2024

最新文章

• Pathogenic mechanism and therapeutic intervention of impaired N7-methylguanosine (m7G) tRNA modification AI翻译
  作者：Ma, Jieyi; Zheng, Siyi; An, Chenrui; Han, Hui; Li, Qiwen; Huang, Ying; Xiong, Gan; Chen, Shuang; Guo, Siyao; Wang, Zhaoyu; Wei, Wei; Shang, Yudan; Ji, Yushan; Yang, Cuiyun; Choe, Junho; Yuan, Quan; Fan, Yong; Zhang, Canfeng; Lin, Shuibin
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Guangzhou Medical University; Sichuan University; Sichuan University; Sun Yat Sen University; Hanyang University; Hanyang University; Hanyang University; Hanyang University; Sun Yat Sen University
  摘要：Mutations modification enzymes including the tRNA N-7-methylguanosine (m(7)G) methyltransferase complex component WDR4 were frequently found in patients with neural disorders, while the pathogenic mechanism and therapeutic intervention strategies are poorly explored. In this study, we revealed that patient-derived WDR4 mutation leads to temporal and cell-type-specific neural degeneration, and directly causes neural developmental disorders in mice. Mechanistically, WDR4 point mutation disrupts ...
• Soil viral-host interactions regulate microplastic- dependent carbon storage AI翻译
  作者：Wang, Lu; Lin, Da; Xiao, Ke - Qing; Ma, Li - Juan; Fu, Yan - Mei; Huo, Yu - Xin; Liu, Yanjie; Ye, Mao; Sun, Ming - Ming; Zhu, Dong; Rillig, Matthias C.; Zhu, Yong - Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Hebei University; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Nanjing Agricultural University; Free University of Berlin
  摘要：Microplastic is globally regarded as an important factor impacting biogeochemical cycles, yet our understanding of such influences is limited by the uncertainties of intricate microbial processes. By multiomics analysis, coupled with soil chemodiversity characterization and microbial carbon use efficiency (CUE), we investigated how microbial responses to microplastics impacted soil carbon cycling in a long- term field experiment. We showed that biodegradable microplastics promoted soil organic...
• A molecular view of peptoid- induced acceleration of calcite growth AI翻译
  作者：Zhang, Mingyi; Chen, Ying; Wu, Chunhui; Zheng, Renyu; Xia, Ying; Saccuzzo, Emily G.; Trinh, Thi Kim Hoang; Mondarte, Evan Angelo Quimada; Nakouzi, Elias; Rad, Behzad; Legg, Benjamin A.; Shaw, Wendy J.; Tao, Jinhui; De Yoreo, James J.; Chen, Chun-Long
  作者单位：United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The extensive deposits of calcium carbonate (CaCO3) generated by marine organisms constitute the largest and oldest carbon dioxide (CO2) reservoir. These organisms utilize macromolecules like peptides and proteins to facilitate the nucleation and growth of carbonate minerals, serving as an effective method for CO2 sequestration. However, the precise mechanisms behind this process remain elusive. In this study, we report the use of sequence- defined peptoids, a class of peptidomimetics, to achi...
• Biochemical analysis of EGFR exon20 insertion variants insASV and insSVD and their inhibitor sensitivity AI翻译
  作者：Zhao, Hanchen; Beyett, Tyler S.; Jiang, Jie; Rana, Jaimin K.; Schaeffner, Ilse K.; Santana, Jhasmer; Janne, Pasi A.; Eck, Michael J.
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Emory University
  摘要：Somatic mutations in the epidermal growth factor receptor (EGFR) are a major cause of non-small cell lung cancer. Among these structurally diverse alterations, exon 20 insertions represent a unique subset that rarely respond to EGFR tyrosine kinase inhibitors (TKIs). Therefore, there is a significant need to develop inhibitors that are active against this class of activating mutations. Here, we conducted biochemical analysis of the two most frequent exon 20 insertion variants, V769_D770insASV ...
