35期

最新文章

• Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants AI翻译
  作者：Wang, Siling; Sun, Hui; Wang, Yizhen; Wang, Zikang; Yuan, Lunzhi; Guo, Huilin; Gao, Jiahua; Lan, Miaolin; Wu, Yangtao; Shang, Huixian; Chen, Xiuting; Chen, Zheng; Hu, Jiayi; Tang, Zimin; Wen, Guiping; Ying, Dong; Liu, Chang; Jiang, Yanan; Su, Jinfu; Lin, Min; Wu, Ting; Li, Shaowei; Zhang, Tianying; Zhang, Jun; Guan, Yi; Yuan, Quan; Xia, Ningshao; Zheng, Qingbing; Zhang, Yali; Zheng, Zizheng
  作者单位：Xiamen University; Xiamen University; Xiamen University; University of Hong Kong; Shantou University; University of Hong Kong; Shantou University; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) bivalent vaccines show potential against variants but lack a full understanding of the immunological mechanisms that drive broadly neutralizing antibodies (bnAbs). This study explored the immunogenicity of a bivalent vaccine in rhesus macaques, containing spike (S) proteins from the prototype (Sprototype) and chimeric S protein (S1628x). The vaccine induced bnAbs against multiple variants, including challenging subvariants like EG.1, ...
• Parallel trade-offs in human cognition and neural networks: The dynamic interplay between in-context and in-weight learning AI翻译
  作者：Russin, Jacob; Pavlick, Ellie; Frank, Michael J.
  作者单位：Brown University; Brown University; Brown University
  摘要：Human learning embodies a striking duality: Sometimes, we can rapidly infer and compose logical rules, benefiting from structured curricula (e.g., in formal education), while other times, we rely on an incremental approach or trial-and-error, learning better from curricula that are randomly interleaved. Influential psychological theories explain this seemingly conflicting behavioral evidence by positing two qualitatively different learning systems-one for rapid, rule-based inferences (e.g., in...
• STIM1 transmembrane helix dimerization captured by AI-guided transition path sampling AI翻译
  作者：Horvath, Ferdinand; Jung, Hendrik; Grabmayr, Herwig; Fahrner, Marc; Romanin, Christoph; Hummer, Gerhard
  作者单位：Johannes Kepler University Linz; Max Planck Society; Johannes Kepler University Linz; Goethe University Frankfurt; Institute of Science & Technology - Austria
  摘要：Stromal interaction molecule 1 (STIM1) is a Ca2+-sensing protein in the endoplasmic reticulum (ER) membrane. The depletion of ER Ca2+ stores induces a large conformational transition of the cytosolic STIM1 C-terminus, initiated by the dimerization of the transmembrane (TM) domain. We use the AI-guided transition path sampling algorithm aimmd to extensively sample the dimerization of STIM1-TM helices in an ER-mimicking lipid bilayer. In nearly 0.5 ms of all-atom molecular dynamics simulations w...
• Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice AI翻译
  作者：Keck, Carl H. C.; Schmidt, Elizabeth L.; Roth, Richard H.; Floyd, Brendan M.; Tsai, Andy P.; Garcia, Hassler B.; Cui, Miao; Chen, Xiaoyu; Wang, Chonghe; Park, Andrew; Zhao, Su; Liao, Pinyu A.; Casey, Kerriann M.; Reineking, Wencke; Cai, Sa; Zhang, Ling - Yi; Yang, Qianru; Yuan, Lei; Baghdasaryan, Ani; Lopez, Eduardo R.; Cooper, Lauren; Cui, Han; Esquivel, Daniel; Brinson, Kenneth; Chen, Xiaoke; Wyss-Coray, Tony; Coleman, Todd P.; Brongersma, Mark L.; Bertozzi, Carolyn R.; Wang, Gordon X.; Ding, Jun B.; Hong, Guosong
  作者单位：Stanford University; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford University; Stanford Medicine
  摘要：Light scattering in biological tissue presents a significant challenge for deep in vivo imaging. Our previous work demonstrated the ability to achieve optical transparency in live mice using intensely absorbing dye molecules, which created transparency in the red spectrum while blocking shorter- wavelength photons. In this paper, we extend this capability to achieve optical transparency across the entire visible spectrum by employing molecules with strong absorption in the ultraviolet spectrum...
