2024

最新文章

• Maximally localized Wannier functions, interaction models, and fractional quantum anomalous Hall effect in twisted bilayer MoTe2 AI翻译
  作者：Xu, Cheng; Li, Jiangxu; Xu, Yong; Bi, Zhen; Zhang, Yang
  作者单位：University of Tennessee System; University of Tennessee Knoxville; Tsinghua University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Tennessee System; University of Tennessee Knoxville
  摘要：We investigate the moire band structures and the strong correlation effects in twisted bilayer MoTe2 for a wide range of twist angles, employing a combination of various techniques. Using large-scale first -principles calculations, we pinpoint realistic continuum modeling parameters, subsequently deriving the maximally localized Wannier functions for the top three moire bands. Simplifying our model with reasonable assumptions, we obtain a minimal two -band model, encompassing Coulomb repulsion...
• A nonadaptive explanation for macroevolutionary patterns in the evolution of complex multicellularity AI翻译
  作者：Bingham, Emma P.; Ratcliff, William C.
  作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology
  摘要：Complex multicellularity, conventionally defined as large organisms with many specialized cell types, has evolved five times independently in eukaryotes, but never within prokaryotes. A number of hypotheses have been proposed to explain this phenomenon, most of which posit that eukaryotes evolved key traits (e.g., dynamic cytoskeletons, alternative mechanisms of gene regulation, or subcellular compartments) which were a necessary prerequisite for the evolution of complex multicellularity. Here...
• Phase separation of YAP-MAML2 differentially regulates the transcriptome AI翻译
  作者：Chung, Chan-, I; Yang, Junjiao; Yang, Xiaoyu; Liu, Hongjiang; Ma, Zhimin; Szulzewsky, Frank; Holland, Eric C.; Shen, Yin; Shu, Xiaokun
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center
  摘要：Phase separation (PS) drives the formation of biomolecular condensates that are emerging biological structures involved in diverse cellular processes. Recent studies have unveiled PS- induced formation of several transcriptional factor (TF) condensates that are transcriptionally active, but how strongly PS promotes gene activation remains unclear. Here, we show that the oncogenic TF fusion Yes- associated protein 1- Mastermind like transcriptional coactivator 2 (YAP- MAML2) undergoes PS and fo...
• Buckling-induced sound production in the aeroelastic tymbals of Yponomeuta AI翻译
  作者：Nava, Hernaldo Mendoza; Holderied, Marc W.; Pirrera, Alberto; Groh, Rainer M. J.
  作者单位：University of Bristol; University of Bristol
  摘要：The loss of elastic stability (buckling) can lead to catastrophic failure in the context of traditional engineering structures. Conversely, in nature, buckling often serves a desirable function, such as in the prey -trapping mechanism of the Venus fly trap (Dionaea muscipula). This paper investigates the buckling -enabled sound production in the wingbeat-powered (aeroelastic) tymbals of Yponomeuta moths. The hindwings of Yponomeuta possess a striated band of ridges that snap through sequential...
• TM4SF19 controls GABP- dependent YAP transcription in head and neck cancer under oxidative stress conditions AI翻译
  作者：Shin, Eunbie; Kwon, Yongsoo; Jung, Eunji; Kim, Yong Joon; Kim, Changgon; Hong, Semyeong; Kim, Joon
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Yonsei University; Yonsei University Health System
  摘要：Tobacco and alcohol are risk factors for human papillomavirus-negative head and neck squamous cell carcinoma (HPV- HNSCC), which arises from the mucosal epithelium of the upper aerodigestive tract. Notably, despite the mutagenic potential of smoking, HPV- HNSCC exhibits a low mutational load directly attributed to smoking, which implies an undefined role of smoking in HPV- HNSCC. Elevated YAP (Yes- associated protein) mRNA is prevalent in HPV- HNSCC, irrespective of the YAP gene amplification ...
