2024

最新文章

• Hapalindole Q suppresses autophagosome-lysosome fusion by promoting YAP1 degradation via chaperon- mediated autophagy AI翻译
  作者：Wu, Yali; Wang, Shaonan; Guo, Zhicong; Sun, Min; Xu, Zhen; Du, Yu; Zhu, Fahui; Su, Yajuan; Xu, Zhou; Xu, Yi; Gong, Xu; Fang, Ruan; Hu, Jiaojiao; Peng, Yan; Ding, Zhaowen; Liu, Cong; Li, Ang; He, Weiwei
  作者单位：East China University of Science & Technology; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
  摘要：Autophagy is a conserved catabolic process crucial for maintaining cellular homeostasis and has emerged as a promising therapeutic target for many diseases. Mechanistically novel small- molecule autophagy regulators are highly desirable from a pharmacological point of view. Here, we report the macroautophagy- inhibitory effect of hapalindole Q, a member of the structurally intriguing but biologically understudied hapalindole family of indole terpenoids. This compound promotes the noncanonical ...
• We must not fool ourselves: A reply to Sethi et al. on the use of BirdNET to classify neotropical birdcalls AI翻译
  作者：de Araujo, Carlos B.
  作者单位：Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
• Emergent collective behavior evolves more rapidly than individual behavior among acorn ant species AI翻译
  作者：Doering, Grant Navid; Prebus, Matthew M.; Suresh, Sachin; Greer, Jordan N.; Bowden, Reilly; Linksvayer, Timothy A.
  作者单位：Arizona State University; Arizona State University-Tempe; Texas Tech University System; Texas Tech University; University Hohenheim; University Hohenheim
  摘要：Emergence is a fundamental concept in biology and other disciplines, but whether emergent phenotypes evolve similarly to nonemergent phenotypes is unclear. The hypothesized process of emergent evolution posits that evolutionary change in at least some collective behaviors will differ from evolutionary change in the corresponding intrinsic behaviors of isolated individuals. As a result, collective behavior might evolve more rapidly and diversify more between populations compared to individual b...
• Adhesive interactions within microbial consortia can be differentiated at the single- cell level through expansion microscopy AI翻译
  作者：Dong, Pu-Ting; Shi, Wenyuan; He, Xuesong; Borisy, Gary G.
  作者单位：Harvard University; Harvard University Medical Affiliates; Forsyth Institute
  摘要：Investigating microbe-microbe interactions at the single- cell level is critical to unraveling the ecology and dynamics of microbial communities. In many situations, microbes assemble themselves into densely packed multispecies biofilms. The density and complexity pose acute difficulties for visualizing individual cells and analyzing their interactions. Here, we address this problem through an unconventional application of expansion microscopy, which allows for the decrowding of individual bac...
• TLR priming licenses NAIP inflammasome activation by immunoevasive ligands AI翻译
  作者：Grayczyk, James P.; Liu, Luying; Egan, Marisa S.; Aunins, Emily; Dolfi, Meghan A. Wynosky -; Canna, Scott W.; Minn, Andy J.; Shin, Sunny; Brodsky, Igor E.
  作者单位：GlaxoSmithKline; Glaxosmithkline USA; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：NLR family, apoptosis inhibitory proteins (NAIPs) detect bacterial flagellin and structurally related components of bacterial type III secretion systems (T3SS), and recruit NLR family CARD domain containing protein 4 (NLRC4) and caspase-1 into an inflammasome complex that induces pyroptosis. NAIP/NLRC4 inflammasome assembly is initiated by the binding of a single NAIP to its cognate ligand, but a subset of bacterial flagellins or T3SS structural proteins are thought to evade NAIP/NLRC4 inflamm...
• A tale of two cultures: How L. Luca Cavalli- Sforza bridged the gap between science and the humanities AI翻译
  作者：Stone, Linda; Lurquin, Paul F.
