2024

最新文章

• Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life AI翻译
  作者：Hartig, Elli I.; Day, Matthew; Jarysta, Amandine; Tarchini, Basile
  作者单位：Tufts University; Jackson Laboratory
  摘要：The hair bundle, or stereocilia bundle, is the mechanosensory compartment of hair cells (HCs) in the inner ear. To date, most mechanistic studies have focused on stereocilia bundle morphogenesis, and it remains unclear how this organelle critical for hearing preserves its precise dimensions during life in mammals. The GPSM2-GNAI complex occupies the distal tip of stereocilia in the tallest row and is required for their elongation during development. Here, we ablate GPSM2-GNAI in adult mouse HC...
• Accurate prediction of discontinuous crack paths in random porous media via a generative deep learning model AI翻译
  作者：He, Yuxiang; Tan, Yu; Yang, Mingshan; Wang, Yongbin; Xu, Yangguang; Yuan, Jianghong; Li, Xiangyu; Chen, Weiqiu; Kang, Guozheng
  作者单位：Southwest Jiaotong University; Chengdu University of Technology; Zhejiang University
  摘要：Pore structures provide extra freedoms for the design of porous media, leading to desirable properties, such as high catalytic rate, energy storage efficiency, and specific strength. This unfortunately makes the porous media susceptible to failure. Deep understanding of the failure mechanism in microstructures is a key to customizing high- performance crack- resistant porous media. However, solving the fracture problem of the porous materials is computationally intractable due to the highly co...
• Alveolar macrophage function is impaired following inhalation of berry e- cigarette vapor AI翻译
  作者：Kulle, Amelia; Li, Ziyi; Kwak, Ashley; Mancini, Mathieu; Young, Daniel; Avizonis, Daina Zofija; Groleau, Marc; Baglole, Carolyn J.; Behr, Marcel A.; King, Irah L.; Divangahi, Maziar; Langlais, David; Wang, Jing; Blagih, Julianna; Penz, Erika; Dufour, Antoine; Thanabalasuriar, Ajitha
  作者单位：McGill University; McGill University; University of Calgary; McGill University; McGill University; McGill University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Universite de Montreal; University of Saskatchewan
  摘要：In the lower respiratory tract, the alveolar spaces are divided from the bloodstream and the external environment by only a few microns of interstitial tissue. Alveolar macrophages (AMs) defend this delicate mucosal surface from invading infections by regularly patrolling the site. AMs have three behavior modalities to achieve this goal: extending cell protrusions to probe and sample surrounding areas, squeezing the whole cell body between alveoli, and patrolling by moving the cell body around...
• miR-96-5p expression is sufficient to induce and maintain the senescent cell fate in the absence of stress AI翻译
  作者：Santiago, Fernando E.; Adige, Tanvi; Mahmud, Shamsed; Dong, Xiao; Niedernhofer, Laura J.; Robbins, Paul D.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Senescence is a cell fate driven by different types of stress that results in exit from the cell cycle and expression of an inflammatory senescence- associated secretory phenotype (SASP). Here, we demonstrate that stable overexpression of miR-96-5p was sufficient to induce cellular senescence in the absence of genotoxic stress, inducing expression of certain markers of early senescence including SASP factors while repressing markers of deep senescence including LINE- 1 and type 1 interferons. ...
• Phosphorescent metallaknots of Au(I)- bis(acetylide) strands directed by Cu(I) π- coordination AI翻译
  作者：Huang, Ya - Zi; Yang, Raorao; Zhang, Liang; Chen, Zhong - Ning
  作者单位：Chinese Academy of Sciences; Fujian Institute of Research on the Structure of Matter, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; East China Normal University
  摘要：Knots containing metal atoms as part of their continuous strand backbone are termed as metallaknots. While several metallaknots have been synthesized through one- pot self- assembly, the designed synthesis of metallaknots by controlling the arrangement of entanglements and strands connectivity remains unexplored. Here, we report the synthesis of metallaknots composed with Au(I)- bis(acetylide) linkages and templated by Cu(I) ions. Varying the ratio of the building blocks results in the switcha...
• Mechanical confinement prevents ectopic platelet release AI翻译
  作者：Guinard, Ines; Brassard-Jollive, Noemie; Ruch, Laurie; Weber, Josiane; Eckly, Anita; Boscher, Julie; Leon, Catherine
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universite de Lorraine
  摘要：Blood platelets are produced by megakaryocytes (MKs), their parent cells, which are in the bone marrow. Once mature, MK pierces through the sinusoid vessel, and the initial protrusion further elongates as proplatelet or buds to release platelets. The mechanisms controlling the decision to initiate proplatelet and platelet formation are unknown. Here, we show that the mechanical properties of the microenvironment prevent proplatelet and platelet release in the marrow stroma while allowing this ...
• Contradiction: Inhibiting inflammation and immunosuppression in the treatment of IBD AI翻译
  作者：Cao, Wenfu; Xiong, Yongjian; Chen, Dapeng
  作者单位：Dalian Medical University; Dalian Medical University
• Breaking the activity-selectivity trade- off of CO2 hydrogenation to light olefins AI翻译
  作者：Wang, Xiaoyue; Zeng, Ting; Guo, Xiaohong; Yan, Zhiqiang; Ban, Hongyan; Yao, Ruwei; Li, Congming; Gu, Xiang-Kui; Ding, Mingyue
  作者单位：Taiyuan University of Technology; Wuhan University; Wuhan University
  摘要：Catalytic hydrogenation of CO2 to value- added fuels and chemicals is of great importance to carbon neutrality but suffers from an activity-selectivity trade- off, leading to limited catalytic performance. Herein, the ZnFeAlO4 + SAPO-34 composite catalyst was designed, which can simultaneously achieve a CO2 conversion of 42%, a CO selectivity of 50%, and a C2-C4= selectivity of 83%, resulting in a C2-C4= yield of almost 18%. This superior catalytic performance was found to be from the presence...
• Observational evidence for groundwater influence on crop yields in the United States AI翻译
  作者：Deines, Jillian M.; Archontoulis, Sotirios, V; Huber, Isaiah; Lobell, David B.
  作者单位：Stanford University; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Iowa State University
  摘要：As climate change shifts crop exposure to dry and wet extremes, a better understanding of factors governing crop response is needed. Recent studies identified shallow groundwater-groundwater within or near the crop rooting zone-as influential, yet existing evidence is largely based on theoretical crop model simulations, indirect or static groundwater data, or small- scale field studies. Here, we use observational satellite yield data and dynamic water table simulations from 1999 to 2018 to pro...
• Breaking the size limitation of nonadiabatic molecular dynamics in condensed matter systems with local descriptor machine learning AI翻译
  作者：Liu, Dongyu; Wang, Bipeng; Wu, Yifan; Vasenko, Andrey S.; Prezhdo, Oleg, V
  作者单位：HSE University (National Research University Higher School of Economics); University of Southern California; University of Southern California; University of Southern California; University of Southern California
  摘要：Nonadiabatic molecular dynamics (NA- MD) is a powerful tool to model far- from- equilibrium processes, such as photochemical reactions and charge transport. NA- MD application to condensed phase has drawn tremendous attention recently for development of next- generation energy and optoelectronic materials. Studies of condensed matter allow one to employ efficient computational tools, such as density functional theory (DFT) and classical path approximation (CPA). Still, system size and simulati...