28期

最新文章

• Competition for Hfq drives kinetic selection of mRNA targets by Escherichia coli small noncoding RNAs AI翻译
  作者：Roca, Jorjethe; Chen, Yi- Lan; Woodson, Sarah A.
  作者单位：Johns Hopkins University; Roche Holding; Roche Holding USA
  摘要：Small noncoding RNAs (sRNAs) regulate gene expression in Escherichia coli bacteria in response to diverse stimuli in the environment and the host. Most sRNAs regulate mRNA expression by directly base pairing with complementary sites in the target mRNA with the help of the chaperone protein Hfq. sRNAs and Hfq must rapidly search hundreds of candidate mRNAs for matched (cognate) targets while discriminating against noncognate targets. Here, we use single-molecule fluorescence microscopy to direc...
• Oxidative stress is a shared characteristic of ME/CFS and Long COVID AI翻译
  作者：Shankar, Vishnu; Wilhelmy, Julie; Curtis, Ellis J.; Michael, Basil; Cervantes, Layla; Mallajosyula, Vamsee; Davis, Ronald W.; Snyder, Michael; Younis, Shady; Robinson, William H.; Shankar, Sadasivan; Mischel, Paul S.; Bonilla, Hector; Davis, Mark M.
  作者单位：Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; University of California System; University of California San Diego; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Geriatric Research Education & Clinical Center; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Stanford University; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Howard Hughes Medical Institute
  摘要：Over 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition marked by fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS). With no clinically approved treatments or reliable diagnostic markers, there is an urgent need to define the molecular underpinnings of these conditions. By studying bioenergetic characteristics of peripheral blood lymphocytes in 25 healthy controls, ...
• Reply to Pang et al.: Generalizable ability to track beliefs could be the most parsimonious explanation AI翻译
  作者：Kosinski, Michal
  作者单位：Stanford University
• Including the gender dimension of migration is essential to avoid systematic bias in migration predictions AI翻译
  作者：Anastasiadou, Athina; Zagheni, Emilio; de Valk, Helga A. G.
  作者单位：Max Planck Society; Royal Netherlands Academy of Arts & Sciences; University of Groningen; Netherlands Interdisciplinary Demographic Institute (NIDI-KNAW)
  摘要：This study examines the theoretical and methodological limitations of migration research in understanding gender-specific trends of migration. In particular, theory-driven methods suffer from the gender blindness of migration theories, while data-driven methods suffer from the scarcity of gender disaggregated migration data. This research aims to evaluate how these dual limitations affect the accuracy of commonly used migration prediction models. By analyzing migration flows disaggregated by g...
• Osteoinductive low- dose 3D porous calcium phosphate graphene oxide-integrated matrices enhance osteogenesis and mechanical properties AI翻译
  作者：Hosseini, Fatemeh S.; Whitfield, Taraje; Orlando, Jason D.; Deng, Chenyun; Abedini, Amir A.; Argyrou, Chrysoula; Kan, Ho - Man; Ghosh, Debolina; Maye, Peter F.; Lo, Kevin W. - H.; Nair, LakshmiS.; Sydlik, Stefanie A.; Laurencin, Cato T.
  作者单位：University of Connecticut; University of Connecticut; Carnegie Mellon University; Carnegie Mellon University; University of Connecticut; University of Connecticut; University of Connecticut; University of Connecticut
  摘要：Bone regeneration continues to be a challenge due to the complex nature of the tissue. Identifying new materials that stimulate regeneration while providing mechanical properties is an active area of research. One class of promising material in bone regeneration is graphene and its derivatives including graphene oxide (GO), the oxidized form of graphene. Recently, calcium phosphate graphene (CaPG), synthesized from GO, has been proven to have osteoinductive properties in vivo. However, CaPG is...
• Unveiling the charge transport blockade in the D2 branch of the photosystem II reaction center AI翻译
  作者：Mandal, Aditya Kumar; Basera, Shubham; Goddard III, William A.; Maiti, Prabal K.
