-
作者：Stephens, Dylon R.; Fung, Ho Yee Joyce; Han, Yan; Liang, Jue; Chen, Zhe; Ready, Joseph; Collins, James J.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Schistosomes are parasitic flatworms that infect more than 200 million people globally. However, there is a shortage of molecular tools that enable the discovery of potential drug targets within schistosomes. Thus, praziquantel has remained the frontline treatment for schistosomiasis despite known liabilities. Here, we have conducted a genome- wide study in Schistosoma mansoni using the human druggable genome as a bioinformatic template to identify essential genes within schistosomes bearing s...
-
作者：Jankovic, Matija; Kang, Seungmin; Bhattacharya, Sarnab; Kashanchi, Jordon; Wang, Jieting; Deoli, Kanika; Huang, Tianda; Johnson, Alex; Ambani, Karina; Kim, Sangjun; Wang, Pulin; Coyle, Edward; Lu, Nanshu
-
作者：Ryan, Allison T.; Kim, Minsoo
作者单位：University of Rochester
-
作者：Wang, Junli; Sun, Xinhua; Xiong, Fei; Lapin, Dmitry; Lee, Tak; Martin-Ramirez, Sergio; Prakken, Anna; Shen, Qiaochu; Bautor, Jaqueline; Maekawa, Takaki; Parker, Jane E.
作者单位：Max Planck Society; University of Cologne; Max Planck Society; Southwest University - China; Utrecht University; Wageningen University & Research; University of Michigan System; University of Michigan
摘要：The plant immune system utilizes nucleotide-binding/leucine-rich repeat (NLR) proteins to detect pathogen virulence factors (effectors) inside host cells and transduce recognition to rapid defense. In dicotyledenous plants, pathogen activated Toll-like/interleukin-1 receptor-containing NLRs (TNLs) establish a signaling network of enhanced susceptibility 1 (EDS1)-family dimers with RPW8-type coiled-coil (CCR) domain NLRs (RNLs) to stimulate transcriptional reprogramming leading to host cell dea...
-
作者：Du, Samuel W.; Palczewska, Grazyna; Dong, Zhiqian; Lauterborn, Julie C.; Kaipa, Balasankara Reddy; Yan, Alexander L.; Holubowicz, Rafa; Ha, Siyoung; Chen, Paul Z.; Gall, Christine M.; Zode, Gulab; Liu, David R.; Palczewski, Krzysztof
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Howard Hughes Medical Institute; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：In vivo genome editing has the potential to address many inherited and environmental disorders. However, a major hurdle for the clinical translation of genome editing is safe, efficient delivery to disease-relevant tissues. A modality-agnostic reporter animal model that facilitates rapid, precise, and quantifiable assessment of functional delivery and editing could greatly enhance the evaluation and translation of delivery technologies. Here, we present the development of the tdTomato in vivo ...
-
作者：Goebel, Erich J.; Aykul, Senem; Hom, Warren W.; Saotome, Kei; Economides, Aris N.; Franklin, Matthew C.; Idone, Vincent J.
作者单位：Regeneron; Regeneron
摘要：Ligands in the transforming growth factor beta (TGF-beta) family [activins, Bone Morphogenetic Proteins (BMPs), and TGF-beta s] signal by bringing together two type I and two type II receptors. Activin receptor-like kinase-2 (ALK2) is the only type I receptor among the seven TGF-beta type I receptors that interacts with both activin and BMP ligands. With BMPs, ALK2 acts as a signaling receptor to activate small mothers against decapentaplegic 1 (SMAD1)/5/8 signaling. Alternatively, with activi...
-
作者：Jung, Ji - Ung; Stippec, Steve; Cobb, Melanie H.
作者单位：University of Texas System; University of Texas Southwestern Medical Center
摘要：With No lysine (K) 1 (WNK1) is essential for ion and volume homeostasis, sensing osmotic stress and activating pathways that regulate ion transport. Its response to osmotic stress shares similarities with the function of the mechanosensitive ion channel Piezo1. In this study, we show that Yoda1, a Piezo1 agonist, activates WNK1 downstream kinase targets oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related serine, proline-, and alanine-rich kinase (SPAK) in endothelial cells within minut...
-
作者：Sebaaly, Angelo P.; van Rijn, Frank; Hanna, Khalil; Boily, Jean - Francois
作者单位：Umea University; Universite de Rennes; Ecole Nationale Superieure de Chimie de Rennes (ENSCR); Centre National de la Recherche Scientifique (CNRS)
摘要：Ice often mediates unexpected reactions in the Cryosphere, acting as a fascinating geochemical reactor. Mineral-organic interactions in frozen environments, such as soils and permafrost, are crucial for explaining the flux of soluble iron during melting events, yet the mechanisms remain misunderstood. This study elucidates the unique roles of freezing in the dissolution of iron oxyhydroxide nanoparticles (alpha-FeOOH) by oxalate, a low molecular weight dicarboxylate, under acidic conditions. F...
-
作者：Bubphamanee, Kunmanee; Kipp, Michael A.; Meixnerova, Jana; Stueken, Eva E.; Ivany, Linda C.; Bartholomew, Alexander J.; Algeo, Thomas J.; Brocks, Jochen J.; Dahl, Tais W.; Kinsley, Jordan; Tissot, Francois L. H.; Buick, Roger
作者单位：University of Washington; University of Washington Seattle; National Aeronautics & Space Administration (NASA); California Institute of Technology; Duke University; University of St Andrews; Syracuse University; State University of New York (SUNY) System; SUNY New Paltz; University System of Ohio; University of Cincinnati; China University of Geosciences; Chengdu University of Technology; Australian National University; University of Copenhagen
摘要：The oxygenation history of Earth's surface environments has had a profound influence on the ecology and evolution of metazoan life. It was traditionally thought that the Neoproterozoic Oxygenation Event enabled the origin of animals in marine environments, followed by their persistence in aerobic marine habitats ever since. However, recent studies of redox proxies (e.g., Fe, Mo, Ce, I) have suggested that low dissolved oxygen levels persisted in the deep ocean until the Late Devonian, when the...
-
作者：Lopez- Cubillos, Sofia; Mason, Natalie; Wintle, Brendan; Pacheco, Pablo; Ochoa-Quintero, Jose Manuel; Nascimento, Nathalia; Torres, Bolier; Runting, Rebecca K.
作者单位：University of Melbourne; University of Melbourne; World Wildlife Fund; Universidade Federal de Mato Grosso do Sul; Universidade de Sao Paulo
