-
作者：Xu, Luo; Zeng, Hongtai; Lin, Ning; Yang, Yue; Guo, Qinglai; Poor, H. Vincent
作者单位：Princeton University; Princeton University; Tsinghua University; Hefei University of Technology; Hefei University of Technology; Princeton University
摘要：Distribution networks, with large-scale integration of distributed renewable resources, particularly rooftop solar photovoltaic systems, represent the most extensive yet vulnerable components of modern electric power systems during climate extremes such as hurricanes. However, existing day-ahead electricity dispatch approaches primarily focus on the transmission network and lack the capability to manage the spatiotemporal risks associated with the vast distribution networks, which can potentia...
-
作者：Cui, Yongxing; Peng, Shushi; Rillig, Matthias C.; Camenzind, Tessa; Delgado-Baquerizo, Manuel; Terrer, Cesar; Xu, Xiaofeng; Feng, Maoyuan; Wang, Mengjie; Fang, Linchuan; Zhu, Biao; Du, Enzai; Moorhead, Daryl L.; Sinsabaugh, Robert L.; Penuelas, Josep; Elser, James J.
作者单位：Peking University; Free University of Berlin; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); Massachusetts Institute of Technology (MIT); California State University System; San Diego State University; Wuhan University of Technology; Peking University; Peking University; Beijing Normal University; University System of Ohio; University of Toledo; University of New Mexico; Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Barcelona; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); University of Montana System; University of Montana; University of Montana System; University of Montana; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
摘要：The availability of nitrogen (N) and phosphorus (P) is essential for soil microbial activity and growth, yet global patterns of N and P limitation in soil microbial metabolism remain largely unknown. We modeled ecoenzyme stoichiometry data from 5,259 field observations of natural ecosystems to assess microbial N and P limitation in global surface soils. We found that microbial P limitation, which was especially strong at low latitudes, was more prevalent globally than microbial N limitation, w...
-
作者：Pettygrove, Brian A.; Nygaard, Tyler K.; Borgogna, Timothy R.; Malachowa, Natalia; Gaur, Gauri; Salo, Shannon E.; Pallister, Kyler B.; Burroughs, Owen; Robinson, Cassandra; Gao, Annika; Sturdevant, Daniel E.; Ricklefs, Stacy; DeLeo, Frank R.; Otto, Michael; Stewart, Philip S.; Voyich, Jovanka M.
作者单位：Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Montana State University System; Montana State University Bozeman
摘要：Staphylococcus aureus (S. aureus) is a frequent culprit in implant-associated infections and employs many virulence factors to escape killing by the host immune system. The specific immune evasion strategies used by small aggregates of S. aureus on a surface, precursors to mature biofilm, are still relatively unknown. Time-lapse confocal microscopy was leveraged to quantify interactions between S. aureus aggregates and human neutrophils in vitro and identify specific mechanisms of resistance t...
-
作者：Yanga, Brenda; Rutkowskia, Natalie; Rutaa, Anna; Gray-Gaillarda, Elise; Maestas Jr, David R.; Kellya, Sean H.; Krishnana, Kavita; Wub, Xinqun; Wub, Shaoguang; Chenc, Allen; Mejias, Joscelyn C.; Hooksa, Joshua S. T.; Vanderzeea, Isabel; Mensaha, Patricia; Celika, Nazmiye; Erica, Marie; Abrahama, Peter; Tamd, Ada; Housseaud, Franck; Pardolld, Drew M.; Sears, Cynthia L.; Elisseeffa, Jennifer H.
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
摘要：The gut microbiota influences systemic immunity and the function of distal tissues, including the brain, liver, skin, lung, and muscle. However, the role of the gut microbiota in the foreign body response and fibrosis is largely unexplored. To investigate this connection, we perturbed the homeostasis of the murine gut microbiota via infection with the pathogenic bacterial species enterotoxigenic Bacteroides fragilis (ETBF) and implanted particulate material (mean particle size <600 mu m) of th...
-
作者：Dekker, Tessa M.; Maimon-Mor, Roni O.
作者单位：University of London; University College London; University of London; University College London
-
作者：Kroy, Klaus
作者单位：Leipzig University
-
作者：Abundo, Maria Paulene; Tifrea, Anna T.; Buss, Marjorie T.; Larrea, Pierina Barturen -; Jin, Zhiyang; Malounda, Dina; Shapiro, Mikhail G.
作者单位：California Institute of Technology; California Institute of Technology; Howard Hughes Medical Institute
摘要：Delivering biomedicines to specific sites of disease using remote-controlled devices is a long-standing vision in biomedical research. However, most existing externally triggered delivery systems are based on complex micromachines that are controlled with electromagnetic waves and require custom external instrumentation. Here, we present a drug delivery platform based on a simple protein-containing hydrogel that can be both imaged and triggered to release drugs at specific locations using wide...
-
作者：Creighton, Maria J. A.; Lerch, Brian A.; Lange, Elizabeth C.; Silk, Joan B.; Tung, Jenny; Archie, Elizabeth A.; Alberts, Susan C.
作者单位：Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Duke University; Duke University; Max Planck Society; Canadian Institute for Advanced Research (CIFAR); University of Notre Dame
摘要：Over the past few decades, studies have provided strong evidence that the robust links between the social environment, health, and survival found in humans also extend to nonhuman social animals. A number of these studies emphasize the early life origins of these effects. For example, in several social mammals, more socially engaged mothers have infants with higher rates of survival compared to less socially engaged mothers, suggesting that positive maternal social relationships causally impro...
-
作者：Dong, Chenyu; Faranda, Davide; Gualandi, Adriano; Lucarini, Valerio; Mengaldo, Gianmarco
作者单位：National University of Singapore; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite PSL; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut Polytechnique de Paris; Ecole Normale Superieure (ENS); Ecole Polytechnique; University of Cambridge; Istituto Nazionale Geofisica e Vulcanologia (INGV); University of Leicester; National University of Singapore
摘要：Nonlinear dynamical systems are ubiquitous in nature and they are hard to forecast. Not only they may be sensitive to small perturbations in their initial conditions, but they are often composed of processes acting at multiple scales. Classical approaches based on the Lyapunov spectrum rely on the knowledge of the dynamic forward operator, or of a data-derived approximation of it. This operator is typically unknown, or the data are too noisy to derive its faithful representation. Here, we prop...
-
作者：Selig, Emily E.; Sohn, Erich J.; Stoja, Aiola; Moreno-Romero, Alma K.; Akula, Shivani; Xu, Xiaoping; Bishop, Alexander J. R.; Libich, David S.
作者单位：University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
摘要：Ewing sarcoma (EwS) is an aggressive cancer of bone and soft tissue that predominantly affects children and young adults. A chromosomal translocation joins the low-complexity domain (LCD) of the RNA-binding protein EWS (EWSLCD) with the DNA-binding domain of Friend leukemia integration 1 (FLI1(DBD)), creating EWS::FLI1, a potent fusion oncoprotein essential for EwS development and responsible for over 85% of EwS tumors. EWS::FLI1 forms biomolecular condensates in vivo and promotes tumorigenesi...
