2025

最新文章

• Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancer AI翻译
  作者：Wang, Manli; Wang, Yiyun; Pan, Xiangyu; Wang, Bo; Wang, Yuying; Luo, Xiangmeng; Deng, Xiaofeng; Liu, Li; Chen, Xuelan; Zhai, Xiaoqian; Wu, Baohong; Zhang, Qi; Ren, Yifeng; Li, Jia; Li, Xiaoyu; Cao, Fujun; Yang, Yang; Deng, Xintong; Li, Runhong; Lu, Zhenghao; Tan, Ping; Chen, Jingyao; Li, Yan; Liu, Yanyang; Liu, Jiewei; Wang, Yuan; Deng, Hongxin; Su, Zhaoming; Wang, Weiya; Wang, Yongsheng; Yang, Shengyong; Zhao, Chengjian; Xue, Jianxin; Wei, Yuquan; Zhang, Kang; Na, Feifei; Liu, Yu; Chen, Chong
  作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Chengdu University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine; Sichuan University; Sichuan University; Macau University of Science & Technology; Sichuan University; Sichuan University; Tianfu Jincheng Laboratory; Sichuan University
  摘要：Immunotherapy has become the standard treatment for many types of cancers, but an increasing number of patients who initially respond to these treatments develop acquired immunotherapy resistance (AIR). Here, we recapitulated the entire process of immunotherapy from response to AIR in mice with non-small cell lung cancer (NSCLC). With implanted tumor organoids derived from these models and serial transplants, we demonstrated that tumor cell-intrinsic mechanisms contributed significantly to AIR...
• QnAs with David B. Lobell AI翻译
  作者：Williams, Sarah C. P.
• Revealing land control dynamics in emerging agricultural frontiers AI翻译
  作者：del Giorgio, Olivia; Baumann, Matthias; Kuemmerle, Tobias; de Waroux, Yann le Polain
  作者单位：McGill University; Humboldt University of Berlin; Humboldt University of Berlin; McGill University
  摘要：The expansion of commodity agriculture into tropical and subtropical woodlands degrades ecosystem functionality, biodiversity, and the livelihood base of millions of people. Understanding where and how agricultural frontiers emerge is thus important. Yet, existing monitoring approaches typically focus on mapping deforestation and do not capture the shifts in land access and ownership that lay the ground for agricultural expansion, thereby missing early stages of frontier development. We develo...
• Reply to Apanovich and Weeks: Exceptions exist, as recognized in the paper, but are too rare to challenge the original findings AI翻译
  作者：Eshel, Gidon; Flamholz, Avi I.; Shepon, Alon; Milo, Ron
  作者单位：Rockefeller University; Tel Aviv University; Weizmann Institute of Science
• Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA AI翻译
  作者：Iguchi, Eriko; Takai, Atsushi; Oe, Natsumi; Fujii, Yosuke; Omatsu, Mayuki; Takeda, Haruhiko; Shimizu, Takahiro; Maruno, Takahisa; Nakanishi, Yuki; Yoshinaga, Masanori; Maruyama, Takashi; Marusawa, Hiroyuki; Obama, Kazutaka; Takeuchi, Osamu; Seno, Hiroshi
  作者单位：Kyoto University; Kyoto University; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); Osaka Red Cross Hospital; Kyoto University
  摘要：Regnase- 1 is a ribonuclease that regulates inflammation in immune cells by degrading cytokine mRNA. Regnase- 1 was identified as one of the frequently mutated genes in the inflamed colorectal epithelium of patients with ulcerative colitis; however, its significance in intestinal epithelial cells during the tumorigenic process remains unknown. Therefore, we developed an ApcMin/+ mouse model lacking Regnase- 1 in intestinal epithelia. Regnase- 1 deletion significantly enhanced colon tumor growt...
