2024

最新文章

• Reply to Araújo: Good science requires focus AI翻译
  作者：Sethi, Sarab S.; Bick, Avery; Chen, Ming-Yuan; Crouzeilles, Renato; Hillier, Ben V.; Lawson, Jenna; Lee, Chia-Yun; Liu, Shih-Hao; Parruco, Celso Henrique de Freitas; Rosten, Carolyn M.; Somveille, Marius; Tuanmu, Mao-Ning; Banks-Leite, Cristina
  作者单位：Imperial College London; Norwegian Institute Nature Research; National Taiwan University; University of London; University College London; Academia Sinica - Taiwan
• Beyond genomics in Patescibacteria: A trove of unexplored biology packed into ultrasmall bacteria AI翻译
  作者：Srinivas, Pooja; Peterson, S. Brook; Gallagher, Larry A.; Wang, Yaxi; Mougous, Joseph D.
  作者单位：University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Patescibacteria, also known as the Candidate Phyla Radiation, are a diverse clade of largely uncultivated, small bacteria that comprise a significant proportion of all bacterial diversity. The few members that have been cultivated exhibit a fascinating life cycle in which they grow as obligate epibionts on the surface of host bacteria. In this Perspective, we make the case that the study of these unique, divergent, and poorly characterized organisms represents an exciting frontier in microbiol...
• How to make land use policy decisions: Integrating science and economics to deliver connected climate, biodiversity, and food objectives AI翻译
  作者：Bateman, Ian J.; Binner, Amy; Addicott, Ethan T.; Balmford, Ben; Cho, Frankie H. T.; Daily, Gretchen C.; De-Gol, Anthony; Eisenbarth, Sabrina; Faccioli, Michela; Ferguson-Gow, Henry; Ferrini, Silvia; Fezzi, Carlo; Gannon, Kate; Groom, Ben; Harper, Anna B.; Harwood, Amii; Hillier, Jon; Hulme, Mark F.; Lee, Christopher F.; Liuzzo, Lorena; Lovett, Andrew; Mancini, Mattia C.; Matthews, Robert; Morison, James I. L.; Owen, Nathan; Pearson, Richard G.; Polasky, Stephen; Siriwardena, Gavin; Smith, Pete; Snowdon, Pat Pat; Tippett, Peter; Vetter, Sylvia H.; Vinjili, Shailaja; Vossler, Christian A.; Watson, Robert T.; Williamson, Daniel; Day, Brett H.
  作者单位：University of Exeter; Stanford University; University of East Anglia; University of St Gallen; University of Trento; University of London; University College London; University of Trento; University of London; London School Economics & Political Science; University System of Georgia; University of Georgia; University of Edinburgh; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; British Trust for Ornithology; University of Minnesota System; University of Minnesota Twin Cities; University of Aberdeen; University of Exeter; University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville
  摘要：Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek et al., Science 376, 1416-1421 (2022)]. The interconnected and spatially varying nature of the impacts of land use change means that these challenges must be addressed simultaneously [H.- O. P & ouml;rtner et al., Science 380, eabl4881 (2023)]. However, governments commonly focus on single issues, incentivizing land use change via Flat- Rate subsidies...
• PBLD enhances antiviral innate immunity by promoting the p53-USP4-MAVS signaling axis AI翻译
  作者：Chu, Fengyun; Hou, Peili; Zhu, Hongchao; Gao, Yan; Wang, Xiaomeng; He, Wenqi; Ren, Juan; Li, Min; Liu, Yu; He, Daniel Chang; Wang, Hongmei; Gao, Yuwei; He, Hongbin
  作者单位：Shandong Normal University; Shandong Agricultural University; Jilin University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Chinese Academy of Agricultural Sciences
  摘要：Phenazine biosynthesis- like domain- containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that the activity of PBLD extends to other PRRs, we focused on the RLR pathway activated via the p53-USP4-MAVS axis in response to virus infections. We found that PBLD deubiquitinates and stabilizes MAVS through ubiquitin- specific proteas...
• L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins (vol 117, pg 17369, 2020) AI翻译
  作者：Johnson, Martin T.; Gudlur, Aparna; Zhang, Xuexin; Xin, Ping; Emrich, Scott M.; Yoast, Ryan E.; Courjaret, Raphael; Nwokonko, Robert M.; Li, Wei; Hempel, Nadine; Machaca, Khaled; Gill, Donald L.; Hogan, Patrick G.; Trebak, Mohamed
• Global trends in antibiotic consumption during 2016-2023 and future projections through 2030 AI翻译
  作者：Klein, Eili Y.; Impalli, Isabella; Poleon, Suprena; Denoel, Philippe; Cipriano, Mariateresa; Boeckel, Thomas P. Van; Pecetta, Simone; Bloom, David E.; Nandi, Arindam
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; GlaxoSmithKline; GlaxoSmithKline; University of Zurich; Universite Libre de Bruxelles; Harvard University; Harvard T.H. Chan School of Public Health; Population Council
  摘要：Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant among them. Analyzing trends and patterns in consumption can aid in developing policies to mitigate the burden of antimicrobial resistance and global disparities in access to antibiotics. Using pharmaceutical sales data licensed from IQVIA, we estimate national- level trends in antibiotic consumption in 67 countries during 2016-2023 and analyze the ...
