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作者：Juan, Thomas; Bellec, Maeelle; Cardoso, Barbara; Athea, Heloise; Fukuda, Nana; Albu, Marga; Guenther, Stefan; Looso, Mario; Stainier, Didier Y. R.
作者单位：Max Planck Society; German Centre for Cardiovascular Research; Max Planck Society; Max Planck Society
摘要：Cardiac contractions and hemodynamic forces are essential for organ development and homeostasis. Control over cardiac contractions can be achieved pharmacologically or optogenetically. However, these approaches lack specificity or require direct access to the heart. Here, we compare two genetic approaches to control cardiac contractions by modulating the levels of the essential sarcomeric protein Tnnt2a in zebrafish. We first recombine a newly generated tnnt2a floxed allele using multiple line...
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作者：Radulovic, Maja; Stenmark, Harald
作者单位：University of Oslo
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作者：Tazai, Rina; Yamakawa, Youichi; Kontani, Hiroshi
作者单位：Kyoto University; Nagoya University
摘要：In kagome metals, the chiral current order parameter eta with time-reversal-symmetry-breaking is the source of various exotic electronic states, while the method of controlling the current order and its interplay with the star-of-David bond order phi are still unsolved. Here, we reveal that tiny uniform orbital magnetization M-orb[eta, phi] is induced by the chiral current order, and its magnitude is prominently enlarged under the presence of the bond order. Importantly, we derive the magnetic...
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作者：Ulschmid, Caden M.; Sun, Miranda R.; Jabbarpour, Christopher R.; Steward, Austin C.; Rivera-Gonzalez, Kenneth S.; Cao, Jocelyn; Martin, Alexander A.; Barnes, Macy; Wicklund, Lorena; Madrid, Andy; Papale, Ligia A.; Joseph, Diya B.; Vezina, Chad M.; Alisch, Reid S.; Lipinski, Robert J.
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Orofacial clefts of the lip and palate are widely recognized to result from complex gene-environment interactions, but inadequate understanding of environmental risk factors has stymied development of prevention strategies. We interrogated the role of DNA methylation, an environmentally malleable epigenetic mechanism, in orofacial devel-opment. Expression of the key DNA methyltransferase enzyme DNMT1 was detected throughout palate morphogenesis in the epithelium and underlying cranial neural c...
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作者：Zhou, Chuan-Miao; Li, Jian-Xu; Zhang, Tian-Qi; Xu, Zhou-Geng; Ma, Miao-Lian; Zhang, Peng; Wang, Jia-Wei
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Shanghai Chenshan Botanical Garden; Chinese Academy of Sciences; ShanghaiTech University
摘要：The phytohormone cytokinin has various roles in plant development, including meristem maintenance, vascular differentiation, leaf senescence, and regeneration. Prior investiga- tions have revealed that cytokinin acts via a phosphorelay similar to the two-component system by which bacteria sense and respond to external stimuli. The eventual tar- gets of this phosphorelay are type-B ARABIDOPSIS RESPONSE REGULATORS (B-ARRs), containing the conserved N-terminal receiver domain (RD), middle DNA bin...
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作者：Zhang, Yuxi; Mazal, Hisham; Mandala, Venkata Shiva; Perez-Mitta, Gonzalo; Sondoghdar, Vahid; Haselwandter, Christoph A.; Mackinnon, Roderick
作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Max Planck Society; University of Erlangen Nuremberg; University of Southern California; University of Southern California
摘要：This study shows that five membrane proteins-three GPCRs, an ion channel, and an enzyme-form self- clusters under natural expression levels in a cardiac- derived cell line. The cluster size distributions imply that these proteins self- oligomerize reversibly through weak interactions. When the concentration of the proteins is increased through heterologous expression, the cluster size distributions approach a critical distribution at which point a phase transition occurs, yielding larger bulk ...
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作者：Wang, Baoliang; Moynier, Frederic; Hu, Yan
作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS)
摘要：The planetesimals in the solar system exhibit varying degrees of moderately volatile elements (MVEs) depletion compared to the protosolar composition. Revealing the relevant mechanisms is crucial for exploring early solar system evolution. Most volatile- depleted materials in the solar system exhibit enrichments in the heavier isotopes of MVEs, which have traditionally been attributed to the loss of volatiles through partial evaporation. Angrites are so far an exception as they are enriched in...
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作者：Chepizhko, Oleksandr; Armengol-Collado, Josep-Maria; Alexander, Stephanie; Wagena, Esther; Weigelin, Bettina; Giomi, Luca; Friedi, Peter; Zapperi, Stefano; La Porta, Caterina A. M.
作者单位：Leiden University; Leiden University - Excl LUMC; University of Texas System; UTMD Anderson Cancer Center; University of Wurzburg; University of Wurzburg; Radboud University Nijmegen; University of Milan; Consiglio Nazionale delle Ricerche (CNR); Istituto di Chimica della Materia Condensata e di Tecnologie per l Energia (ICMATE-CNR); University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Eberhard Karls University of Tubingen
摘要：Collective migration of cancer cells is often interpreted using concepts derived from the physics of active matter, but the experimental evidence is mostly restricted to observations made in vitro. Here, we study collective invasion of metastatic cancer cells injected into the mouse deep dermis using intravital multiphoton microscopy combined with a skin window technique and three-dimensional quantitative image analysis. We observe a multicellular but low-cohesive migration mode characterized ...
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作者：Kazerani, Maryam; Cernilogar, Filippo; Pasquarella, Alessandra; Hinterberger, Maria; Nuber, Alexander; Klein, Ludger; Schotta, Gunnar
作者单位：Bavarian Nordic; University of Munich; University of Eastern Piedmont Amedeo Avogadro; University of Munich
摘要：The H3K9me3- specific histone methyltransferase SETDB1 is critical for proper regulation of developmental processes, but the underlying mechanisms are only partially understood. Here, we show that deletion of Setdb1 in mouse fetal liver hematopoietic stem and progenitor cells (HSPCs) results in compromised stem cell function, enhanced myeloerythroid differentiation, and impaired lymphoid development. Notably, Setdb1- deficient HSPCs exhibit reduced quiescence and increased proliferation, accom...
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作者：Reiss, Philipp
作者单位：Technical University of Munich
摘要：The presence of water on the Moon has been indicated by various remote- sensing observations and analyses of returned samples. Several missions are planned to conduct new in situ research on the lunar surface to directly observe and characterize lunar water. A comprehensive characterization of the present forms of water, their abundance, spatial distribution, temporal variation, and possible origin is required to understand the lunar water cycle and the relevance of individual source and sink ...
