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作者：Chen, Ming; Wang, Yekai; Dalal, Roopa; Du, Jianhai; Vollrath, Douglas
作者单位：Stanford University; West Virginia University; West Virginia University; Stanford University
摘要：Loss of mitochondrial electron transport complex (ETC) function in the retinal pigment epithelium (RPE) in vivo results in RPE dedifferentiation and progressive photoreceptor degeneration, and has been implicated in the pathogenesis of age - related macular degeneration. Xenogenic expression of alternative oxidases in mammalian cells and tissues mitigates phenotypes arising from some mitochondrial electron transport defects, but can exacerbate others. We expressed an alternative oxidase from C...
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作者：Costigliola, Lorenzo; Hecksher, Tina; Dyre, Jeppe C.
作者单位：Roskilde University
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作者：Elimelech, Rotem; David, Ofir; Mengual, Carlos De la Cruz; Kalisch, Rotem; Berndt, Wolfgang; Shalyt, Michael; Silberstein, Mark; Hadad, Yaron; Kaminer, Ido
作者单位：Technion Israel Institute of Technology
摘要：In recent decades, a growing number of discoveries in mathematics have been assisted by computer algorithms, primarily for exploring large parameter spaces. As computers become more powerful, an intriguing possibility arises-the interplay between human intuition and computer algorithms can lead to discoveries of mathematical structures that would otherwise remain elusive. Here, we demonstrate computerassisted discovery of a previously unknown mathematical structure, the conservative matrix fie...
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作者：Kiper, Aytug K.; Wegner, Sven; Kadala, Aklesso; Rinne, Susanne; Schuette, Sven; Winter, Zoltan; Bertoune, Mirjam A. R.; Touska, Filip; Matschke, Veronika; Wrobel, Eva; Streit, Anne-Kathrin; Lang, Florian; Schmidt, Constanze; Schulze-Bahr, Eric; Schaefer, Martin K. - H.; Voelkl, Jakob; Seebohm, Guiscard; Zimmermann, Katharina; Decher, Niels
作者单位：Philipps University Marburg; Philipps University Marburg; University of Erlangen Nuremberg; Philipps University Marburg; Ruhr University Bochum; Ruhr University Bochum; Eberhard Karls University of Tubingen; Ruprecht Karls University Heidelberg; University of Munster; Johannes Kepler University Linz
摘要：Low temperatures and cooling agents like menthol induce cold sensation by activating the peripheral cold receptors TRPM8 and TRPA1, cation channels belonging to the TRP channel family, while the reduction of potassium currents provides an additional and/or synergistic mechanism of cold sensation. Despite extensive studies over the past decades to identify the molecular receptors that mediate thermosensation, cold sensation is still not fully understood and many cold- sensitive peripheral neuro...
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作者：Kojima, Mariko; Abe, Satoshi; Furuta, Tadaomi; Hirata, Kunio; Yao, Xinchen; Kobayashi, Ayako; Kobayashi, Ririko; Ueno, Takafumi; Fletterick, Robert
作者单位：Institute of Science Tokyo; Tokyo Institute of Technology; RIKEN; Institute of Science Tokyo; Tokyo Institute of Technology
摘要：Intrinsically disordered proteins (IDPs) play a crucial role in various biological phenomena, dynamically changing their conformations in response to external environmental cues. To gain a deeper understanding of these proteins, it is essential to identify the determinants that fix their structures at the atomic level. Here, we developed a pipeline for rapid crystal structure analysis of IDP using a cell - free protein crystallization (CFPC) method. Through this approach, we successfully demon...
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作者：Telengech, Paul; Hyodo, Kiwamu; Ichikawa, Hiroaki; Kuwata, Ryusei; Kondo, Hideki; Suzuki, Nobuhiro
作者单位：Okayama University; National Agriculture & Food Research Organization - Japan; Okayama University of Science
摘要：It is extremely rare that a single virus crosses host barriers across multiple kingdoms. Based on phylogenetic and paleovirological analyses, it has previously been hypothesized that single members of the family Partitiviridae could cross multiple kingdoms. Partitiviridae accommodates members characterized by their simple bisegmented double - stranded RNA genome; asymptomatic infections of host organisms; the absence of an extracellular route for entry in nature; and collectively broad host ra...
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作者：Sagmeister, Theo; Gubensak, Nina; Buhlheller, Christoph; Grininger, Christoph; Eder, Markus; Dordic, Andela; Millan, Claudia; Medina, Ana; Murcia, Pedro Alejandro Sanchez; Berni, Francesca; Hynonen, Ulla; Vejzovic, Djenana; Damisch, Elisabeth; Kulminskaya, Natalia; Petrowitsch, Lukas; Oberer, Monika; Palva, Airi; Malanovic, Nermina; Codee, Jeroen; Keller, Walter; Uson, Isabel; Pavkov- Keller, Tea
作者单位：University of Graz; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Biologia Molecular de Barcelona (IBMB); Medical University of Graz; Leiden University; Leiden University - Excl LUMC; University of Helsinki; University of Graz; University of Graz; ICREA
摘要：S- layers are crystalline arrays found on bacterial and archaeal cells. Lactobacillus is a diverse family of bacteria known especially for potential gut health benefits. This study focuses on the S- layer proteins from Lactobacillus acidophilus and Lactobacillus amylovorus common in the mammalian gut. Atomic resolution structures of Lactobacillus S- layer proteins SlpA and SlpX exhibit domain swapping, and the obtained assembly model of the main S- layer protein SlpA aligns well with prior ele...
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作者：Thosar, Aniket U.; Cai, Yusheng; Marks, Sean M.; Vicars, Zachariah; Choi, Jeongmoon; Pallath, Akash; Patel, Amish J.
作者单位：University of Pennsylvania
摘要：Antifreeze proteins (AFPs) are remarkable biomolecules that suppress ice formation at trace concentrations. To inhibit ice growth, AFPs must not only bind to ice crystals, but also resist engulfment by ice. The highest supercooling, A T * , for which AFPs are able to resist engulfment is widely believed to scale as the inverse of the separation, L , between bound AFPs, whereas its dependence on the molecular characteristics of the AFP remains poorly understood. By using specialized molecular s...
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作者：Dahlke, Ross; Pan, Jennifer
作者单位：Stanford University
摘要：Social media's pivotal role in catalyzing social movements is widely acknowledged across scientific disciplines. Past research has predominantly explored social media's ability to instigate initial mobilization while leaving the question of its capacity to sustain these movements relatively uncharted. This study investigates the persistence of movement activity on Twitter and Gab following a substantial on -the -ground mobilization event catalyzed by social media-the StoptheSteal movement culm...
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作者：Foushee, Ruthe; Srinivasan, Mahesh
作者单位：The New School; University of California System; University of California Berkeley
摘要：Theories of language development-informed largely by studies of Western, middleclass infants-have highlighted the language that caregivers direct to children as a key driver of language learning. However, some have argued that language development unfolds similarly across environmental contexts, including those in which childdirected language is scarce. This raises the possibility that children are able to learn from other sources of language in their environments, particularly the language di...
