-
作者：Jiang, Mengting; Xu, Youwei; Luan, Xiaodong; Wu, Kai; Li, Zhen; Xu, H. Eric; Zhang, Shuyang; Jiang, Yi; Yin, Wanchao
-
作者：Barrera, Francisco N.
作者单位：University of Tennessee System; University of Tennessee Knoxville
-
作者：Borovska, Petra; de Haas, Benjamin
-
作者：Garcia, Julian; Traulsen, Arne
作者单位：Monash University; Max Planck Society
摘要：Evolutionary game theory (EGT) has been pivotal in the study of cooperation, offering formal models that account for how cooperation may arise in groups of selfish, but simple agents. This is done by inspecting the complex dynamics arising from simple interactions between a few strategies in a large population. As such, the strategies at stake are typically hand-picked by the modeler, resulting in a system with many more individuals in the population than strategies available to them. In the p...
-
作者：Jeong, Dawon; Park, Seo Hyeong; Kim, Jiwon; Kim, Hyeyoon; Jang, Yejin; Koh, Jaemoon; Jeon, Yoon Kyung; Tasaki, Takafumi; Kwon, Yong Tae; Han, Dohyun; Cho, Sung-Yup; Lee, Min Jae
作者单位：Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Seoul National University (SNU); Kanazawa Medical University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; Seoul National University (SNU)
摘要：Cellular senescence, an irreversible cell cycle arrest, plays a pivotal role in development, aging, and tumor suppression. However, the fundamental pathway coordinating senescence and neoplastic transformation remains unclear. Here, we describe the tumorigenic involvement of ubiquitin protein ligase E3 component n-recognin 4 (UBR4), an E3 ubiquitin ligase of the N-degron pathway, in lung adenocarcinoma (LUAD). Public genome databases revealed high UBR4 expression in LUAD patients, associated w...
-
作者：Liu, Xingyu; Yi, Li; Lin, Zongtao; Chen, Siyu; Wang, Shunyang; Sheng, Ying; Lebrilla, Carlito B.; Garcia, Benjamin A.; Xie, Yixuan
作者单位：Fudan University; Fudan University; Washington University (WUSTL); University of California System; University of California Davis; University of California System; University of California Davis
摘要：Protein-protein interactions (PPIs) are crucial for comprehending the molecular mechanisms and signaling pathways underlying diverse biological processes and disease progression. However, investigating PPIs involving membrane proteins is challenging due to the complexity and heterogeneity of glycosylation. To tackle this challenge, we developed an approach termed glycan-dependent affinity purification coupled with mass spectrometry (GAP-MS), specifically designed to characterize changes in gly...
-
作者：Mann, Adam
-
作者：Muramatsu, David; Weyer, Henrik; Gartner, Florian M.; Frey, Erwin
作者单位：University of Munich; University of Munich
摘要：The thymus is one of the most important organs of the immune system. It is responsible for both the production of T cells and the prevention of their autoimmunity. It comprises two types of tissue: The cortex, where nascent T cells (thymocytes) are generated; and the medulla, embedded within the cortex, where autoreactive thymocytes are eliminated through negative selection. In mice, the medulla exhibits a complex, convoluted morphology, which has raised the question of whether its form impact...
-
作者：Ren, Xiaojun; Sui, Xiao; Karton, Amir; Nishina, Yuta; Lin, Tongxi; Asanoma, Daisuke; Owens, Llewellyn; Ji, Dali; Wen, Xinyue; Quintano, Vanesa; Tripathi, Komal; Pant, Kamal K.; Dai, Liming; Andreeva, Daria, V; Foller, Tobias; Novoselov, Kostya S.; Joshi, Rakesh
作者单位：University of New South Wales Sydney; Harbin Institute of Technology; University of New England; Okayama University; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore; Barcelona Institute of Science & Technology; Consejo Superior de Investigaciones Cientificas (CSIC); Catalan Institute of Nanoscience & Nanotechnology (ICN2); Barcelona Institute of Science & Technology; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Roorkee; University of New South Wales Sydney; National University of Singapore
摘要：Water molecules at the solid-liquid interface display intricate behaviors sensitive to small changes. The presence of different interfacial components, such as cations or functional groups, shapes the physical and chemical properties of the hydrogen-bond network. Understanding such interfacial hydrogen-bond networks is essential for a large range of applications and scientific questions. To probe the interfacial hydrogen-bond network, atmospheric water capture is a powerful tool. Here, we expe...
-
作者：Fan, Zhao; Rawat, Deepak; Zarzycki, Piotr; Whittaker, Michael L.; Asta, Mark
作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Despite over a century of studies, fundamental questions remain about the processes governing crystal nucleation from melts or solutions. Research over the past three decades has presented mounting evidence for kinetic pathways of crystal nucleation that are more complex than envisioned by the simplest forms of classical theory. Such observations have been presented for colloidal and elemental systems with covalent and metallic bonding. Despite the technological and geochemical importance of m...
