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作者：Parvez, Riana K.; Kim, Doh Kyung; Csipan, Reka L.; Guo, Jinjin; Zeng, Zipeng; Zhang, Chennan C.; Li, Zhongwei; McMahon, Andrew P.
作者单位：University of Southern California; University of Southern California; California Institute of Technology
摘要：Intercalated cells (ICs) in the mammalian kidney regulate circulatory pH through IC subtype-restricted actions of bicarbonate transporters: pH is elevated by Slc4a1 restricted to type A-ICs (A-ICs) and depressed by Slc26a4 in type B-IC (B-ICs). NonA-nonB-ICs (nA/nB-ICs) also produce Slc26a4 though their function is unclear. Though both nephron and ureteric progenitor lineages generate A-ICs, the former also generates nA/nB-ICs and the latter B-ICs. Lineage and cell type restricted transporter ...
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作者：Mueller, Tobias; Thomale, Ronny; Sachdev, Subir; Iqbal, Yasir
作者单位：University of Wurzburg; University of Zurich; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Harvard University
摘要：We employ a family of ancilla qubit variational wave functions [Y.-H. Zhang and Sachdev, Phys. Rev. Res. 2, 023172 (2020)] to describe the polaronic correlations the pseudogap metal phase of a hole-doped 2D Fermi-Hubbard model. Comparison to ultracold atom quantum simulator data [J. Koepsell etal., Science 374, 82 (2021)] reveals both qualitative and quantitative agreement with the numerical analysis from half-filling up to 80% hole-doping, capturing the crossover from the polaronic regime to ...
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作者：Fan, Weiwei; Oh, Tae Gyu; Wang, Hui J.; Crossley, Lillian; He, Mingxiao; Robbins, Hunter; Koopari, Chandra; Dai, Yang; Truitt, Morgan L.; Liddle, Christopher; Yu, Ruth T.; Atkins, Annette R.; Downes, Michael; Evans, Ronald M.
作者单位：Salk Institute; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Sydney; Westmead Institute for Medical Research; University of Sydney
摘要：Mitochondrial energy metabolism is vital for muscle function and is tightly controlled at the transcriptional level, both in the basal state and during adaptive muscle remodeling. The importance of the transcription factors estrogen-related receptors (ERRs) in controlling innate mitochondrial energetics has been recently demonstrated. However, whether different ERR isoforms display distinct functions in glycolytic versus oxidative myofibers is largely unknown. Moreover, their roles in regulati...
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作者：Lehr, Steven A.; Saichandran, Ketan S.; Harmon-Jones, Eddie; Vitali, Nykko; Banaji, Mahzarin R.
作者单位：Boston University; University of New South Wales Sydney; Harvard University
摘要：Large language models (LLMs) show emergent patterns that mimic human cognition. We explore whether they also mirror other, less deliberative human psychological processes. Drawing upon classical theories of cognitive consistency, two preregistered studies tested whether GPT-4o changed its attitudes toward Vladimir Putin in the direction of a positive or negative essay it wrote about the Russian leader. Indeed, GPT displayed patterns of attitude change mimicking cognitive dissonance effects in ...
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作者：Olszakier, Shunit; Hussein, Wessal; Heinrich, Ronit; Andreyanov, Michael; Blau, Achinoam; Otor, Yara; Schiller, Jackie; Kellner, Shai; Berlin, Shai
作者单位：Technion Israel Institute of Technology; Rappaport Faculty of Medicine
摘要：Genetically encoded calcium indicators (GECIs) have revolutionized the study of cellular calcium signaling, offering powerful tools for real-time optical monitoring of calcium dynamics. Although contemporary GECIs can be targeted to various organelles, there are no means to obtain active and functional GECIs exclusively at interorganellar junctions. To address this gap, we have developed a toolbox of split versions of green and red GECIs designed to reassemble only when the two halves come int...
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作者：Soriaga, Leah B.; Balce, Dale R.; Bartha, Istvan; Park, Arnold; Wong, Emily; McAllaster, Michael; Mueller, Elizabeth A.; Barauskas, Ona; Carabajal, Esteban; Kowalski, Beatriz; Lee, Sooyoung; Lo, Gary; Mahoney, Tara F.; Metruccio, Matteo; Sahakyan, Anna; Somasundaram, Logeshwaran; Steinfeld, Tod; Wang, Lisha; Wedel, Laura; Yim, Samantha S.; Yin, Li; Zhou, Jiayi; Newby, Zach; Tse, Winston; Grosse, Johannes; Virgin, Herbert W.; Hwang, Seungmin; Telenti, Amalio
作者单位：Washington University (WUSTL); University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Respiratory viruses represent a major global health burden. Although these viruses have different life cycles, they may depend on common host genetic factors, which could be targeted by broad-spectrum host-directed therapies. We used genome-wide CRISPR screens and advanced data analytics to map a network of host genes that support infection by nine human respiratory viruses [influenza A virus, parainfluenza virus, human rhinovirus, respiratory syncytial virus, human coronavirus (HCoV)-229E, HC...
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作者：Erb, Alexander; Kind, Jonas; Zankel, Timon L.; Stark, Robert W.; Thiele, Christina M.
作者单位：Technical University of Darmstadt; Technical University of Darmstadt
摘要：Evaporation of sessile multicomponent droplets is ubiquitous in many common processes, such as printing, cooling, and coating. The evaporation rate is not evenly distributed across the surface of the droplet. As a result, there are regions with high evaporation rates in which the more volatile part evaporates preferentially; this can induce local surface tension gradients, which, in combination with density differences, can lead to flows within the droplet originating from local concentration ...
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作者：Juna, Dong-Jae; Schumacher, Marc M.; Joa, Youngah; Faulkner, Rebecca A.; Yang, Yangyang; Tsien, Jet; Qin, Tian; DeBose-Boyd, Russell A.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Dallas Baptist University
摘要：Schnyder corneal dystrophy (SCD) is a rare autosomal dominant condition characterized by the opacification of the cornea owing to the abnormal deposition of cholesterol. SCD-associated mutations have been identified in the gene encoding UbiA prenyltransferase domain-containing protein-1 (UBIAD1), which uses geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4 (MK-4). Beyond its enzymatic role, UBIAD1 serves as a key regulator of the endoplasmic reticulum (ER)-...
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作者：Pacella, Gina N.; Kuprasertkul, Nina; Bao, Lydia; Huang, Sijia; D'souza, Carina; Prouty, Stephen M.; Anderson, Amy; Lopez, Alexandra M. Maldonado; Sinkfield, Morgan; Olingou, Cyria; Seykora, John T.; Capell, Brian C.
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine
摘要：The X-linked histone demethylase, UTX (KDM6A), is a master regulator of gene enhancers, though its role in self-renewing epithelia like the skin is not well understood. Here, we find that UTX is a key regulator of skin differentiation via the regulation of retinoic acid (RA) signaling, an essential metabolic pathway in both skin homeostasis, as well as in the treatment of an array of skin conditions ranging from cancer and acne to aging. Through deletion of Utx in the skin, we demonstrate dire...
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作者：Wang, Jun; Liao, Long; Yang, Bo; Miao, Beiping; Bernards, Rene; Qin, Wenxin; Sun, Chong; Wang, Cun
作者单位：Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Helmholtz Association; German Cancer Research Center (DKFZ); Netherlands Cancer Institute
