20期

最新文章

• Cyclization of archaeal membrane lipids impacts membrane protein activity and archaellum formation AI翻译
  作者：Yang, Wei; Feng, Xi; Chen, Huahui; Liman, Geraldy Lie Stefanus; Santangelo, Thomas J.; Zhang, Changyi; Zeng, Zhirui
  作者单位：Southern University of Science & Technology; Colorado State University System; Colorado State University Fort Collins; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Enhancement of the cyclization of membrane lipids GDGTs (glycerol dialkyl glycerol tetraethers) is a critical strategy for archaea to adapt to various environmental stresses. However, the physiological function of membrane lipid cyclization remains unclear. Here, we reported that the GDGT ring synthases mutant, deficient in GDGT cyclization, inhibited archaellum formation and reduced cell motility in thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. This inhibition was caused by decrea...
• A founding father of neuroscience: Floyd E. Bloom, 1936-2025 AI翻译
  作者：Aston-Jones, Gary; Foote, Stephen L.; Morrison, John H.
  作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
  摘要：Floyd E. Bloom, M.D. was a prominent leader and spokesperson for the neuroscience and broader scientific communities; sadly, were focused on multidisciplinary characterizations of transmitter- specific neural pathways in the brain. An innovative neuroanatomist and neurophysiologist, he spearheaded the development of new techniques and multidisciplinary paradigms for demonstrating the functions of neurotransmitters at the circuit, cellular, and subcellular levels. His work was especially import...
• Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes AI翻译
  作者：Sakamoto, Takashi; Leca, Julie; Zhang, Xin; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Hendrikse, Liam D.; Zhou, Wenjing; Berger, Thorsten; Fortin, Jerome; Chan, Steven M.; Chiang, Ming-Feng; Inoue, Satoshi; Li, Wanda Y.; Chu, Mandy F.; Duncan, Gordon S.; Wakeham, Andrew; Lemonnier, Francois; Tobin, Chantal; Mcwilliam, Ryan; Colonna, Isabelle; Bontoux, Christophe; Jafari, Soode Moghadas; Bowman, Robert L.; Nicolay, Brandon; Ronseaux, Sebastien; Narayanaswamy, Rohini; Levine, Ross L.; Melnick, Ari M.; Mason, Christopher E.; Minden, Mark D.; Mak, Tak W.
  作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; Kyoto University; UNICANCER; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Lyon 1; Centre Leon Berard; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; McGill University; National Cancer Center - Japan; Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute d'universites et etablissements de Toulouse (Comue); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse (EPE); CHU de Toulouse; Memorial Sloan Kettering Cancer Center; Agios Pharmaceuticals; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Hong Kong
  摘要：In human acute myeloid leukemia (AML), mutations of isocitrate dehydrogenase-1 (IDH1) often co-occur with NPM1 mutations, and less frequently with FLT3 mutations. To investigate whether the effects of IDH1 mutation differ according to the specific co-occurring mutation, we generated two strains of double knock-in mutant mice. Idh1R132H combined with Npm1c induced overt AML, whereas Idh1R132H plus Flt3ITD resulted in Flt3ITD-driven myelo-or lymphoproliferation that was minimally affected by Idh...
• Controlling impact mitigation via Bouligand nanostructures AI翻译
  作者：Lee, Sujin R.; Evans, Katherine M.; Woodcock, Jeremiah W.; Obrzut, Jan; Huang, Liping; Soles, Christopher L.; Chan, Edwin P.
  作者单位：National Institute of Standards & Technology (NIST) - USA; Rensselaer Polytechnic Institute
  摘要：Critical to their survival, natural organisms have developed exoskeletons that can withstand and inflict damage over their lifetime. The Bouligand structure of the exoskeleton plays a key role in toughness and damage resistance under external impacts. Numerous studies have investigated the morphology of Bouligands and their mechanical properties, yet understanding their structure-function relationship remains challenging due to the complex mechanical responses of biological materials and the l...