• Early-life infectious disease exposure, the hygiene hypothesis, and lifespan: Evidence from hookworm disease AI翻译
  作者：Lawton, Ralph
  作者单位：Harvard University
  摘要：Exposure to infectious disease in early life may have long-term ramifications for health and lifespan. However, reducing pathogen exposure may not be uniformly beneficial. The rise of modern sanitation and reduction of infectious diseases has been implicated in increasing levels of allergy and immune dysregulation: termed, the hygiene hypothesis. This study leverages quasi-experimental variation from combining precampaign hookworm exposure with the Rockefeller Sanitary Commission's deworming c...
• Loss of ICOSL expression in the progression to cervical carcinoma AI翻译
  作者：Nuovo, Gerard J.; Tili, Esmerina; Croce, Carlo M.
  作者单位：University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; University System of Ohio; Ohio State University
  摘要：Human papillomavirus (HPV)-related lesions contain types with benign outcomes and those with a risk of progression to cancer. We addressed the role of immune surveillance in 76 cervical biopsies (normal = 23, HPV+ benign = 16, HPV+ precancer = 37) by studying the infiltration of cytotoxic T cells and the expression of the immune modulators PDL1, ICOSL, and miR-155 and compared the data to 101 cervical squamous cell carcinomas. In the normal cervix, ICOSL expression was restricted to the endoce...
• Impact of women's political empowerment through gender quotas on improved drinking water access in Africa (vol 122 , e2511977122, 2025) AI翻译
  作者：An, Jiafu; Wang, Tenghui; Chen, Bin; Gong, Peng; Lin, Chen; Stenseth, Nils Chr.
  作者单位：University of Hong Kong; Lingnan University; University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; Tsinghua University; University of Oslo; University of Oslo
• Interfacial electroneutrality controls transport of asymmetric salts through charge-patterned mosaic membranes AI翻译
  作者：Gao, Feng; Hoffman, John R.; Xu, Jialing; Ievlev, Anton, V; Whitmer, Jonathan K.; Phillip, William A.
  作者单位：University of Notre Dame; United States Department of Energy (DOE); Oak Ridge National Laboratory; Center for Nanophase Materials Sciences
  摘要：Membranes that selectively enhance target solute permeation while rejecting competing species are essential for precision separations. This study introduces charge-patterned mosaic membranes (CMMs) that selectively transport divalent asymmetric salts by leveraging a net-neutral membrane-solution interface. This mechanism, dictated by the charge ratio of positive and negative domains on the membrane surface and the balance of cations and anions in the salt, is supported by analytical, numerical...
• BIK polymorphism and proteasome regulation unveil host risk factor for severe influenza (vol 122, e2424367122, 2025) AI翻译
  作者：Soni, Sourabh; Yildiz, Soner; Allen, Emma Kaitlynn; Petersen, Hans; Peeples, Mark; El Zahed, Sara; Rosas, Lorena; Anang, Vandana; Antonescu, Laura; Nho, Richard Seonghun; Mora, Ana Lucia; Horowitz, Jeffrey Craig; Rojas, Mauricio; Medina, Rafael Andres; Thomas, Paul Glyndwr; Garcia-Sastre, Adolfo; Tesfaigzi, Yohannes; Mebratu, Yohannes Afework
• Local c- di- GMP signaling, triggered by cross- regulation of cAMP- CRP and c- di- GMP, controls biofilm formation under nutrient limitation AI翻译
  作者：Sun, Di; Liu, Xiaobo; Zhang, Ying; Shi, Rui; Ru, Yunrui; Zhou, Xuge; Chen, Ying; Yang, Jing; Liu, Jiawen; Zhu, Jingrong; Liu, Cong; Liu, Weijie
  作者单位：Jiangsu Normal University; Nanjing University of Science & Technology; Beijing Institute of Technology
  摘要：Bacteria have several nucleotide second messengers, most of which act as global regulators to control a wide range of bacterial physiological processes. Studies usually focus on a single second messenger, and the mechanisms and physiological significance of the cross-regulation between different nucleotide second messengers are often unclear. Here, we show that Shewanella putrefaciens can form biofilms in both nutrient-rich and nutrient-poor media. While both are controlled by c-di-GMP, the re...