2024

最新文章

• Species- resolved, single- cell respiration rates reveal dominance of sulfate reduction in a deep continental subsurface ecosystem AI翻译
  作者：Lindsay, Melody R.; D'Angelo, Timothy; Munson-McGee, Jacob H.; Saidi-Mehrabad, Alireza; Devlin, Molly; McGonigle, Julia; Goodell, Elizabeth; Herring, Melissa; Lubelczyk, Laura C.; Mascena, Corianna; Brown, Julia M.; Gavelis, Greg; Liu, Jiarui; Yousavich, D. J.; Brehm, Scott D. Hamilton -; Hedlund, Brian P.; Lang, Susan; Treude, Tina; Poulton, Nicole J.; Stepanauskas, Ramunas; Moser, Duane P.; Emerson, David; Orcutt, Beth N.
  作者单位：Bigelow Laboratory for Ocean Sciences; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University System of Ohio; Oberlin College; Northeastern University; University of California System; University of California Los Angeles; Southern Illinois University System; Southern Illinois University; University of South Carolina System; University of South Carolina Columbia; University of California System; University of California Los Angeles
  摘要：Rates of microbial processes are fundamental to understanding the significance of microbial impacts on environmental chemical cycling. However, it is often difficult to quantify rates or to link processes to specific taxa or individual cells, especially in environments where there are few cultured representatives with known physiology. Here, we describe the use of the redox- enzyme- sensitive molecular probe RedoxSensorTM Green to measure rates of anaerobic electron transfer physiology (i.e., ...
• Quantum information scrambling and chemical reactions AI翻译
  作者：Zhang, Chenghao; Kundu, Sohang; Makri, Nancy; Gruebele, Martin; Wolynes, Peter G.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Rice University; Rice University; Rice University
  摘要：The ultimate regularity of quantum mechanics creates a tension with the assumption of classical chaos used in many of our pictures of chemical reaction dynamics. Out- of- time- order correlators (OTOCs) provide a quantum analog to the Lyapunov exponents that characterize classical chaotic motion. Maldacena, Shenker, and Stanford have suggested a fundamental quantum bound for the rate of information scrambling, which resembles a limit suggested by Herzfeld for chemical reaction rates. Here, we ...
• Photo- neuro- immuno- endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system AI翻译
  作者：Slominski, Radomir M.; Chen, Jake Y.; Raman, Chander; Slominski, Andrzej T.
  作者单位：University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; University of Alabama System; University of Alabama Birmingham; US Department of Veterans Affairs; Veterans Health Administration (VHA)
  摘要：we have gathered experimental and obser- vational evidence that UVR spectra of solar radiation have profound effects on systemic body homeostasis, which are defined by their wavelength and energy, nature of chromo- phores and of molecules produced in the barrier organ. Local physicochemical changes induced by solar radiation can lead to activation of local neuro- immuno- endocrine sensing and regulatory mechanisms with their projection to the central or systemic levels. While the precise mecha...
• Sleep deprivation drives brain- wide changes in cholinergic presynapse abundance in Drosophila melanogaster AI翻译
  作者：Weiss, Jacqueline T.; Blundell, Mei Z.; Singh, Prabhjit; Donlea, Jeffrey M.
  作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Davis
  摘要：Sleep is an evolutionarily conserved state that supports brain functions, including synsimilar cell type-specific trends in plasticity occur broadly across the brain, we used a flp- based genetic reporter to label presynaptic BRP in cholinergic, dopaminergic, GABAergic, or glutamatergic neurons. We then collected whole- brain confocal image stacks of BRP intensity to systematically quantify BRP, a marker of presynapse abundance, across 37 neuropil regions of the central fly brain. Our results ...
• Structural transitions modulate the chaperone activities of Grp94 AI翻译
  作者：Amankwah, Yaa S.; Fleifil, Yasmeen; Unruh, Erin; Collins, Preston; Wang, Yi; Vitou, Katherine; Bates, Alison; Obaseki, Ikponwmosa; Sugoor, Meghana; Alao, John Paul; Mccarrick, Robert M.; Gewirth, Daniel T.; Sahu, Indra D.; Li, Zihai; Lorigan, Gary. A.; Kravats, Andrea N.
  作者单位：University System of Ohio; Miami University; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Miami University; Hauptman Woodward Medical Research Institute
  摘要：Hsp90s are ATP- dependent chaperones that collaborate with co- chaperones and Hsp70s to remodel client proteins. Grp94 is the ER Hsp90 homolog essential for folding multiple secretory and membrane proteins. Grp94 interacts with the ER Hsp70, BiP, although the collaboration of the ER chaperones in protein remodeling is not well understood. Grp94 undergoes large - scale conformational changes that are coupled to chaperone activity. Within Grp94, a region called the pre - N domain suppresses ATP ...