• A prolactin- targeting antibody to prevent stress- induced peripheral nociceptor sensitization and female postoperative pain AI翻译
  作者：Stratton, Harrison J.; Dolatyari, Mahdi; Kopruszinski, Carol; Ghetti, Andre; Maciuba, Stephanie; Bowden, Greg; Riviere, Pierre; Barber, Kara; Dodick, David W.; Edorh, Edel; Dumaire, Nicolas; Moutal, Aubin; Navratilova, Edita; Porreca, Frank
  作者单位：University of Arizona; University of Arizona Health Sciences; Saint Louis University
  摘要：Scheduled surgeries elicit stress in many patients. Levels of preoperative stress, anxiety, and female gender are known risk factors for increased and prolonged postoperative pain. The mechanisms by which psychological stress increases postoperative pain, especially in women, remain unknown. We hypothesized that stress amplifies postoperative pain by sensitizing dorsal root ganglion (DRG) nociceptors. Prolactin (PRL) is a female-predominant neurohormone that is controlled by estrogen and stres...
• Diversity statistics of onomastic data reveal social patterns in Hebrew Kingdoms of the Iron Age AI翻译
  作者：Vishne, Ariel; Golub, Mitka R.; Piasetzky, Eli; Finkelstein, Israel; Sober, Barak
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Tel Aviv University; University of Haifa; Hebrew University of Jerusalem
  摘要：The distribution of personal names provides unique, yet often overlooked, insight into modern and historical societies. This study employs diversity statistics-commonly used in ecology-to analyze onomastic data from Iron Age II archaeological excavations in the Southern Levant (950-586 BCE). Our findings reveal higher onomastic diversity in the Kingdom of Israel compared to Judah, suggesting a more cosmopolitan society. We also observe a decrease in name diversity in Judah over time, potential...
• Theory and observations of the interaction between magnetohydrodynamic waves and shocks AI翻译
  作者：Zhao, Lingling; Zhu, Xingyu; Silwal, Ashok; Zank, Gary P.; Pitna, Alexander
  作者单位：University of Alabama System; University of Alabama Huntsville; University of Alabama System; University of Alabama Huntsville; Charles University Prague
  摘要：The interaction between interplanetary shocks or planetary bow shock and upstream magnetohydrodynamics (MHD) waves (hereafter referred to as wave-shock interactions) is of fundamental importance to plasma physics. Linear waves and shocks, which are supported by MHD framework, are ubiquitous in almost all plasma environments. A thorough understanding of the interaction between linear waves and shocks is useful not only for heliophysics and astrophysics but also for other applications such as in...
• Hygrometrically controlled programmed cell death drives anther opening and pollen release AI翻译
  作者：Kampova, Anna; Nowack, Moritz K.; Fendrych, Matyas; Vosolsobe, Stanislav
  作者单位：Charles University Prague; Ghent University; Ghent University; Flanders Institute for Biotechnology (VIB)
  摘要：Anther dehiscence is the process that facilitates pollen release from mature anthers in flowering plants. Despite its crucial importance to reproduction, the underlying developmental mechanism and its integration with environmental cues remain poorly understood. Establishing noninvasive, controlled humidity treatments ofArabidopsis thaliana flowers, we show here that high humidity prevents anthers from opening. Manipulation of stomatal densities alters dehiscence dynamics, suggesting a contrib...
• The fate of South America's endemic mammalian fauna in response to the most dramatic Cenozoic climate disruption AI翻译
  作者：Buffan, Lucas; Condamine, Fabien L.; Stutz, Narla S.; Pujos, Francois; Antoine, Pierre - Olivier; Marivaux, Laurent
  作者单位：Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
  摘要：Around 34 Mya, the Eocene-Oligocene transition (EOT) marked the most dramatic global climatic cooling of the Cenozoic. On a planetary scale, paleontological evidence suggests that this transition was associated with major faunal turnovers, sometimes even regarded as a mass extinction crisis. In South America, there is no consensus on the response of the endemic mammals to this transition. Here, using a vetted fossil dataset and cutting-edge Bayesian methods, we analyzed the dynamics of South A...
• Most totally real fields do not have universal forms or the Northcott property AI翻译
  作者：Daans, Nicolas; Kala, Vitezslav; Man, Siu Hang; Widmer, Martin; Yatsyna, Pavlo
  作者单位：Charles University Prague; KU Leuven; Graz University of Technology
  摘要：We show that, in the space of all totally real fields equipped with the constructible topology, the set of fields that admit a universal quadratic form, or have the Northcott property, is meager. The main tool is a theorem on the number of square classes of totally positive units represented by a quadratic lattice of a given rank.