• Film intervention increases empathic understanding of formerly incarcerated people and support for criminal justice reform AI翻译
  作者：Reddan, Marianne C.; Garcia, Sydney B.; Golarai, Golijeh; Eberhardt, Jennifer L.; Zaki, Jamil
  作者单位：Stanford University; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Princeton University; Stanford University; Stanford University
  摘要：Nuanced portrayals of stigmatized groups in media have been shown to reduce prejudice. In an online experiment (N = 749), we tested whether a feature film depicting incarcerated peoples' experiences in the criminal justice system can increase a) empathic accuracy and compassion toward people who have been incarcerated and b) support for criminal justice reform. We measured baseline empathic accuracy via a well- validated task, where participants infer the emotions of people sharing stories abo...
• CXCL13 promotes broad immune responses induced by circular AI翻译
  作者：Wan, Jiawu; Wang, Caiqian; Wang, Zongmei; Wang, Lingli; Wang, Haoran; Zhou, Ming; Fu, Zhen F.; Zhao, Ling
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Huazhong Agricultural University
  摘要：Antibody responses induced by current vaccines for influenza and SARS- CoV- 2 often alterations in the immune microenvironment within lymph nodes (LNs) are intricately circular RNA (circRNA) and targeted to LNs, in which CXCL13 was directly integrated into antigen- encoding circRNA strands. We demonstrated that CXCL13 alters the tranCXCL13 promotes the formation of germinal center and elicits robust antigen- specific T cell responses. With the codelivery of CXCL13 and the antigen, CXCL13 enhan...
• Temporal covariation of island arc Sr isotopes and seawater chemistry over the past 2 billion years AI翻译
  作者：Bednarick, Amanda L.; Bucholz, Claire E.; Depaolo, Donald J.; Stolper, Daniel A.
  作者单位：California Institute of Technology; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The chemical compositions of island arc basalts (IAB) reflect contributions from the mantle as well as fluids and melts from the subducting slab. Addition of radiogenic seawater Sr to oceanic crust through hydrothermal alteration and subsequent subduction is often invoked to explain elevated 87 Sr/ 86 Sr signatures in modern IAB. However, changes in the 87 Sr/ 86 Sr of island arc magmatic rocks through time has not been investigated, limiting our understanding of the factors influencing the Sr...
• Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre-tRNA cleavage AI翻译
  作者：Liang, Xiaoge; Chen, Dian; Su, Aimin; Liu, Yu
  作者单位：Shanghai Jiao Tong University
  摘要：Ribonuclease P (RNase P) plays a vital role in the maturation of tRNA across bacteria, archaea, and eukaryotes. However, how RNase P assembles various components to achieve specific cleavage of precursor tRNA (pre-tRNA) in different organisms remains elusive. In this study, we employed single- molecule fluorescence resonance energy transfer to probe the dynamics of RNase P from E. coli ( Escherichia coli) and Mja ( Methanocaldococcus jannaschii) during pre-tRNA cleavage by incorporating five C...
• Cobalt-based pyroxenes: A new playground for Kitaev physics AI翻译
  作者：Maksimov, Pavel A.; Ushakov, Alexey, V; Gubkin, Andrey F.; Redhammer, Guenther J.; Winter, Stephen M.; Kolesnikov, Alexander I.; Santos, Antonio M. dos; Gai, Zheng; Mcguire, Michael A.; Podlesnyak, Andrey; Streltsov, Sergey, V
  作者单位：Joint Institute for Nuclear Research - Russia; Russian Academy of Sciences; Institute of Metal Physics UB RAS; Ural Federal University; Salzburg University; Wake Forest University; Wake Forest University; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences; United States Department of Energy (DOE); Oak Ridge National Laboratory; Ural Federal University
  摘要：Recent advances in the study of cobaltites have unveiled their potential as a promising platform for realizing Kitaev physics in honeycomb systems and the Ising model in weakly coupled chain materials. In this manuscript, we explore the magnetic properties of pyroxene SrCoGe2O6 using a combination of neutron scattering, ab initio methods, and linear spin-wave theory. Through careful examination of inelastic neutron scattering powder spectra, we propose a modified Kitaev model to accurately des...
• Contextualizing racial associations in gene expression in patients with uterine serous carcinoma AI翻译
  作者：Rollin, Francois G.; Patel, Shree A.; McCachren, Samuel S.
  作者单位：Emory University; Emory University