• Individual differences in human gaze behavior generalize from faces to objects AI翻译
  作者：Broda, Maximilian Davide; de Haas, Benjamin
  作者单位：Justus Liebig University Giessen
  摘要：Individuals differ in where they fixate on a face, with some looking closer to the eyes while others prefer the mouth region. These individual biases are highly robust, generalize from the lab to the outside world, and have been associated with social cognition and associated disorders. However, it is unclear, whether these biases are specific to faces or influenced by domain- general mechanisms of vision. Here, we juxtaposed these hypotheses by testing whether individual face fixation biases ...
• The effects of mnemonic variability and spacing on memory over multiple timescales AI翻译
  作者：Cowan, Emily T.; Zhang, Yiwen; Rottman, Benjamin M.; Murty, Vishnu P.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：The memory benefit that arises from distributing learning over time rather than in consecutive sessions is one of the most robust effects in cognitive psychology. While prior work has mainly focused on repeated exposures to the same information, in the real world, mnemonic content is dynamic, with some pieces of information staying stable while others vary. Thus, open questions remain about the efficacy of the spacing effect in the face of variability in the mnemonic content. Here, in two expe...
• Collective neural network behavior in a dynamically driven disordered system of superconducting loops AI翻译
  作者：Goteti, Uday S.; Cybart, Shane A.; Dynesa, Robert C.
  作者单位：University of California System; University of California San Diego; University of California System; University of California Riverside
  摘要：Collective properties of complex systems composed of many interacting components such as neurons in our brain can be modeled by artificial networks based on disordered systems. We show that a disordered neural network of superconducting loops with Josephson junctions can exhibit computational properties like categorization and associative memory in the time evolution of its state in response to information from external excitations. Superconducting loops can trap multiples of fluxons in many d...
• The spectrum of heart defects in the TRAF7-related multiple congenital anomalies-intellectual disability syndrome AI翻译
  作者：Pisan, Elise; De Luca, Chiara; Brancati, Francesco; Russo, Rossana Sanchez; Li, Dong; Bhoj, Elizabeth; Wenger, Tara; Marwaha, Ashish; Johnson, Nicole; Beneteau, Claire; Brischoux -Boucher, Elise; Houge, Gunnar; Paulsen, Julie; Hammer, Trine Bjorg; Ek, Jakob; Schweitzer, Daniela; Russell, Bianca E.; Dutra-Clarke, Marina; Nelson, Stanley; Douine, Emilie D.; Corona, Rosario I.; Dudding, Tracy; Thomson, Hannah; Low, Karen; Belnap, Newell; Iascone, Maria; Priolo, Manuela; Carli, Diana; Mussa, Alessandro; Bijlsma, Emilia K.; Kopp, Nathan; Jais, Jean-Philippe; Amiel, Jeanne; Gordona, Christopher T.
  作者单位：Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; University of L'Aquila; Emory University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Washington; University of Washington Seattle; Alberta Childrens Hospital; University of Calgary; University Calgary Hospital; CHU Bordeaux; Universite de Bordeaux; Universite Marie et Louis Pasteur; CHU Besancon; University of Bergen; Haukeland University Hospital; Norwegian University of Science & Technology (NTNU); University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Hunter New England Local Health District; Hunter Genetics; Translational Genomics Research Institute; ASST Papa Giovanni XXIII; Antonio Cardarelli Hospital; University of Turin; A.O.U. Citta della Salute e della Scienza di Torino; University of Turin; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Medical College of Wisconsin; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
• Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids AI翻译
  作者：Bonnet, Valentin; Maikranz, Erik; Madec, Marianne; Vertti-Quintero, Nadia; Cuche, Celine; Mastrogiovanni, Marta; Alcover, Andres; Di Bartolo, Vincenzo; Baroud, Charles N.
  作者单位：Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); Institut Polytechnique de Paris; Ecole Polytechnique; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Geneva; Yeshiva University
  摘要：Evaluating the ability of cytotoxic T lymphocytes (CTLs) to eliminate tumor cells is crucial, for instance, to predict the efficiency of cell therapy in personalized medicine. However, the destruction of a tumor by CTLs involves CTL migration in the extra-tumoral environment, accumulation on the tumor, antigen recognition, and cooperation in killing the cancer cells. Therefore, identifying the limiting steps in this complex process requires spatio-temporal measurements of different cellular ev...