Phylogenomics redefines the evolutionary history of mosquitoes

• 成果类型: Article
• 署名作者: Pierce, Mac P.; Worthington, Brian M.; Han, Shaolin; Ni, Xue-Bing; Liao, Yunshi; Shum, Marcus H.; Guan, Yi; Holmes, Edward C.; Lam, Tommy T.
• 署名单位: University of Hong Kong; Shanghai Jiao Tong University; University of Sydney
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.2519291122
• 发表日期: 2025-10-21
• 页码: e2519291122
• 关键词: mosquitoes; phylogenomics; EVOLUTION; diptera-culicidae; TREE; mitochondrial; dna; diversity; parasites; DYNAMICS; vectors; climate; lineage

摘要

Mosquitoes have a substantial impact on human and animal health, but their deeper evolutionary relationships have been difficult to resolve. We inferred a time-calibrated phylogenetic history of mosquitoes using conserved genome-wide markers from representatives of major lineages. Our analyses revealed that codon bias and positive selection in subfamily Anophelinae contributed to a substantial level of branch attraction bias between Anophelinae and outgroup taxa, which in our view has misled previous phylogenetic analyses of mosquitoes. Accounting for this systematic phylogenetic bias led to a revised view of mosquito evolution, including the nonmonophyly of subfamily Culicinae. Similarly, we dated the origin of mosquitoes to the mid-Cretaceous (similar to 106 Mya) and most extant genera to after the KPg boundary <66 Mya, 100 My younger than previous estimates and coincident with the origin of Plasmodium parasites. Our study provides a foundation for future analyses of the evolution of mosquito-borne disease.