• A cholesterol- binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells AI翻译
  作者：Xu, Shimeng; Smothers, Jared C.; Rye, Daphne; Endapally, Shreya; Chen, Hong; Li, Shili; Liang, Guosheng; Kinnebrew, Maia; Rohatgi, Rajat; Posner, Bruce A.; Radhakrishnan, Arun
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Stanford University; Stanford University
  摘要：Lipid synthesis is regulated by the actions of Scap, a polytopic membrane protein that binds cholesterol in membranes of the endoplasmic reticulum (ER). When ER cholesterol levels are low, Scap activates SREBPs, transcription factors that upregulate genes for synthesis of cholesterol, fatty acids, and triglycerides. When ER cholesterol levels rise, the sterol binds to Scap, triggering conformational changes that prevent activation of SREBPs and halting synthesis of lipids. To achieve a molecul...
• Bodily maps of musical sensations across cultures AI翻译
  作者：Putkinen, Vesa; Zhou, Xinqi; Gan, Xianyang; Yang, Linyu; Becker, Benjamin; Sams, Mikko; Nummenmaa, Lauri
  作者单位：University of Turku; University of Turku; Sichuan Normal University; University of Electronic Science & Technology of China; Sichuan Provincial People's Hospital; University of Electronic Science & Technology of China; Sichuan University; University of Hong Kong; University of Hong Kong; Aalto University; University of Turku
  摘要：Emotions, bodily sensations and movement are integral parts of musical experiences. Yet, it remains unknown i) whether emotional connotations and structural features of music elicit discrete bodily sensations and ii) whether these sensations are culturally consistent. We addressed these questions in a cross- cultural study with Western (European and North American, n = 903) and East Asian (Chinese, n = 1035). We precented participants with silhouettes of human bodies and asked them to indicate...
• A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea AI翻译
  作者：Mottaghinia, Saba; Stenzel, Saskia; Tsangaras, Kyriakos; Nikolaidis, Nikolas; Laue, Michael; Mueller, Karin; Hoelscher, Henriette; Loeber, Ulrike; Mcewen, Gayle K.; Donnellan, Stephen C.; Rowe, Kevin C.; Aplin, Ken P.; Goffinet, Christine; Greenwood, Alex D.
  作者单位：Leibniz Institut fur Zoo und Wildtierforschung; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Liverpool School of Tropical Medicine; University of Nicosia; California State University System; California State University Fullerton; California State University System; California State University Fullerton; Robert Koch Institute; Helmholtz Association; Max Delbruck Center for Molecular Medicine; South Australian Museum; Free University of Berlin
  摘要：Germline colonization by retroviruses results in the formation of endogenous retroviruses (ERVs). Most colonization's occurred millions of years ago. However, in the Australo- Papuan region (Australia and New Guinea), several recent germline colonization events have been discovered. The Wallace Line separates much of Southeast Asia from the Australo- Papuan region restricting faunal and pathogen dispersion. West of the Wallace Line, gibbon ape leukemia viruses (GALVs) have been isolated from c...
• The photonic content of a transmission-line pulse AI翻译
  作者：Varvelis, Evangelos; Biswas, Debjyoti; DiVincenzo, David P.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Helmholtz Association; Research Center Julich
  摘要：We develop a photonic description of short, one-dimensional electromagnetic pulses, specifically in the language of electrical transmission lines. Current practice in quantum technology, using arbitrary waveform generators, can readily produce very short, fewcycle pulses in a very -low -noise, low -temperature setting. We argue that these systems attain the limit of producing pure coherent quantum states, in which the vacuum has been displaced for a short time, and therefore over a short spati...
• Academics are more specific, and practitioners more sensitive, in forecasting interventions to strengthen democratic attitudes AI翻译
  作者：Chua, James Y.; Voelkelb, Jan G.; Stagnaroc, Michael N.; Kang, Suji; Druckman, James N.; Rand, David G.; Willer, Robb
  作者单位：Columbia University; Stanford University; Massachusetts Institute of Technology (MIT); University of Pennsylvania; University of Rochester
  摘要：Concern over democratic erosion has led to a proliferation of proposed interventions to strengthen democratic attitudes in the United States. Resource constraints, however, prevent implementing all proposed interventions. One approach to identify promising interventions entails leveraging domain experts, who have knowledge regarding a given field, to forecast the effectiveness of candidate interventions. We recruit experts who develop general knowledge about a social problem (academics), exper...