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作者：Diao, Fengqiu; Vasudevan, Deeptha; Heckscher, Ellie S.; White, Benjamin H.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); University of Chicago
摘要：The Trojan exon method, which makes use of intronically inserted T2A - Gal4 cassettes, has been widely used in Drosophila to create thousands of gene - specific Gal4 driver lines. These dual - purpose lines provide genetic access to specific cell types based on their expression of a native gene while simultaneously mutating one allele of the gene to enable loss - of - function analysis in homozygous animals. While this dual use is often an advantage, the truncation mutations produced by Trojan...
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作者：Mclean, Iona R.; Erkelens, Ian M.; Cooper, Emily A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Vision can provide useful cues about the geometric properties of an object, like its size, distance, pose, and shape. But how the brain merges these properties into a complete sensory representation of a three- dimensional object is poorly understood. To address this gap, we investigated a visual illusion in which humans misperceive the shape of an object due to a small change in one eye's retinal image. We first show that this illusion affects percepts of a highly familiar object under comple...
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作者：Singh, Pradeep Kumar; Pires, Elisa Nicoloso Simoes-; Chen, Zu- Lin; Torrente, Daniel; Calvano, Marissa; Sharma, Anurag; Strickland, Sidney; Norris, Erin H.
作者单位：Rockefeller University; Rockefeller University
摘要：Proteinaceous brain inclusions, neuroinflammation, and vascular dysfunction are common pathologies in Alzheimer's disease (AD). Vascular deficits include a compromised blood-brain barrier, which can lead to extravasation of blood proteins like fibrinogen into the brain. Fibrinogen's interaction with the amyloid-beta (A beta) peptide is known to worsen thrombotic and cerebrovascular pathways in AD. Lecanemab, an FDA-approved antibody therapy for AD, clears A beta plaque from the brain and slows...
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作者：Thomas, Mekha A.; Naik, Pooja; Wang, Hong; Giles, Jon T.; Girgis, Alexander A.; Kim, Seok - Young; Johnson, Tory P.; Curran, Ashley M.; Crawford, Jonathan D.; Jahanbani, Shaghayegh; Bingham, Clifton O.; Robinson, William H.; Na, Chan Hyun; Darrah, Erika
作者单位：Johns Hopkins University; Columbia University; Johns Hopkins University; Johns Hopkins University; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Stanford University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System
摘要：Although anti- citrullinated protein autoantibodies (ACPAs) are a hallmark serological feature of rheumatoid arthritis (RA), the mechanisms and cellular sources behind the generation of the RA citrullinome remain incompletely defined. Peptidylarginine deiminase IV (PAD4), one of the key enzymatic drivers of citrullination in the RA joint, is expressed by granulocytes and monocytes; however, the subcellular localization and contribution of monocyte- derived PAD4 to the generation of citrullinat...
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作者：Ben David, Saar; Ho, Kevin Y. L.; Tanentzapf, Guy; Zaritsky, Assaf
作者单位：Ben-Gurion University of the Negev; University of British Columbia
摘要：Tissue development occurs through a complex interplay between many individual cells. Yet, the fundamental question of how collective tissue behavior emerges from heterogeneous and noisy information processing and transfer at the single - cell level remains unknown. Here, we reveal that tissue scale signaling regulation can arise from local gap- junction mediated cell-cell signaling through the spatiotemporal establishment of an intermediate - scale of transient multicellular communication comm...
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作者：Maroui, Mohamed Ali; Odongo, Grace Akinyi; Mundo, Lucia; Manara, Francesca; Mure, Fabrice; Fusil, Floriane; Jay, Antonin; Gheit, Tarik; Michailidis, Thanos M.; Ferrara, Domenico; Leoncini, Lorenzo; Murray, Paul; Manet, Evelyne; Ohlmann, Theophile; De Boevre, Marthe; De Saeger, Sarah; Cosset, Francois-Loic; Lazzi, Stefano; Accardi, Rosita; Herceg, Zdenko; Gruffat, Henri; Khoueiry, Rita
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; World Health Organization; International Agency for Research on Cancer (IARC); University of Limerick; University of Limerick; University of Siena; Ghent University; University of Johannesburg
摘要：Epstein-Barr Virus (EBV) infects more than 90% of the adult population worldwide. EBV infection is associated with Burkitt lymphoma (BL) though alone is not sufficient to induce carcinogenesis implying the involvement of co- factors. BL is endemic in African regions faced with mycotoxins exposure. Exposure to mycotoxins and oncogenic viruses has been shown to increase cancer risks partly through the deregulation of the immune response. A recent transcriptome profiling of B cells exposed to afl...
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作者：Serwanja, Jamil; Wieland, Alexander C.; Haubenhofer, Astrid; Brandstetter, Hans; Schoenauer, Esther
作者单位：Salzburg University; Salzburg University
摘要：Bacterial collagenases are important virulence factors, secreted by several pathogenic Clostridium, Bacillus, Spirochaetes, and Vibrio species. Yet, the mechanism by which these enzymes cleave collagen is not well understood. Based on biochemical and mutational studies we reveal that collagenase G (ColG) from Hathewaya histolytica recognizes and processes collagen substrates differently depending on their nature (fibrillar vs. soluble collagen); distinct dynamic interactions between the activa...
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作者：Zhang, Lin; Cavallini, Martina; Wang, Junqiang; Xin, Ruiqi; Zhang, Qiangge; Feng, Guoping; Sanes, Joshua R.; Peng, Yi - Rong
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University
摘要：In primates, high- acuity vision is mediated by the fovea, a small specialized central region of the retina. The fovea, unique to the anthropoid lineage among mammals, undergoes notable neuronal morphological changes during postnatal maturation. However, the extent of cellular similarity across anthropoid foveas and the molecular underpinnings of foveal maturation remain unclear. Here, we used high- throughput single-cell RNA sequencing to profile retinal cells of the common marmoset (Callithr...
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作者：Ahmed, Rafi
作者单位：Emory University
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作者：Brannon, Tiffany N.
作者单位：University of California System; University of California Los Angeles
摘要：Racism is associated with negative intergenerational (infant) outcomes. That is, racism, both perceived and structural, is linked to critical, immediate, and long- term health factors such as low birth weight and infant mortality. Antiracism-resistance to racism such as support for the Black Lives Matter (BLM) movement-has been linked to positive emotional, subjective, and mental health outcomes among adults and adolescents. To theoretically build on and integrate such past findings, the prese...