• Cognitive reflection is a distinct and measurable trait AI翻译
  作者：Meyer, Andrew; Attali, Yigal; Bar-Hillel, Maya; Frederick, Shane; Kahneman, Daniel
  作者单位：Chinese University of Hong Kong; Hebrew University of Jerusalem; Yale University; Princeton University
  摘要：We report the findings of an adversarial collaboration examining whether the cognitive reflection test (CRT) measures anything beyond mathematical aptitude and, if so, whether its incremental predictive validity can be attributed to reflection, per se. We found that an 8-item CRT has greater predictive validity than an 8-item Mathematical Aptitude Test (MAT) consisting of comparably difficult items which lack dominant intuitive lures. Further, the incremental predictive validity stems from the...
• Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member AI翻译
  作者：Padhi, Chandrashekhar; Field, Christopher M.; Forneris, Clarissa C.; Olszewski, Dominik; Fraley, Amy E.; Sandu, Ioana; Scott, Thomas A.; Farnung, Jakob; Ruscheweyh, Hans - Joachim; Panda, Ananta Narayan; Oxenius, Annette; Greber, Urs F.; Bode, Jeffrey W.; Sunagawa, Shinichi; Raina, Vishakha; Suar, Mrutyunjay; Piel, Joern
  作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Kalinga Institute of Industrial Technology (KIIT)
  摘要：In contrast to the large body of work on bioactive natural products from individually cultivated bacteria, the chemistry of environmental microbial communities remains largely elusive. Here, we present a comprehensive bioinformatic and functional study on a complex and interaction-rich ecosystem, algal-bacterial (microbial) mats of Lake Chilika in India, Asia's largest brackish water body. We report the bacterial compositional dynamics over the mat life cycle, >1,300 reconstructed environmenta...
• PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity AI翻译
  作者：Varuzhanyan, Grigor; Chen, Chia-Chun; Freeland, Jack; He, Tian; Tran, Wendy; Song, Kai; Wang, Liang; Cheng, Donghui; Xu, Shili; Dibernardo, Gabriella A.; Esedebe, Favour N.; Bhatia, Vipul; Han, Mingqi; Abt, Evan R.; Park, Jung Wook; Memarzadeh, Sanaz; Shackelford, David B.; Lee, John K.; Graeber, Thomas G.; Shirihai, Orian S.; Witte, Owen N.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; Fred Hutchinson Cancer Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Duke University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Greater Los Angeles Healthcare System; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Ben-Gurion University of the Negev; University of California System; University of California Los Angeles
  摘要：Adenocarcinomas from multiple tissues can converge to treatment- resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC) progression. Extensive bioinformatics analyses encompassing thousands of patient tumors and human cancer cell lines uncovered enhanced expression of proliferator- activatedreceptor gamma coactivator 1- alpha (PGC-1 alpha), a potent regulator of mitochond...
• Structure- based design of glycoprotein subunit vaccines for mumps AI翻译
  作者：Loomis, Rebecca J.; Lai, Yen-Ting; Sowers, Sun B.; Fisher, Brian; Derrien-Colemyn, Alexandrine; Ambrozak, David R.; Tsybovsky, Yaroslav; Crooke, Stephen N.; Latner, Donald R.; Kong, Wing-Pui; Ruckwardt, Tracy J.; Plotkin, Stanley A.; Kwong, Peter D.; Mascola, John R.; Graham, Barney S.; Hickman, Carole J.; Stewart-Jones, Guillaume B. E.
  作者单位：National Institutes of Health (NIH) - USA; Centers for Disease Control & Prevention - USA; CDC National Center for Immunization & Respiratory Diseases (NCIRD); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Pennsylvania
  摘要：Mumps virus (MuV) is a highly contagious paramyxovirus that is endemic in most regions of the world and continues to cause outbreaks even in highly immunized populations. Outbreaks of mumps in countries with high measles, mumps, and rubella vaccination coverage have been attributed to waning immunity and antigenic differences between the Jeryl Lynn vaccine strain (genotype A) and circulating wild- type viruses. To obtain a subunit vaccine, we used structure- based design to engineer the mumps ...