  作者单位：Indian Institute of Science (IISC) - Bangalore; California Institute of Technology
  摘要：Photosynthesis, the fundamental process sustaining life on Earth, depends on the photosystem II (PSII) reaction center's ability to initiate the charge transport process. In this study, we have investigated this charge transport process with a focus on the dissimilarity between the two branches of the PSII reaction center, D1 and D2. Utilizing Marcus theory, we have calculated the reorganization energies and activation barriers for all the key steps involved in the charge transport process. Ou...
• Political and biological reality checks AI翻译
  作者：Berenbaum, May R.
• Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Ighm) as a tissue-level aging biomarker AI翻译
  作者：Yin, Fan-Qian; Wang, Xia-Yan; Li, Yong-Xuan; Li, Kai-Jing; Ma, Si-Yu; Lv, Meng-Jiao; Liu, Zhen-Hua; Zhong, Wei-Xia; Liu, Yan; Tang, Chuan-Fang; Liu, Hong-Shi; Li, Yuze; Xiao, Fu-Hui; Kong, Qing-Peng
  作者单位：Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Ningbo University; Chinese Academy of Sciences
  摘要：Identifying aging-associated biomarkers applicable for multiple tissues is challenging but crucial for assessing tissue aging. Here, we obtained and analyzed 456 transcriptomes on 17 organs from 30 C57BL/6 J mice with different ages, revealing the consistently upregulated mRNAs of Ighm, Cob, and Ccl8 in most aged organs. This finding received support from independent transcriptomic and proteomic datasets and was further validated through western blot, enzyme-linked immunosorbent assay (ELISA),...
• TaHSP18.6 and TaSRT1 interact to confer resistance to Fusarium crown rot by regulating the auxin content in common wheat AI翻译
  作者：Zhang, Ning; Liu, Lu; Li, Songgang; Wei, Yuhui; Ren, Wanting; Li, Mengyao; Zhao, Simin; Sun, Zhipeng; Yang, Xia; Ren, Yan; Yang, Mei; He, Guangming; Deng, Xing Wang; Chen, Feng
  作者单位：Henan Agricultural University; Peking University; Peking University; Peking University
  摘要：Fusarium crown rot (FCR) is one of the most serious soil-borne diseases in common wheat and has caused major wheat yield losses worldwide. Here, we identified an 18.6 kDa heat shock protein gene (TaHSP18.6) through combining a transcriptome analysis and a genome-wide association study. We verified the positive role of TaHSP18.6 in regulating wheat FCR resistance using ethyl methanesulfonate (EMS) mutants and genetic transformation. Next, we screened a lysine deacetylase sirtuin-like (TaSRT1) t...
• The WWP1-JARID1B axis sustains acute myeloid leukemia chemoresistance AI翻译
  作者：Fierro, Claudia; Giovannini, Sara; Moriconi, Valeria; Fiorilli, Claudia; Panatta, Emanuele; Frezza, Valentina; Corigliano, Federica; Pecorari, Rosalba; Li, Yanan; Zhou, Ji; Delvecchio, Vincenza Simona; Smirnov, Artem; Manteiga, Jose Manuel Garcia; Brendolan, Andrea; Zhang, Jinping; Shi, Yufang; Amelio, Ivano; Candi, Eleonora; Melino, Gerry; Bernassola, Francesca
  作者单位：University of Rome Tor Vergata; IRCCS Istituto Dermopatico dell'Immacolata (IDI); Soochow University - China; Soochow University - China; Vita-Salute San Raffaele University; IRCCS Ca Granda Ospedale Maggiore Policlinico; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS Ca Granda Ospedale Maggiore Policlinico; IRCCS Ospedale San Raffaele; University of Konstanz
  摘要：To uncover substrates mediating the oncogenic activity of WWP1 in acute myeloid leukemia (AML), we performed a proteomic analysis that identified the histone demethylase KDM5B/JARID1B as a candidate target. Of note, JARID1B is indispensable for efficient recruitment of several DNA damage repair factors and for damage resolution, thus negatively influencing the sensitivity of cancer cells to chemo-and radiation therapies. Validation of JARID1B as a substrate of WWP1 revealed a positive regulati...