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作者：Chang, Seungwoo; Laureti, Luisa; Thrall, Elizabeth S.; Kay, Marguerite S.; Philippin, Gaelle; Jergic, Slobodan; Pages, Vincent; Loparo, Joseph J.
作者单位：Fordham University; Brandeis University; Harvard University; Harvard Medical School; UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; University of Wollongong
摘要：Processivity clamps mediate polymerase switching for translesion synthesis (TLS). All three Escherichia coli TLS polymerases interact with the (32 processivity clamp through a conserved clamp- binding motif (CBM), which is indispensable for TLS. Notably, Pol IV also interacts weakly with the rim of the clamp through non-CBM residues. Ablating this rim contact in cells results in selective sensitivity to DNA- damaging agents, raising the question how the rim contact contributes to TLS. Here, we...
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作者：Xu, Song'en; Hong, Jiaxin; Dongye, Meimei; Lin, Jiehao; Xue, Rongtao; Huang, Zhibin; Xu, Jin; Zhang, Yiyue; Leung, Anskar Yu- Hung; Shen, Juan; Zhang, Wenqing; Liu, Wei
作者单位：South China University of Technology; Sun Yat Sen University; Southern Medical University - China; University of Hong Kong; Guangdong Pharmaceutical University; Guangdong Pharmaceutical University
摘要：Approximately 30% of patients with myelodysplastic syndrome (MDS) progress to secondary acute myeloid leukemia (sAML) via accumulating gene mutations. Genomic analyses reveal a complex interplay among mutant genes, with co- occurring and mutually exclusive patterns. Hyperactivation of c-MYB and deficiency of PU.1 have been linked to myeloid disorders. We report a case of AML with concurrent PU.1 and c-MYB mutations, exhibiting early onset, high blast count, chemo- resistance, indicating high- ...
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作者：Liu, Shaoqing; Csillik, Ovidiu; Ordway, Elsa M.; Chang, Li - Ling; Longo, Marcos; Keller, Michael; Moorcroft, Paul R.
作者单位：Harvard University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; Wake Forest University; University of California System; University of California Los Angeles; State University System of Florida; Florida State University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Agriculture (USDA); United States Forest Service
摘要：forest carbon storage and forest ecosystem responses to climate variability and change. Previous studies have analyzed environmental drivers influencing spatial variation in canopy height at landscape- to- regional scales; however, far less is known about the environmental determinants underlying regional and global scale variation in forest canopy height. Using the canopy height metrics products from Global Ecosystem instrument specifically designed to characterize forest structure, we analyz...
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作者：Bachman, Julia L.; Kitcher, Sian R.; Vattino, Lucas G.; Beaulac, Holly J.; Chaves, M. Grace; Rivera, Israel Hernandez; Katz, Eleonora; Wedemeyer, Carolina; Weisz, Catherine J. C.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Harvard University; Harvard University Medical Affiliates; Massachusetts Eye & Ear Infirmary; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：Cochlear outer hair cells (OHCs) are electromotile and implicated in amplification of responses to sound that enhance sound sensitivity and frequency tuning. They send afferent information through glutamatergic synapses onto type II spiral ganglion neurons (SGNs). These synapses are weaker than those from cochlear inner hair cells onto type I SGN, suggesting that type II SGNs respond only to intense sound levels. OHCs also receive efferent innervation from medial olivocochlear (MOC) neurons. M...
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作者：Chan, San To; Fried, Eliot
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作者：Perault, Andrew I.; John, Amelia St.; Dumont, Ashley L.; Shopsin, Bo; Pironti, Alejandro; Torres, Victor J.
作者单位：St Jude Children's Research Hospital
摘要：Pathogenic Enterobacter species are of increasing clinical concern due to the multidrug- resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of Enterobacter virulence is limited, hindering the development of new prophylactics and therapeutics targeting infections caused by Enterobacter species. In this study, we assessed the virulence of contemporary clinical Enterobacter hormaechei isolates in a mouse model of intraperitoneal infection and use...
