2025

最新文章

• Localized tension-induced giant folding in unstructured elastic sheets AI翻译
  作者：Guo, Kexin; Sune, Marc; Kwok, Ming Li; Hsia, K. Jimmy; Liu, Mingchao; Vella, Dominic
  作者单位：Nanyang Technological University; University of Oxford; Nanyang Technological University; University of Birmingham
  摘要：Buckling in compression is the archetype of elastic instability: when compressed along its longest dimension, a thin structure such as a playing card will buckle out-of-plane accommodating the imposed compression without a significant change of length. However, recent studies have demonstrated that tension applied to sheets with microscopic structure leads to out-of-plane deformation in applications from groovy metasheets for multistable morphing to kirigami grippers. Here, we demonstrate that...
• Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis AI翻译
  作者：Jiang, Han-Wei; Gisriel, Christopher J.; Cardona, Tanai; Flesher, David A.; Brudvig, Gary W.; Ho, Ming-Yang
  作者单位：National Taiwan University; Yale University; University of Wisconsin System; University of Wisconsin Madison; University of London; Queen Mary University London; Yale University; National Taiwan University
  摘要：Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving organisms capable of oxygenic photosynthesis. However, and until recently, photosynthesis studies in thylakoid-free cyanobacteria were only possible in the model strain Gloeobacter violaceus, limiting our understanding of photosynthesis evolution. Here, report the isolation, biochemical characterization, cryo-EM structure, and phylogenetic analysis of photosystem I (PSI) from a recently discovered thylakoid...
• RNA sequencing analysis of viromes of Aedes albopictus and Aedes vexans collected from NEON sites AI翻译
  作者：Paull, Sara H.; Spurbeck, Rachel R.; Hasan, Nur A.; Brumfield, Kyle D.; Catlin, Lindsay A.; Netherland Jr, Michael J.; Smith, Anthony K.; Thibault, Katherine M.; Colwell, Rita R.
  作者单位：Battelle Memorial Institute; Battelle Memorial Institute
  摘要：Climate change is significantly impacting the geographic range of many animal species and their associated microorganisms, hence influencing emergence of vector- borne diseases. Mosquito- borne viruses represent a potential major reservoir of human pathogens, highlighting the need for improved understanding of ecological factors associated with variation in the mosquito viral community (virome). Here, a subtractive hybridization method coupled with RNAseq of individual mosquito specimens was u...
• Molecular insights into de novo small- molecule recognition by an intron RNA structure AI翻译
  作者：Liu, Tianshuo; Xu, Ling; Chung, Kevin; Sisto, Luke J.; Hwang, Jimin; Zhang, Chengxin; Van Zandt, Michael C.; Pyle, Anna Marie
  作者单位：Yale University; Howard Hughes Medical Institute; Yale University; Yale University
  摘要：Despite the promise of vastly expanding the druggable genome, rational design of RNA-targeting ligands remains challenging as it requires the rapid identification of hits and visualization of the resulting cocomplexes for guiding optimization. Here, we leveraged high-throughput screening, medicinal chemistry, and structural biology to identify a de novo splicing inhibitor against a large and highly folded fungal group I intron. High-resolution cryoEM structures of the intron in different ligan...
• Ultraviolet and biological effective dose observations at Gale Crater, Mars AI翻译
  作者：Viudez-Moreiras, Daniel; Zorzano, Maria- Paz; Lemmon, Mark T.; Fairen, Alberto G.; Saiz-Lopez, Alfonso; Smith, Michael D.
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Astrobiologia (INTA); Cornell University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC); National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center
  摘要：The incident ultraviolet (UV) irradiance on the surface of Mars is strongly sterilizing and plays a critical role in atmospheric and near- surface photochemistry. The Rover Environmental Monitoring Station (REMS) instrument, which includes the first UV sensor sent to Mars on board the Curiosity rover, has been measuring the UV irradiance at Gale Crater since 2012, providing ground- truth data regarding seasonal and short- term variability of the UV radiation at the surface of another planet. H...
