2024

最新文章

• Identification of highly selective SIK 1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation AI翻译
  作者：Babbe, Holger; Sundberg, Thomas B.; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T.; Mak, Puiying A.; Mathur, Ashok; Mercado-Marin, Eduardo, V; Metkar, Shailesh; Raymond, Donald D.; Rives, Marie -Laure; Rizzolio, Michele; Shaffer, Paul L.; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P.; Wei, Jianmei; Desai, Prerak T.; Ong, Luvena L.; Koudriakova, Tatiana; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar K.; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B.; Plevy, Scott; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.
  作者单位：Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：The salt- inducible kinases (SIK) 1-3 are key regulators of pro- versus anti- inflammatory cytokine responses during innate immune activation. The lack of highly SIK- family or SIK isoform- selective inhibitors suitable for repeat, oral dosing has limited the study of the optimal SIK isoform selectivity profile for suppressing inflammation in vivo. To overcome this challenge, we devised a structure-based design strategy for developing potent SIK inhibitors that are highly selective against oth...
• How cognitive selection affects language change AI翻译
  作者：Li, Ying; Breithaupt, Fritz; Hills, Thomas; Lin, Ziyong; Chen, Yanyan; Siew, Cynthia S. W.; Hertwig, Ralph
  作者单位：Chinese Academy of Sciences; Institute of Psychology, CAS; Max Planck Society; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Warwick; Max Planck Society; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; National University of Singapore
  摘要：Like biological species, words in language must compete to survive. Previously, it has been shown that language changes in response to cognitive constraints and over time becomes more learnable. Here, we use two complementary research paradigms to demonstrate how the survival of existing word forms can be predicted by psycholinguistic properties that impact language production. In the first study, we analyzed the survival of words in the context of interpersonal communication. We analyzed data...
• The elusive nature of Martian liquid brines AI翻译
  作者：Chevrier, Vincent F.; Slank, Rachel A.
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; Universities Space Research Association (USRA)
  摘要：The possible presence of brines on Mars adds an intriguing dimension to the exploration of Martian environments. Their potential involvement in the formation of recurring slope lineae has sparked debates on the existence of liquid water versus alternative dry processes. In situ instrumentation on rovers and landers has been instrumental in providing valuable data for comprehending the dynamics of brines. Laboratory experiments and thermodynamic simulations conducted under Martian conditions of...
• The benefits of removing toxic chemicals from plastics AI翻译
  作者：Cropper, Maureen; Dunlop, Sarah; Hinshaw, Hudson; Landrigan, Philip; Park, Yongjoon; Symeonides, Christos
  作者单位：University System of Maryland; University of Maryland College Park; Resources for the Future; Minderoo Foundation; University of Western Australia; Boston College; University of Massachusetts System; University of Massachusetts Amherst; Royal Children's Hospital Melbourne
  摘要：More than 16,000 chemicals are incorporated into plastics to impart properties such as color, flexibility, and durability.These chemicals may leach from plastics, resulting in widespread human exposure during everyday use. Two plastic- associated chemicals- bisphenol A (BPA) and di(2- ethylhexyl) phthalate (DEHP)-and a class of chemicals-brominated flame retardants [polybrominated diphenyl ethers (PBDEs)]-are credibly linked to adverse health and cognitive impacts. BPA exposures are associated...
• Stimulus-invariant aspects of the retinal code drive discriminability of natural scenes AI翻译
  作者：Hoshal, Benjamin D.; Holmes, Caroline M.; Bojanek, Kyle; Salisbury, Jared M.; Berry II, Michael J.; Marre, Olivier; Palmer, Stephanie E.
  作者单位：Harvard University; University of Chicago; Princeton University; University of Chicago; University of Chicago; Princeton University; Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Princeton University
  摘要：Everything that the brain sees must first be encoded by the retina, which maintains a reliable representation of the visual world in many different, complex natural scenes while also adapting to stimulus changes. This study quantifies whether and how the brain selectively encodes stimulus features about scene identity in complex naturalistic environments. While a wealth of previous work has dug into the static and dynamic features of the population code in retinal ganglion cells (RGCs), less i...
• Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+T cell response AI翻译
  作者：Wang, Heng; Xu, Fang; Yao, Chenlu; Dai, Huaxing; Xu, Jialu; Wu, Bingbing; Tian, Bo; Shi, Xiaolin; Wang, Chao
  作者单位：Soochow University - China; Soochow University - China; Soochow University - China
  摘要：Inhibiting indoleamine 2,3 dioxygenase (IDO) for anticancer therapy has garnered significant attention in recent years. However, current IDO inhibitors face significant challenges which limit their clinical application. Here, we genetically engineered a high tryptophan- expressing Clostridium butyricum (L- Trp CB) strain that can colonize tumors strictly following systemic administration. We revealed that butyrate produced by L- Trp CB can inhibit IDO activity, preventing tryptophan catabolism...