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作者：Straub, Verena M.; Barti, Benjamin; Tandar, Sebastian T.; Stevens, A. Floor; van Egmond, Noelle; van der Wel, Tom; Zhu, Na; Rueegger, Joel; van der Horst, Cas; Heitman, Laura H.; Li, Yulong; Stella, Nephi; van Hasselt, J. G. Coen; Katona, Istvan; van der Stelt, Mario
作者单位：Leiden University - Excl LUMC; Leiden University; Indiana University System; Indiana University Bloomington; Leiden University - Excl LUMC; Leiden University; Leiden University; Leiden University - Excl LUMC; Peking University; Peking University; University of Washington; University of Washington Seattle; HUN-REN; HUN-REN Institute of Experimental Medicine
摘要：While it is known that endocannabinoids (eCB) modulate multiple neuronal functions, the molecular mechanism governing their release and transport remains elusive. Here, we propose an on- demand release model, wherein the formation of microvesicles, a specific group of extracellular vesicles (EVs) containing the eCB, 2- arachidonoylglycerol (2- AG), is an important step. A coculture model system that combines a reporter cell line and neuronal cells revealed that neurons release EVs containing 2...
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作者：Avstrikova, Mariia; Rodriguez, Paula Milan; Burke, Sean M.; Hibbs, Ryan E.; Changeux, Jean-Pierre; Cecchini, Marco
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Diego; Universite PSL; College de France; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
摘要：The alpha 7 nicotinic acetylcholine receptor is a pentameric ligand- gated ion channel that plays an important role in neuronal signaling throughout the nervous system. Its implication in neurological disorders and inflammation has spurred the development of numerous compounds that enhance channel activation. However, the therapeutic potential of these compounds has been limited by the characteristically fast desensitization of the alpha 7 receptor. Using recent high- resolution structures fro...
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作者：Cotet, Miruna; Zhao, Wenjia Joyce; Krajbich, Ian
作者单位：University System of Ohio; Ohio State University; University of Warwick; University of California System; University of California Los Angeles; University System of Ohio; Ohio State University
摘要：A standard assumption in game theory is that decision- makers have preplanned strategies telling them what actions to take for every contingency. In contrast, nonstrategic decisions often involve an on- the- spot comparison process, with longer response times (RT) for choices between more similarly appealing options. If strategic decisions also exhibit these patterns, then RT might betray private information and alter game theory predictions. Here, we examined bargaining behavior to determine ...
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作者：Nguyen, Lien; Ajredini, Ramadan; Guo, Shu; Romano, Lisa E. L.; Tomas, Rodrigo F.; Bell, Logan R.; Ranum, Paul T.; Zu, Tao; Coronel, Monica Banez; Kelley, Chase P.; Redding-Ochoa, Javier; Nizamis, Evangelos; Melloni, Alexandra; Connors, Theresa R.; Gaona, Angelica; Thangaraju, Kiruphagaran; Pletnikova, Olga; Clark, H. Brent; Davidson, Beverly L.; Yachnis, Anthony T.; Golde, Todd E.; Lou, Xiangyang; Wang, Eric T.; Renton, Alan E.; Goate, Alison; Valdmanis, Paul N.; Prokop, Stefan; Troncoso, Juan C.; Hyman, Bradley T.; Ranum, Laura P. W.
作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Johns Hopkins University; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Minnesota System; University of Minnesota Twin Cities; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：Alzheimer's disease (AD) affects more than 10% of the population >= 65 y of age, but the underlying biological risks of most AD cases are unclear. We show anti-poly-glycine-arginine (a-polyGR) positive aggregates frequently accumulate in sporadic AD autopsy brains (45/80 cases). We hypothesize that these aggregates are caused by one or more polyGR-encoding repeat expansion mutations. We developed a CRISPR/deactivated-Cas9 enrichment strategy to identify candidate GR-encoding repeat expansion m...
