of focus, can up- regulate processing of focused constituents, likely to give prominence to the relevant aspects of the input. This is hypothesized to be universal, regardless of the different ways in which languages encode focus. In order to test this universalist hypothesis, we need to go beyond the more familiar linguistic strategies for marking focus, such as by means of intonati...
• Clustered protocadherin cis- interactions are required for combinatorial cell-cell recognition underlying neuronal self- avoidance AI翻译
  作者：Wiseglass, Gil; Boni, Nadir; Smorodinsky-Atias, Karina; Rubinstein, Rotem
  作者单位：Tel Aviv University; Tel Aviv University
  摘要：In the developing human brain, only 53 stochastically expressed clustered protocadherin (cPcdh) isoforms enable neurites from individual neurons to recognize and self- avoid while simultaneously maintaining contact with neurites from other neurons. Cell assays have demonstrated that self-- recognition occurs only when all cPcdh isoforms perfectly match across the cell boundary, with a single mismatch in the cPcdh expression profile interfering with recognition. It remains unclear, however, how...
• Structural color in the bacterial domain: The ecogenomics of a 2-dimensional optical phenotype AI翻译
  作者：Zomer, Aldert; Ingham, Colin J.; von Meijenfeldt, F. A. Bastiaan; Doncel, alvaro Escobar; van de Kerkhof, Gea T.; Hamidjaja, Raditijo; Schouten, Sanne; Schertel, Lukas; Mueller, Karin H.; Caton, Laura; Hahnke, Richard L.; Bolhuis, Henk; Vignolini, Silvia; Dutilh, Bas E.
  作者单位：Utrecht University; Utrecht University; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); University of Cambridge; University of Fribourg; University of Cambridge; Leibniz Association; Leibniz Institut fur Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); Max Planck Society; Friedrich Schiller University of Jena
  摘要：Structural color is an optical phenomenon resulting from light interacting with nanostructured materials. Although structural color (SC) is widespread in the tree of life, the underlying genetics and genomics are not well understood. Here, we collected and sequenced a set of 87 structurally colored bacterial isolates and 30 related strains lacking SC. Optical analysis of colonies indicated that diverse bacteria from at least two different phyla ( Bacteroidetes and Proteobacteria) ) can create ...
• The MKK3 MAPK cascade integrates temperature and after- ripening signals to modulate seed germination AI翻译
  作者：Otani, Masahiko; Tojo, Ryo; Regnard, Sarah; Zheng, Lipeng; Hoshi, Takumi; Ohmori, Suzuha; Tachibana, Natsuki; Sano, Tomohiro; Koshimizu, Shizuka; Ichimura, Kazuya; Colcombet, Jean; Kawakami, Naoto; Shinozaki, Kazuo
  作者单位：Meiji University; Meiji University; Universite Paris Saclay; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Kagawa University
  摘要：The timing of seed germination is controlled by the combination of internal dormancy and external factors. Temperature is a major environmental factor for seed germination. The permissive temperature range for germination is narrow in dormant seeds and expands during after- ripening (AR) (dormancy release). Quantitative trait loci analyses of preharvest sprouting in cereals have revealed that MKK3, a mitogen- activated protein kinase (MAPK) cascade protein, is a negative regulator of grain dor...
• The value of qualitative data in understanding failure in prediction AI翻译
  作者：Small, Mario L.
  作者单位：Columbia University
• Sharing massive biomedical data at magnitudes lower bandwidth using implicit neural function AI翻译
  作者：Yang, Runzhao; Xiao, Tingxiong; Cheng, Yuxiao; Li, Anan; Qu, Jinyuan; Liang, Rui; Bao, Shengda; Wang, Xiaofeng; Wang, Jue; Suo, Jinli; Luo, Qingming; Dai, Qionghai
  作者单位：Tsinghua University; Tsinghua University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Hainan University
  摘要：Efficient storage and sharing of massive biomedical data would open up their wide accessibility to different institutions and disciplines. However, compressors tailored for natural photos/videos are rapidly limited for biomedical data, while emerging deep learning-based methods demand huge training data and are difficult to generalize. Here, we propose to conduct Biomedical data compRession with Implicit nEural Function (BRIEF) by representing the target data with compact neural networks, whic...
• Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease ( vol 118 , e2111643118 , 2021) AI翻译
  作者：Ahuja, Manuj; Kaidery, Navneet Ammal; Attucks, Otis C.; Mcdade, Erin; Hushpulian, Dmitry M.; Gaisin, Arsen; Gaisina, Irina; Ahn, Young Hoon; Nikulin, Sergey; Poloznikov, Andrey; Gazaryan, Irina; Yamamoto, Masayuki; Matsumoto, Mitsuyo; Igarashi, Kazuhiko; Sharma, Sudarshana M.; Thomas, Bobby
• Unraveling dynamic protein structures by two- dimensional infrared spectra with a pretrained machine learning model AI翻译
  作者：Wu, Fan; Huang, Yan; Yang, Guokun; Ye, Sheng; Mukamel, Shaul; Jiang, Jun
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Anhui University; University of California System; University of California Irvine
  摘要：Dynamic protein structures are crucial for deciphering their diverse biological functions. Two- dimensional infrared (2DIR) spectroscopy stands as an ideal tool for tracing rapid conformational evolutions in proteins. However, linking spectral characteristics to dynamic structures poses a formidable challenge. Here, we present a pretrained machine learning model based on 2DIR spectra analysis. This model has learned signal features from approximately 204,300 spectra to establish a spectrum- st...
• StaufenC facilitates utilization of the ERAD pathway to transport dsRNA through the endoplasmic reticulum to the cytosol AI翻译
  作者：Koo, Jinmo; Palli, Subba Reddy
  作者单位：University of Kentucky; University of California System; University of California Riverside
  摘要：RNA interference (RNAi) is more efficient in coleopteran insects than other insects. StaufenC (StauC), a coleopteran - specific double - stranded RNA (dsRNA) - binding protein, is required for efficient RNAi in coleopterans. We investigated the function of StauC in the intracellular transport of dsRNA into the cytosol, where dsRNA is digested by Dicer enzymes and recruited by Argonauts to RNA - induced silencing complexes. Confocal microscopy and cellular organelle fractionation studies have s...
• The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery AI翻译
  作者：Bienvenu, Arthur; Burette, Melanie; Cantet, Franck; Gourdelier, Manon; Swain, Jitendriya; Cazevieille, Chantal; Clemente, Tatiana; Sadi, Arif; Dupont, Claire; Le Fe, Manon; Bonetto, Nicolas; Bordignon, Benoit; Muriaux, Delphine; Gilk, Stacey; Bonazzi, Matteo; Martinez, Eric
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; University of Nebraska System; University of Nebraska Medical Center; Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS)
  摘要：Intracellular bacterial pathogens divert multiple cellular pathways to establish their niche and persist inside their host. Coxiella burnetii , the causative agent of Q fever, secretes bacterial effector proteins via its Type 4 secretion system to generate a Coxiella - containing vacuole (CCV). Manipulation of lipid and protein trafficking by these effectors is essential for bacterial replication and virulence. Here, we have characterized the lipid composition of CCVs and found that the effect...