• Material- to- system tailored multilayer- cyclic strategy toward practical atmospheric water harvesting AI翻译
  作者：Zhao, Yaxuan; Guan, Weixin; Wong, Yan Zhe; Lei, Chuxin; Wang, Yuyang; Liu, Xiaomeng; Yu, Guihua
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Solar-driven atmospheric water harvesting (AWH) presents a sustainable approach for freshwater production with sunlight as the sole energy input. To address challenges posed by diurnal moisture variations and diffusive sunlight, we present a system-wide approach that synergistically enhances moisture capture and solar energy utilization in an integrated water harvester. Moisture utilization at the bulk sorbent scale is improved through the hierarchical pore structure of scalable biomass gel sh...
• Linked nitrogen and carbon dynamics reveal distinct pools and patterns in a deep, weathered bedrock rhizosphere AI翻译
  作者：Crutchfield-Peters, Kelsey L.; Rempe, Daniella M.; Tune, Alison K.; Dawson, Todd E.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Texas System; University of Texas Austin
  摘要：Nitrogen is one of the most limiting nutrients to forest productivity worldwide. Recently, it has been established that diverse ecosystems source a substantial fraction of their water from weathered bedrock, leading to questions about whether root-driven nitrogen cycling extends into weathered bedrock as well. In this study, we specifically examined nitrogen dynamics using specialized instrumentation distributed across a 16 m weathered bedrock vadose zone (WBVZ) underlying an old growth forest...
• Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice-An unbiased functional study AI翻译
  作者：Yoon, Hongsup; Gerdes, Lisa Ann; Beigel, Florian; Sun, Yihui; Koevilein, Janine; Wang, Jiancheng; Kuhlmann, Tanja; Flierl-Hecht, Andrea; Haller, Dirk; Hohlfeld, Reinhard; Baranzini, Sergio E.; Wekerle, Hartmut; Peters, Anneli
  作者单位：University of Munich; University of Munich; University of Munich; University of Munich; University of California System; University of California San Francisco; University of Munster; Technical University of Munich; Handong Global University
  摘要：We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we compared gut microbial profiles in a cohort of 81 monozygotic twins discordant for MS. This approach allowed to minimize confounding effects by genetic and early environmental factors and identified over 50 differently abundant taxa with the majority of increased taxa within the Firmicutes. These included taxa previously described to be associated with...
• Linking energetic instability to compositional changes in biological communities AI翻译
  作者：Kadoya, Taku; Suzuki, Kenta; Terui, Akira
  作者单位：National Institute for Environmental Studies - Japan; RIKEN; Yokohama National University; University of North Carolina; University of North Carolina Greensboro
  摘要：The resilience of an ecological community informs us how it will respond to future environmental disturbances. However, the concept is rarely tested in the context of predicting biodiversity change, particularly at broad spatial and taxonomic scales. Here, we show that measures of instability derived from the resilience of the current state of community compositions greatly improve the predictability of biodiversity change. We applied energy landscape analysis (ELA) to community compositions o...
• MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes AI翻译
  作者：Nishio, Miki; Yamaguchi, Keiko; Otani, Junji; Yuguchi, Katsuya; Kohno, Daisuke; Sasaki, Tsutomu; Kitamura, Tadahiro; Shinohara, Masakazu; Soga, Tomoyoshi; Kawamura, Koichi; Sasaki, Atsuo T.; Oshima, Masashi; Hikasa, Hiroki; Woo, Minna; Sasaki, Takehiko; Nishina, Hiroshi; Nakao, Kazuwa; Maehama, Tomohiko; Suzuki, Akira
  作者单位：Kobe University; Gunma University; Kyoto University; Kobe University; Keio University; Keio University; Waseda University; University System of Ohio; University of Cincinnati; Hiroshima University; Jichi Medical University; University of Occupational & Environmental Health - Japan; University of Toronto; University of Toronto; University of Toronto; University Health Network Toronto; Institute of Science Tokyo; Kyoto University; Showa Medical University
  摘要：There is currently a global epidemic of obesity and obesity-related diseases such as type 2 diabetes due to decreased physical activity, excessive food intake, and/or genetic predisposition. The Hippo-YAP1 pathway has attracted attention as a potential therapeutic target because YAP1/TAZ activation in murine immature adipocytes in vitro suppresses their differentiation by inhibiting PPAR gamma activity.However, the role of YAP1 activation in mature adipocytes in vivo remains unclear. MOB1, who...