2025

最新文章

• Fast Interpretable Greedy-Tree Sums AI翻译
  作者：Tan, Yan Shuo; Singh, Chandan; Nasseri, Keyan; Agarwal, Abhineet; Duncan, James; Ronen, Omer; Epland, Matthew; Kornblith, Aaron; Yu, Bin
  作者单位：National University of Singapore; University of California System; University of California Berkeley; Microsoft; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Modern machine learning has achieved impressive prediction performance, but often sacrifices interpretability, a critical consideration in high-stakes domains such as medicine. In such settings, practitioners often use highly interpretable decision tree models, but these suffer from inductive bias against additive structure. To overcome this bias, we propose Fast Interpretable Greedy-Tree Sums (FIGS), which generalizes the Classification and Regression Trees (CART) algorithm to simultaneously ...
• Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering AI翻译
  作者：Liao, Yunji; Ma, Hang; Wang, Zhenyu; Wang, Shusheng; He, Yang; Chang, Yunsong; Zong, Huifang; Tang, Haoneng; Wang, Lei; Ke, Yong; Cai, Huiyu; Li, Ping; Tang, Jian; Chen, Hua; Drelich, Aleksandra; Peng, Bi-Hung; Hsu, Jason; Tat, Vivian; Tseng, Chien-Te K.; Song, Jingjing; Yuan, Yunsheng; Wu, Mingyuan; Liu, Junjun; Yue, Yali; Zhang, Xiaoju; Wang, Ziqi; Yang, Li; Li, Jing; Ni, Xiaodan; Li, Hongshi; Xiang, Yuning; Bian, Yanlin; Zhang, Baohong; Yin, Haiyang; Dimitrov, Dimiter S.; Gilly, John; Han, Lei; Jiang, Hua; Xie, Yueqing; Zhu, Jianwei
  作者单位：Shanghai Jiao Tong University; Mila Quebec Artificial Intelligence Institute; University of Quebec; University of Quebec Montreal; Universite de Montreal; HEC Montreal; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Zhengzhou University; Zhengzhou University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：The rapid evolution of the viral genome has led to the continual generation of new variants of SARS- CoV-2. Developing antibody drugs with broad- spectrum and high efficiency is a long- term task. It is promising but challenging to develop therapeutic neutralizing antibodies (nAbs) through in vitro evolution based on antigen-antibody binding interactions. From an early B cell antibody repertoire, we isolated antibody 8G3 that retains its nonregressive neutralizing activity against Omicron BA.1...
• Light's hidden power: Vacuum fluctuations reshape superconductivity from within AI翻译
  作者：Nova, T. F.; Caviglia, A. D.
  作者单位：University of Geneva
• The present and future of peer review: Ideas, interventions, and evidence AI翻译
  作者：Aczel, Balazs; Barwich, Ann - Sophie; Diekman, Amanda B.; Fishbach, Ayelet; Goldstone, Robert L.; Gomez, Pablo; Gundersen, Odd Erik; Hippel, Paul T. von; Holcombe, Alex O.; Lewandowsky, Stephan; Nozari, Nazbanou; Pestilli, Franco; Ioannidis, John P. A.
  作者单位：Eotvos Lorand University; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Chicago; Skidmore College; Norwegian University of Science & Technology (NTNU); University of Texas System; University of Texas Austin; University of Sydney; University of Bristol; University of Potsdam; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Stanford University; Stanford University; Stanford University; Stanford University
  摘要：What is wrong with the peer review system? Is peer review sustainable? Useful? What other models exist? These are central yet contentious questions in today's academic discourse. This perspective critically discusses alternative models and revisions to the peer review system. The authors highlight possible changes to the peer review system, with the goal of fostering further dialog among the main stakeholders, including producers and consumers of scientific research. Neither our list of identi...
• New evidence for early Indian Ocean trade routes into the South African interior AI翻译
  作者：Antonites, Alexander; Antonites, Annie R.; Peterson, Christian E.; Hopf, Tyron; Ndlovu, Ndukuyakhe
  作者单位：University of Pretoria; University of Hawaii System; University of Hawaii Manoa; University of Pretoria
  摘要：The rise and spread of ancient Indian Ocean Rim (IOR) trade networks profoundly impacted southern Africa. Control over this trade played a critical role in the rise and maintenance of complex societies of the second millennium CE such as Mapungubwe and Great Zimbabwe. While the African origins of this trade lie in the first millennium CE, understanding its earliest phases and subsequent development in the far south has been hampered by a general paucity of research. The recovery of Persian Gul...