  作者单位：Washington State University; Washington State University
  摘要：This article retraces the career of geneticist L. Luca CavalliSforza, from his days as a student researcher to his tenure as a Stanford University professor, and beyond. We show how Cavalli- Sforza's untiring curiosity, enthusiasm, and global knowledge led him to make incisive contributions to topics as diverse as bacterial genetics and human evolution, both biological and cultural. In an academic stood out as a scientist unafraid to promulgate and apply multidisciplinary approaches to complex...
• Self- sacrificing and self- supporting biomass carbon anode- assisted water electrolysis for low- cost hydrogen production AI翻译
  作者：Huang, Yuming; Zhou, Wei; Xie, Liang; Meng, Xiaoxiao; Li, Junfeng; Gao, Jihui; Zhao, Guangbo; Qin, Yukun
  作者单位：Harbin Institute of Technology
  摘要：Electrooxidation of renewable and CO2- neutral biomass for low- cost hydrogen production is a promising and green technology. Various biomass platform molecules (BPMs) oxidation assisted hydrogen production technologies have obtained noticeable progress. However, BPMs anodic oxidation is highly dependent on electrocatalysts, and the oxidation mechanism is ambiguous. Meanwhile, the complexity and insolubility of natural biomass severely constrain the efficient utilization of biomass resources. ...
• A closed- loop modular multiorgan- on- chips platform for self- sustaining and tightly controlled oxygenation AI翻译
  作者：Jiang, Nan; Ying, Guoliang; Yin, Yixia; Guo, Jie; Lozada, Jorge; Padilla, Alejandra Valdivia; Gomez, Ameyalli; de Melo, Bruna Alice Gomes; Mestre, Francisco Lugo; Gansevoort, Merel; Palumbo, Marcello; Cala, Noemi; Garciamendez-Mijares, Carlos Ezio; Kim, Ge-Ah; Takayama, Shuichi; Gerhard-Herman, Marie Denis; Zhang, Yu Shrike
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; University System of Georgia; Georgia Institute of Technology; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Sichuan University
  摘要：To mimic physiological microenvironments in organ- on- a- chip systems, physiologically relevant parameters are required to precisely access drug metabolism. Oxygen level is a critical microenvironmental parameter to maintain cellular or tissue functions and modulate their behaviors. Current organ- on- a- chip setups are oftentimes subjected to the ambient incubator oxygen level at 21%, which is higher than most if not all physiological oxygen concentrations. Additionally, the physiological ox...
• Monocytes give rise to Langerhans cells that preferentially migrate to lymph nodes at steady state AI翻译
  作者：Raquer, Hayley M.; Alfaro, Raul A. Maqueda --; Saravanan, Sanjana; Hornero, Rebeca Arroyo; Clausen, Bjoern E.; Blackmore, Andres Gottfried --; Idoyaga, Juliana
  作者单位：Stanford University; Stanford University; University of California System; University of California San Diego; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of California System; University of California San Diego
  摘要：Current evidence suggests that ontogeny may account for the functional heterogeneity of some tissue macrophages, but not others. Here, we asked whether developmental origin drives different functions of skin Langerhans cells (LCs), an embryo- derived mononuclear phagocyte with features of both tissue macrophages and dendritic cells. Using time- course analyses, bone marrow chimeras, and fate tracing models, we found that the complete elimination of embryo- derived LCs at steady state results i...
• Light-dependent switching between two flagellar beating states selects versatile phototaxis strategies in microswimmers AI翻译
  作者：Tsang, Alan C. H.; Riedel-Kruse, Ingmar H.
  作者单位：University of Hong Kong; University of Arizona; University of Arizona; University of Arizona; University of Arizona
  摘要：Microorganisms have evolved sophisticated sensor-actuator circuits to perform taxis in response to various environmental stimuli. How any given circuit can select between different taxis responses in noisy vs. saturated stimuli conditions is unclear. Here, we investigate how Euglena gracilis can select between positive vs. negative phototaxis under low vs. high light intensities, respectively. We propose three general selection mechanisms for phototactic microswimmers, and biophysical modeling...