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作者：Gavryushkin, Pavel N.; Recnik, Aleksander; Donskikh, Katerina G.; V. Banaev, Maksim; Sagatov, Nursultan E.; Rashchenko, Sergey; Volkov, Sergey; Aksenov, Sergey; Mikhailenko, Denis; Korsakov, Andrey; Daneu, Nina; Litasov, Konstantin D.
作者单位：Russian Academy of Sciences; Siberian Branch of the Russian Academy of Sciences; Sobolev Institute of Geology & Mineralogy of the Russian Academy of Sciences; Novosibirsk State University; Slovenian Academy of Sciences & Arts (SASA); Jozef Stefan Institute; Russian Academy of Sciences; Kola Science Centre of the Russian Academy of Sciences; Russian Academy of Sciences; Slovenian Academy of Sciences & Arts (SASA); Jozef Stefan Institute; Vereshchagin Institute of High Pressure Physics, Russian Academy of Sciences; Russian Academy of Sciences
摘要：It is generally accepted that aragonite crystals of biogenic origin are characterized by significantly higher twin densities compared to samples formed during geological processes. Based on our single crystal X-ray diffraction (SCXRD) and transmission electron microscopy (TEM) study of aragonite crystals from various localities, we show that in geological aragonites, the twin densities are comparable to those of the samples from crossed lamellar zones of molluscs shells. The high twin density ...
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作者：Yan, Yan; Luo, Haofei; Qin, Yuwei; Yan, Tingting; Jia, Jinbu; Hou, Yifeng; Liu, Zhijian; Zhai, Jixian; Long, Yanping; Deng, Xian; Cao, Xiaofeng
作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Southern University of Science & Technology; Hainan Academy of Agricultural Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Light plays a central role in plant growth and development, providing an energy source and governing various aspects of plant morphology. Previous study showed that many polyadenylated full- length RNA molecules within the nucleus contain unspliced introns (post- transcriptionally spliced introns, PTS introns), which may play a role in rapidly responding to changes in environmental signals. However, the mechanism underlying post- transcriptional regulation during initial light exposure of youn...
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作者：Zhang, Taiyan; Jiang, Jingjing; Sun, Wenming; Gong, Shuyan; Liu, Xiangwen; Tian, Yang; Wang, Dingsheng
作者单位：Capital Normal University; Beijing Academy of Science & Technology; Tsinghua University
摘要：Oxygen evolution reaction (OER) is the pivotal obstacle of water splitting for hydrogen production. Dual - sites catalysts (DSCs) are considered exceeding single - site catalysts due to the preternatural synergetic effects of two metals in OER. However, appointing the specific spatial configuration of dual - sites toward more efficient catalysis still remains a challenge. Herein, we constructed two configurations of Fe-Co dual- sites: stereo Fe-Co sites (stereo - Fe - Co DSC) and planar Fe-Co ...
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作者：Ahmed, A. Razzaque; Kalesinskas, Mikole; Kaveri, Srini, V
作者单位：Tufts University; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Universite Paris Cite
摘要：Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is proving to be an efficient treatment for many autoimmune blistering diseases, including pemphigus vulgaris (PV). Despite its widespread use and therapeutic success, its mechanisms of action are not completely understood. Some of its anti- inflammatory and immunomodulatory actions have been studied. In this study, the authors present a twenty ...
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作者：Banuelos, Allison; Zhang, Allison; Berouti, Hala; Baez, Michelle; Yilmaz, Leyla; Georgeos, Nardin; Marjon, Kristopher D.; Miyanishi, Masanori; Weissman, Irving L.
作者单位：Stanford University; Stanford University; Kobe University; Stanford University
摘要：The use of colony- stimulating factor - 1 receptor (CSF1R) inhibitors has been widely explored as a strategy for cancer immunotherapy due to their robust depletion of tumor- associated macrophages (TAMs). While CSF1R blockade effectively eliminates TAMs from the solid tumor microenvironment, its clinical efficacy is limited. Here, we use an inducible CSF1R knockout model to investigate the persistence of tumor progression in the absence of TAMs. We find increased frequencies of granulocytic my...
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作者：Xu, Jie; Gao, Xiaoyin; Zheng, Liming; Jia, Xia; Xu, Kui; Ma, Yuwei; Wei, Xiaoding; Liu, Nan; Peng, Hailin; Wang, Hong-Wei
作者单位：Tsinghua University; Tsinghua University; Chinese Academy of Sciences; Peking University; Peking University; Beijing Graphene Institute; Peking University
摘要：High- quality specimen preparation plays a crucial role in cryo- electron microscopy (cryo-EM) structural analysis. In this study, we have developed a reliable and convenient technique called the graphene sandwich method for preparing cryo-EM specimens. This method involves using two layers of graphene films that enclose macromolecules on both sides, allowing for an appropriate ice thickness for cryo-EM analysis. The graphene sandwich helps to mitigate beam- induced charging effect and reduce ...
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作者：Burkard, Guido
作者单位：University of Konstanz
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作者：Li, Juan; Xia, Yu; Song, Xiaowei; Chen, Bolei; Zare, Richard N.
作者单位：Jianghan University; Stanford University
摘要：We synthesized ammonia (NH3) by bubbling nitrogen (N-2) gas into bulk liquid water (200 mL) containing 50 mg polytetrafluoroethylene (PTFE) particles (similar to 5 mu m in diameter) suspended with the help of a surfactant (Tween 20, similar to 0.05 vol.%) at room temperature (25 degrees C). Electron spin resonance spectroscopy and density functional theory calculations reveal that water acts as the proton donor for the reduction of N2. Moreover, isotopic labeling of the N2 gas shows that it is...
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作者：Solaimuthu, Balakrishnan; Khatib, Anees; Tanna, Mayur; Karmi, Abdelrahman; Hayashi, Arata; Abu Rmaileh, Areej; Lichtenstein, Michal; Takoe, Suranjana; Jolly, Mohit Kumar; Shaul, Yoav David
作者单位：Hebrew University of Jerusalem; Indian Institute of Science Education & Research (IISER) - Berhampur; Indian Institute of Science (IISC) - Bangalore
摘要：The epithelial-mesenchymal transition (EMT) program is crucial for transforming carcinoma cells into a partially mesenchymal state, enhancing their chemoresistance, migration, and metastasis. This shift in cell state is tightly regulated by cellular mechanisms that are not yet fully characterized. One intriguing EMT aspect is the rewiring of the proteoglycan landscape, particularly the induction of heparan sulfate proteoglycan (HSPG) biosynthesis. This proteoglycan functions as a co- receptor ...
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作者：Vaudo, Anthony D.; Dyer, Lee A.; Leonard, Anne S.
作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; United States Department of Agriculture (USDA); United States Forest Service
摘要：As bees' main source of protein and lipids, pollen is critical for their development, reproduction, and health. Plant species vary considerably in the macronutrient content of their pollen, and research in bee model systems has established that this variation both modulates performance and guides floral choice. Yet, how variation in pollen chemistry shapes interactions between plants and bees in natural communities is an open question, essential for both understanding the nutritional dynamics ...