• Enzymes in a human cytoplasm model organize into submetabolon complexes AI翻译
  作者：Russell, Premila P. Samuel; Rickard, Meredith M.; Pogorelov, Taras V.; Gruebele, Martin
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; Washington University (WUSTL); Saint Louis University; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Enzyme-enzyme interactions are fundamental to the function of cells. Their atomistic mechanisms remain elusive mainly due to limitations of in- cell measurements. We address this challenge by atomistically modeling, for a total of approximate to 80 mu s, a slice of the human cell cytoplasm that includes three successive enzymes along the glycolytic path(PGK), and phosphoglycerate mutase (PGM). We tested the model for nonspecific protein stickiness, an artifact of current atomistic force fields...
• Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma AI翻译
  作者：Ren, Jun; Amoozgar, Zohreh; Uccello, Taylor P.; Lei, Pin - Ji; Zhao, Yuhui; Ho, William W.; Huang, Peigen; Kardian, Alisha; Mack, Stephen C.; Duda, Dan G.; Xu, Lei; Jain, Rakesh K.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Baylor College of Medicine; AstraZeneca; Sanofi-Aventis; Sanofi USA; Guangdong Medical University; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN)
  摘要：Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led to a better understanding of EPN subtypes and revealed a critical role of oncogenes ZFTA-RELA fusion and EPHB2 in supratentorial ependymoma (ST-EPN). However, the immune system's role in tumor progression and response to therapy remains poorly understood. New treatments for various molecular subtypes of EPN are desperately needed. Using ST- EPN-ZF...
• Expert navigators deploy rational complexity-based decision precaching for large- scale real- world planning AI翻译
  作者：Velasco, Pablo Fernandez; Griesbauer, Eva- Maria; Brunec, Iva K.; Morley, Jeremy; Manley, Ed; Mcnamee, Daniel C.; Spiers, Hugo J.
  作者单位：University of London; University College London; University of York - UK; University of Pennsylvania; University of Leeds; University of London; University College London
  摘要：Efficient planning is a distinctive hallmark of intelligence in humans, who routinely make rapid inferences over complex world contexts. However, studies investigating how humans accomplish this tend to focus on naive participants engaged in simplistic tasks with small state spaces, which do not reflect the intricacy, ecological validity, and human specialization in real- world planning. In this study, we examine the street- by- street route planning of London taxi drivers navigating across mo...
• Estimating realized relatedness in free- ranging macaques by inferring identity- by- descent segments AI翻译
  作者：Freudiger, Annika; Jovanovic, Vladimir M.; Huang, Yilei; Snyder- Mackler, Noah; Conrad, Donald F.; Miller, Brian; Montague, Michael J.; Westphal, Hendrikje; Stadler, Peter F.; Bley, Stefanie; Horvath, Julie E.; Brent, Lauren J. N.; Platt, Michael L.; Ruiz-Lambides, Angelina; Tung, Jenny; Nowick, Katja; Ringbauer, Harald; Widdig, Anja
  作者单位：Leipzig University; Max Planck Society; Free University of Berlin; Max Planck Society; Leipzig University; Leipzig University; Arizona State University; Arizona State University-Tempe; Oregon Health & Science University; Oregon National Primate Research Center; University of Pennsylvania; Max Planck Society; University of Vienna; Universidad Nacional de Colombia; The Santa Fe Institute; North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; University of Exeter; University of Pennsylvania; University of Pennsylvania; Duke University; Duke University; Duke University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
  摘要：Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of identical- by- descent DNA segments (IBD) yield the most precise relatedness estimates. Here, we leverage different methods for estimating IBD segments from low- depth whole genome resequencing data to demonstrate the fea-sibility and value of resolving fine- scaled gradients of re...
• The proteome is a terminal electron acceptor AI翻译
  作者：Flamholz, Avi, I; Goyal, Akshit; Fischer, Woodward W.; Newman, Dianne K.; Phillips, Rob
  作者单位：California Institute of Technology; Massachusetts Institute of Technology (MIT); Tata Institute of Fundamental Research (TIFR); International Centre for Theoretical Sciences, Bengaluru; California Institute of Technology; California Institute of Technology
  摘要：Microbial metabolism is impressively flexible, enabling growth even when available nutrients differ greatly from biomass in redox state. Escherichia coli, for example, rearranges its physiology to grow on reduced and oxidized carbon sources through several forms of fermentation and respiration. To understand the limits on and evolutionary consequences of this metabolic flexibility, we developed a coarse-grained mathematical framework coupling redox chemistry with principles of cellular resourc...