• CACNA1D is a circadian gene and causes familial advanced sleep phase AI翻译
  作者：Webb, John M.; Abderemane-Ali, Fayal; Ashbrook, Liza; Ma, Mingyang; Nibber, Neha; Zou, Xianlin; Yamazaki, Maya; Wohler, Elizabeth; Sobreira, Nara; Minor Jr, Daniel L.; Fu, Ying - Hui; Ptacek, Louis J.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Johns Hopkins University; Johns Hopkins Medicine; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California San Francisco
  摘要：Familial advanced sleep phase (FASP) is a heritable human sleep trait characterized by early sleep onset and offset times. We have identified five variants in five different families in the human voltage- gated calcium channel subunit alpha1 D (CACNA1D) that cosegregate with FASP. The variants in CACNA1D lead to altered channel dynamics in vitro. A mouse model of the E427K variant has a normal circadian period under constant darkness but displays altered phase shifts in response to light in th...
• Microscale technologies for tissue engineering and biology (vol 103, 2480-2487, 2006). AI翻译
  作者：Khademhosseini, Ali; Langer, Robert; Borenstein, Jeffrey; Vacanti, Joseph P.
• The proofreading mechanism of the human leading- strand DNA polymerase ε holoenzyme AI翻译
  作者：Wang, Feng; He, Qing; O'Donnell, Michael E.; Li, Huilin
  作者单位：Van Andel Institute; Rockefeller University; Rockefeller University; Howard Hughes Medical Institute
  摘要：The eukaryotic leading-strand DNA polymerase epsilon(Pol epsilon) is a dual-function enzyme with a proofreading 3 '-5 ' exonuclease (exo) site located 40 & Aring; from the DNA synthesizing pol site. Errors in Pol epsilon proofreading can cause various mutations, including C-to-G trans-versions, the most prevalent mutation in cancers and genetic diseases. Pol epsilon interacts with all three subunits of the PCNA ring to assemble a functional holoenzyme. Despite previous studies on proofreading ...
• Viral and host network analysis of the human cytomegalovirus transcriptome in latency AI翻译
  作者：Collins-McMillen, Donna; Pessoa, Diogo De Oliveira; Zarrella, Kristen; Parkins, Christopher J.; Daily, Michael; McKinzey, David R.; Moorman, Nathaniel J.; Kamil, Jeremy P.; Caposio, Patrizia; Padi, Megha; Goodrum, Felicia D.
  作者单位：University of Arizona; University of Arizona; University of Arizona; Arizona Center Cancer Care; Oregon Health & Science University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Louisiana State University System; Louisiana State University Health Sciences Center at Shreveport; University of Arizona; University of Arizona
  摘要：The human cytomegalovirus (HCMV) UL135 and UL138 genes play opposing roles regulating latency and reactivation in CD34+ human progenitor cells. We designed an RNA sequencing study to compare the transcriptional profile of HCMV infection in the presence and absence of these genes using the Tohoku Hospital Pediatrics-1 (THP-1) monocytic cell line model for latency. Relative to primary cell models, THP-1 cells offer the strength of a homogenous population that uniformly silences gene expression a...
• Experimental and theoretical evidence of universality in superfluid vortex reconnections AI翻译
  作者：Stasiak, Piotr Z.; Xing, Yiming; Alihosseini, Yousef; Barenghi, Carlo F.; Baggaley, Andrew; Guo, Wei; Galantucci, Luca; Krstulovic, Giorgio
  作者单位：Newcastle University - UK; State University System of Florida; Florida State University; State University System of Florida; Florida State University; Florida A&M University; Lancaster University; Centre National de la Recherche Scientifique (CNRS); Universite Cote d'Azur; Observatoire de la Cote d'Azur
  摘要：The minimum separation between reconnecting vortices in fluids and superfluids obeys a universal scaling law with respect to time. The prereconnection and the postreconnection prefactors of this scaling law are different, a property related to irreversibility and to energy transfer and dissipation mechanisms. In the present work, we determine the temperature dependence of these prefactors in superfluid helium from experiments and a numeric model which fully accounts for the coupled dynamics of...