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作者：Matadamas-Gomora, Diego; Nesbitt, Jason; Tapia, Rodolfo Aguilar; Lujan, Leonardo Lopez; Sjodahl, Julia; Murakami, Tatsuya; Pastrana, Alejandro
作者单位：Tulane University
摘要：This study presents the results of geochemical compositional analysis through portable X-ray fluorescence of 788 artifacts from the Templo Mayor in Mexico City. The results reveal that the Mexica (Aztecs) preferred green obsidian from Sierra de Pachuca. However, a diachronic analysis (c. 1375-1520 CE) demonstrated that they continuously consumed obsidian from seven additional sources with some temporal variations related to the sociopolitical transformations of the empire. In the early phases,...
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作者：Stupacher, Jan; Matarrelli, Benedetta; Cozzoli, Danilo; Ventura, Mario; Montinaro, Francesco; de Gennaro, Luciana; Vuust, Peter; Brattico, Elvira
作者单位：Aarhus University; Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; University of Tartu
摘要：Substance use disorders disrupt the dopaminergic system of the human brain, which plays a central role in movement and reward processing, altering perception, and cognition. The pleasurable urge to move to music, known as groove, relies on dopamine for reward, anticipation, beat perception, and motor system activity. Using a well- established paradigm, which shows an inverted- U relationship between groove and musical complexity, we investigated how dopamine downregulation from long- term coca...
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作者：Wang, Gaojianyong; Korody, Marisa L.; Braendl, Bjoern; Hernandez-Toro, Camilo Jose; Rohrandt, Christian; Hong, Karl; Pang, Andy Wing Chun; Lee, Joyce; Migliorelli, Giovanna; Stanke, Mario; Ford, Sarah M.; Pollmann, Iris; Houck, Marlys L.; Lewin, Harris A.; Lear, Teri L.; Ryder, Oliver A.; Meissner, Alexander; Loring, Jeanne F.; Mueller, Franz-Josef
作者单位：Max Planck Society; University of Kiel; University of Kiel; Schleswig Holstein University Hospital; University of Kiel; Universitat Greifswald; Universitat Greifswald; University of California System; University of California Santa Cruz; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; University of Kentucky; Scripps Research Institute
摘要：The northern white rhinoceros (NWR; Ceratotherium simum cottoni) is functionally extinct, with only two nonreproductive females alive. Efforts to rescue the NWR from its inevitable demise have inspired the exploration of unconventional conservation methods, including the development of induced pluripotent stem cells (iPSCs) for the in vitro generation of artificial gametes. The integrity of iPSC genomes is critical for in vitro gametogenesis to be used for assisted reproductive technologies us...
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作者：Mannino, Robert G.; Sullivan, Julie; Frediani, Jennifer K.; George, Paul; Whitson, Jeremy; Tumlin, James; Lyon, L. Andrew; Tyburski, Erika A.; Lam, Wilbur A.
作者单位：Emory University; Emory University; Children's Healthcare of Atlanta (CHOA); Chapman University System; Chapman University; Chapman University System; Chapman University; University System of Georgia; Georgia Institute of Technology; Emory University
摘要：Anemia, characterized by low blood hemoglobin (Hgb) levels, afflicts >2 billion individuals worldwide. Here, we report real-world data generated by a smartphone app that noninvasively screens for anemia using only fingernail selfies. App data for anemia screening were obtained from >1.4 million uses across the United States enabling geographic mapping of Hgb levels. Of those, 9,061 users also self-reported complete blood count Hgb levels for comparison, resulting in accuracy and performance th...
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作者：Wu, Quran; Gregory, Jonathan M.; Zanna, Laure; Khatiwala, Samar; Cazenave, Anny
作者单位：University of Reading; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; Met Office - UK; Hadley Centre; New York University; New York University; Waseda University
摘要：The global energy budget is fundamental for understanding climate change. It states that the top-of-atmosphere imbalance between radiative forcing (which drives climate change) and radiative response (which resists the forcing) equals energy storage in Earth's heat reservoirs (i.e. the ocean, atmosphere, land, and cryosphere). About 90% of Earth's energy imbalance is stored as heat content in the ocean interior, which is poorly sampled before 1960. Here, we reconstruct Earth's energy imbalance...
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作者：McQuillen, Patrick S.; Harasymiw, Lauren
作者单位：University of California System; University of California San Francisco
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作者：Tao, Ruiyan; Trivedi, Ira; Trimborn, Laura; Ponnu, Jathish; Toth, Blanka Violetta; Hoecker, Ute
作者单位：University of Cologne; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Helmholtz Association; Karlsruhe Institute of Technology
摘要：COP1 is a conserved ubiquitin ligase found in plants and animals. In plants, COP1 acts together with SPA proteins to suppress light signaling in darkness by promoting the degradation of transcription factors involved in photomorphogenesis. Substrates of this ubiquitin ligase share a Valine-Proline (VP) motif that interacts with the WD-repeat domain of COP1 in plants and humans. Here, we have identified the transcription factor TCP3 as a noncanonical substrate of COP1/SPA that lacks a VP motif....
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作者：Meng, Xue; Li, Yang; Xu, Jiuyin; Wu, Kai; Hu, Wen; Wu, Canrong; Xu, H. Eric; Xu, Youwei
作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; ShanghaiTech University; Shanghai Jiao Tong University; Guangzhou Medical University
摘要：Prostaglandin E2 (PGE2) mediates diverse physiological processes through four G protein-coupled receptor subtypes (EP1-EP4). While structures of EP2, EP3, and EP4 have been determined, the structural basis for PGE2 recognition and activation of the EP1 receptor subtype has remained elusive due to its inherent instability. Here, we present the cryoelectron microscopy structure of the human EP1 receptor in complex with PGE2 and heterotrimeric Gq protein at 2.55 & Aring; resolution, completing th...
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作者：Petrovic, Ivana; Tatli, Meltem; Desai, Samit; Grahl, Anne; Ni, Dongchun; Stahlberg, Henning; Spang, Anne; Grzesiek, Stephan; Abiko, Layara Akemi
作者单位：University of Basel; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Lausanne
摘要：Only two nonvisual arrestins recognize many hundreds of different, intracellularly phosphorylated G protein-coupled receptors (GPCRs). Due to the highly dynamic nature of GPCR center dot arrestin complexes, the critical determinants of GPCR-arrestin recognition have remained largely unclear. We show here that arrestin2 recruitment to the R1-adrenergic receptor (R1AR) can be induced by an arrestin-activating phosphopeptide that is not covalently linked to the receptor and that the recruitment i...
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作者：Yan, Xingchi; Yu, Polly Y.; Srinivasan, Arvind; Rehman, Sohaib Abdul; Sreenivas, Surabhi Kottigegollahalli; Conway, Jeremy B.; Prigozhin, Maxim B.
作者单位：Harvard University; Harvard University; Harvard University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Intermolecular interactions underlie all cellular functions, yet visualizing these interactions at the single-molecule level remains challenging. Single-molecule localization microscopy (SMLM) offers a potential solution. Given a nanoscale map of two putative interaction partners, it should be possible to assign molecules either to the class of coupled pairs or to the class of noncoupled bystanders. Here, we developed a probabilistic algorithm that allows accurate determination of both the abs...
