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作者：Carrillo, Judit; Mann, Michael E.; Larson, Christopher J.; Christiansen, Shannon; Willeit, Matteo; Ganopolski, Andrey; Li, Xueke; Murphy, Jack G.
作者单位：University of Pennsylvania; Potsdam Institut fur Klimafolgenforschung
摘要：We find strong path dependence in the evolution of the Plio-Pleistocene glaciations using CLIMBER - 2 Earth System Model simulations from the mid - Pliocene to modern preindustrial (3 My - 0 My BP) driven by a gradual decrease in volcanic carbon dioxide outgassing and regolith removal from basal ice interaction. Path dependence and hysteresis are investigated by alternatively driving the model forward and backward in time. Initiating the model with preindustrial conditions and driving the mode...
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作者：He, Xin-Ling; Zhao, Wenbo; Xie, Yu; Hermann, Andreas; Hemley, Russell J.; Liu, Hanyu; Ma, Yanming
作者单位：Jilin University; Henan Academy of Sciences; Jilin University; University of Edinburgh; University of Edinburgh; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Jilin University
摘要：The recent theory- driven discovery of a class of clathrate hydrides (e.g., CaH6, YH6, YH9, and LaH10) with superconducting critical temperatures (Tc) well above 200 K has opened the prospects for hot superconductivity above room temperature under pressure. Recent efforts focus on the search for superconductors among ternary hydrides that accommodate more diverse material types and configurations compared to binary hydrides. Through extensive computational searches, we report the prediction of...
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作者：Jafari, Maryam; Macho-Gonzalez, Adrian; Diaz, Antonio; Lindenau, Kristen; Fernandez, Olaya Santiago-; Zeng, Mei; Massey, Ashish C.; de Cabo, Rafael; Kaushik, Susmita; Cuervo, Ana Maria
作者单位：Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine
摘要：Chaperone- mediated autophagy (CMA) is part of the mammalian cellular proteostasis network that ensures protein quality control, maintenance of proteome homeostasis, and proteome changes required for the adaptation to stress. Loss of proteostasis is one of the hallmarks of aging. CMA decreases with age in multiple rodent tissues and human cell types. A decrease in lysosomal levels of the lysosome- associated membrane protein type 2A (LAMP2A), the CMA receptor, has been identified as a main rea...
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作者：Vermeij, Geerat J.
作者单位：University of California System; University of California Davis
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作者：Boffi, Nicholas M.; Vanden-Eijnden, Eric
作者单位：New York University
摘要：Active matter systems, from self-propelled colloids to motile bacteria, are characterized by the conversion of free energy into useful work at the microscopic scale. They involve physics beyond the reach of equilibrium statistical mechanics, and a persistent challenge has been to understand the nature of their nonequilibrium states. The entropy production rate and the probability current provide quantitative ways to do so by measuring the breakdown of time -reversal symmetry. Yet, their effici...
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作者：Greenwich, Jennifer L.; Eagan, Justin L.; Feirer, Nathan; Boswinkle, Kaleb; Minasov, George; Shuvalova, Ludmilla; Inniss, Nicole L.; Raghavaiah, Jakka; Ghosh, Arun K.; Satchell, Karla J. F.; Allen, Kylie D.; Fuqua, Clay
作者单位：Indiana University System; Indiana University Bloomington; Virginia Polytechnic Institute & State University; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Purdue University System; Purdue University; Purdue University System; Purdue University
摘要：Biofilm formation and surface attachment in multiple Alphaproteobacteria is driven by unipolar polysaccharide (UPP) adhesins. The pathogen Agrobacterium tumefaciens produces a UPP adhesin, which is regulated by the intracellular second messenger cyclic diguanylate monophosphate (c- di- GMP). Prior studies revealed that DcpA, a diguanylate cyclase- phosphodiesterase, is crucial in control of UPP production and surface attachment. DcpA is regulated by PruR, a protein with distant similarity to e...
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作者：Ravindran, Sandeep
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作者：Backofen, Rainer; Altawil, Abdelrahman Y. A.; Salvalaglio, Marco; Voigt, Axel
作者单位：Technische Universitat Dresden; Technische Universitat Dresden; Technische Universitat Dresden
摘要：We demonstrate that the complex spatiotemporal structure in active fluids can feature characteristics of hyperuniformity. Using a hydrodynamic model, we show that the transition from hyperuniformity to nonhyperuniformity and antihyperuniformity depends on the strength of active forcing and can be related to features of active turbulence without and with scaling characteristics of inertial turbulence. Combined with identified signatures of Levy walks and nonuniversal diffusion in these systems,...
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作者：Fordham, Damien A.; Brown, Stuart C.; Canteri, Elisabetta; Austin, Jeremy J.; Lomolino, Mark, V; Haythorne, Sean; Armstrong, Edward; Bocherens, Herve; Manica, Andrea; Rey-Iglesia, Alba; Rahbek, Carsten; Nogues-Bravo, David; Lorenzen, Eline D.
作者单位：University of Adelaide; University of Copenhagen; University of Copenhagen; University of Copenhagen; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry; University of Melbourne; University of Helsinki; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Eberhard Karls University of Tubingen; University of Cambridge; Peking University; University of Southern Denmark
摘要：The extinction of the woolly rhinoceros ( Coelodonta antiquitatis ) at the onset of the Holocene remains an enigma, with conflicting evidence regarding its cause and spatiotemporal dynamics. This partly reflects challenges in determining demographic responses of late Quaternary megafauna to climatic and anthropogenic causal drivers with available genetic and paleontological techniques. Here, we show that elucidating mechanisms of ancient extinctions can benefit from a detailed understanding of...
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作者：Min, Charles K.; Nwachukwu, Jerome C.; Hou, Yingwei; Russo, Robin J.; Papa, Alexandra; Min, Jian; Peng, Rouming; Kim, Sung Hoon; Ziegler, Yvonne; Rangarajan, Erumbi S.; Izard, Tina; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.; Nettles, Kendall W.
作者单位：Scripps Research Institute; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; State University System of Florida; Florida Atlantic University; Hubei University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：The estrogen receptor -alpha (ER) is thought to function only as a homodimer but responds to a variety of environmental, metazoan, and therapeutic estrogens at subsaturating doses, supporting binding mixtures of ligands as well as dimers that are only partially occupied. Here, we present a series of flexible ER ligands that bind to receptor dimers with individual ligand poses favoring distinct receptor conformations-receptor conformational heterodimers-mimicking the binding of two different li...