• Cyanobacteria-probiotics symbionts for modulation of intestinal inflammation and microbiome dysregulation in colitis AI翻译
  作者：Yang, Jiali; Tan, Shaochong; Ge, Shengchan; Yang, Mingzhu; Liu, Hua; Liu, Wei; Zhang, Kaixiang; Zhang, Zhenzhong; Wang, Zhi-Hao; Shi, Jinjin; Liu, Junjie
  作者单位：Zhengzhou University; Qingdao University
  摘要：Inflammatory bowel disease (IBD) is often associated with excessive inflammatory response and highly dysregulated gut microbiota. Traditional treatments utilize drugs to manage inflammation, potentially with probiotic therapy as an adjuvant. However, current standard practices often suffer from detrimental side effects, low bioavailability, and unsatisfactory therapeutic outcomes. Microbial complexes characterized by mutually beneficial symbiosis hold great promise for IBD therapy. Here, we ag...
• Modeling the within-host dynamics of Plasmodium vivax hypnozoite activation: An analysis of the SPf66 vaccine trial AI翻译
  作者：Mehra, Somya; Nosten, Francois; Luxemburger, Christine; White, Nicholas J.; Watson, James A.
  作者单位：Mahidol University; Mahidol Oxford Tropical Medicine Research Unit (MORU); University of Melbourne; Mahidol University; University of Oxford
  摘要：Plasmodium vivax parasites can lie dormant in the liver as hypnozoites, activating weeks to months after sporozoite inoculation to cause relapsing malarial illness. It is not known what biological processes govern hypnozoite activation. We use longitudinal data from the most detailed cohort study ever conducted in an area where both Plasmodium falciparum and P. vivax were endemic to fit a simple within-host mathematical model of P. vivax hypnozoite activation. 1,344 children living on the Thai...
• Understanding paralogous epilepsy-associated GABAA receptor variants: Clinical implications, mechanisms, and potential pitfalls AI翻译
  作者：Kan, Anthony S. H.; Kusay, Ali S.; Mohammadi, Nazanin A.; Lin, Susan X. N.; Liao, Vivian W. Y.; Lesca, Gaetan; Souci, Sabrine; Milh, Mathieu; Christophersen, Palle; Chebib, Mary; Moller, Rikke S.; Absalom, Nathan L.; Jensen, Anders A.; Ahring, Philip K.
  作者单位：University of Sydney; Linkoping University; University of Southern Denmark; CHU Lyon; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Claude Bernard Lyon 1; CHU Lyon; Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Western Sydney University; University of Copenhagen
  摘要：Recent discoveries have revealed that genetic variants in gamma- aminobutyric acid type A (GABAA) receptor subunits can lead to both gain- of- function (GOF) and loss- of- function (LOF) receptors. GABAA receptors, however, have a pseudosymmetrical pentameric assembly, and curiously diverse functional outcomes have been reported for certain homologous variants in paralogous genes (paralogous variants). To investigate this, we assembled a cohort of 11 individuals harboring paralogous M1 proline...
• Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis AI翻译
  作者：Nguyen, Hung N.; Jeong, Yunju; Kim, Yunhye; Kamiya, Mari; Kim, Yaunghyun; Athar, Humra; Castaldi, Peter J.; Hersh, Craig P.; Menon, Jaivardhan A.; Wong, Jessie; Chan, Ian; Oldham, William M.; Padera, Robert F.; Sharma, Nirmal S.; Sholl, Lynette M.; Vivero, Marina; Watts, Gerald F. M.; Knipe, Rachel S.; Black, Katharine E.; Hariri, Lida P.; Yun, Jeong H.; Merriam, Louis T.; Yuan, Ke; Kim, Edy Y.; Brenner, Michael B.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Kyung Hee University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
  摘要：Fibrosis drives end- organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGF(3, have largely failed. Here, we target the leukemia inhibitory factor receptor (LIFR) as an autocrine master amplifier of multiple upstream activators of lung fibroblasts. In idiopathic pulmonary fibrosis (IPF), the most common fibrotic lung disease, we found that lung myofibroblasts had high LIF expression, and the fibroblasts in fibroblastic foci ...