2025

最新文章

• Pseudogap in electron-doped cuprates: Strong correlation leading to band splitting AI翻译
  作者：Horio, Masafumi; Sakai, Shiro; Suzuki, Hakuto; Nonaka, Yosuke; Hashimoto, Makoto; Lu, Donghui; Shen, Zhi-Xun; Ohgi, Taro; Konno, Takuya; Adachi, Tadashi; Koike, Yoji; Imada, Masatoshi; Fujimori, Atsushi
  作者单位：University of Tokyo; University of Tokyo; RIKEN; Tohoku University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Tohoku University; Sophia University; Waseda University; National Tsing Hua University
  摘要：The pseudogap phenomena have been a long-standing mystery of the cuprate high- temperature superconductors. The pseudogap in the electron-doped cuprates has been attributed to band folding due to antiferromagnetic (AFM) long-range order or shortrange correlation. We performed an angle-resolved photoemission spectroscopy study of the electron-doped cuprates Pr1.3-xLa0.7CexCuO4 showing spin-glass, disordered AFM behaviors, and superconductivity at low temperatures and, by measurements with fine ...
• Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae AI翻译
  作者：Mahoney, Brendan J.; Lyman, Lindsey R.; Ford, Jordan; Soule, Jess; Cheung, Nicole A.; Goring, Andrew K.; Ellis-Guardiola, Kat; Collazo, Michael J.; Cascio, Duilio; Ton-That, Hung; Schmitt, Michael P.; Clubb, Robert T.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; US Food & Drug Administration (FDA); Center for Biologics Evaluation & Research (CBER); University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. Corynebacterium diphtheriae causes the life- threatening respiratory disease diphtheria and captures hemoglobin for iron scavenging using the surface- displayed receptor HbpA. Here, we show using X- ray crystallography, NMR, and in situ binding measurements that C. diphtheriae selectively captures iron- loaded hemoglobin by partially ensconcin...
• Liquid- nano- liquid interface-oriented anisotropic encapsulation AI翻译
  作者：Zhan, Yating; Huang, Xirui; Liu, Minchao; Lin, Runfeng; Yu, Hongyue; Kou, Yufang; Xing, Enyun; Elzatahry, Ahmed A.; Mady, Mohamed F.; Zhao, Dongyuan; Zhao, Tiancong; Li, Xiaomin
  作者单位：Fudan University; University of Houston System; University of Houston; Qatar University
  摘要：Emulsion interface engineering has been widely employed for the synthesis of nanomaterials with various morphologies. However, the instability of the liquid-liquid interface and uncertain interfacial interactions impose significant limitations on controllable fabrications. Here, we developed a liquid- nano- liquid interface-oriented anisotropic encapsulation strategy for fabricating asymmetric nanohybrids. Specifically, functional nanoparticles such as magnetic nanoparticles, lanthanide fluore...
• Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling AI翻译
  作者：Uwase, Grace; Luthra, Priya; Vogel, Olivia A.; Batra, Jyoti; La Rosa, Bruno A.; Sheehan, Kathleen C. F.; Khatavkar, Oam; Payton, Jacqueline E.; Davey, Robert A.; Krogan, Nevan J.; Basler, Christopher F.; Leung, Daisy W.; Amarasinghe, Gaya K.
  作者单位：Washington University (WUSTL); Saint Louis University; Icahn School of Medicine at Mount Sinai; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Boston University; Saint Louis University; Washington University (WUSTL)
  摘要：Ebola virus (EBOV) is a nonsegmented, negative-sense virus (NNSV) with a single-stranded RNA genome. EBOV encodes for a limited number of proteins and thus depends on host factors to facilitate viral replication and pathogenesis. Of the virus-encoded proteins, multifunctional EBOV VP35 (eVP35) is necessary for host immune evasion and viral RNA synthesis. Previous proteomics studies identified an interaction between eVP35 and the host E3 ubiquitin ligase Mindbomb 2 (MIB2). Here, we show how an ...
• Sizing the largest ocean waves using the SWOT mission AI翻译
  作者：Ardhuin, Fabrice; Postec, Taina; Accensi, Mickael; Piolle, Jean-Francois; Dodet, Guillaume; Passaro, Marcello; De Carlo, Marine; Husson, Romain; Guitton, Gilles; Collard, Fabrice
  作者单位：Ifremer; Universite de Bretagne Occidentale; Institut Universitaire Europeen de la Mer (IUEM); Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Technical University of Munich
  摘要：Winds generate waves over the oceans with a wide range of properties. The largest wave heights and periods are important parameters in the design of marine structures. Extreme waves also play an outsize role in air-sea fluxes and coastal dynamics, and leave imprints on seismic and sediment records. Rare events have so far escaped measurements, with few wave heights from satellite altimeters exceeding 16 m, and no associated measurement of wave periods. Here, we use swells radiated from storms ...
• From molecular damage and viscoelasticity to interfacial fracture in soft polymer networks: Insights from mechanochemistry AI翻译
  作者：Arrowood, Anthony; Frazier, Jackson; Ciccotti, Matteo; Sanoja, Gabriel E.
  作者单位：University of Texas System; University of Texas Austin; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Sorbonne Universite
  摘要：Many soft, tough materials have emerged in recent years, paving the way for advances in wearable electronics, soft robotics, and flexible displays. However, understanding the interfacial fracture behavior of these materials remains a significant challenge, owing to the difficulty of quantifying the respective contributions from viscoelasticity and damage to energy dissipation ahead of cracks. This work aims to address this challenge by labeling a series of polymer networks with fluorogenic mec...
• A geometric condition for robot-swarm cohesion and cluster-flock transition AI翻译
  作者：Casiulis, Mathias; Arbel, Eden; van Waes, Charlotte; Lahini, Yoav; Martiniani, Stefano; Oppenheimer, Naomi; Zion, Matan Yah Ben
  作者单位：New York University; New York University; Tel Aviv University; Radboud University Nijmegen; New York University
  摘要：We present a geometric design rule for size-controlled clustering of self-propelled particles. We show that active particles that tend to rotate under an external force have an intrinsic, signed parameter with units of curvature which we call curvity, that can be derived from first principles. Experiments with robots and numerical simulations show that properties of individual robots (radius and curvity) control pair cohesion in a binary system, and the stability of flocking and self-limiting ...
• Bridging feeling and motion: Insula-premotor dynamics in the processing of action vitality forms AI翻译
  作者：Di Cesare, Giuseppe; Koush, Yury; Zeidman, Peter; Sciutti, Alessandra; Friston, Karl; Rizzolatti, Giacomo
  作者单位：University of Parma; Istituto Italiano di Tecnologia - IIT; Skolkovo Institute of Science & Technology; University of London; University College London; Consiglio Nazionale delle Ricerche (CNR)
  摘要：Typically, people perform actions in a valenced-positive or negative-way, depending on their attitudes or desires. These forms of action are named vitality forms (VFs). While it is well established that action goals are mediated by a parieto-frontal network, less is known about the processing of VFs. Recent fMRI studies suggest that the insula (INS)-and its connections with the parieto-frontal circuit-plays a crucial role in VFs processing. However, a key question remains: How does our interna...
• Female membrane proteins regulate postmating ovulation in Drosophila melanogaster by ovulin-dependent and-independent pathways AI翻译
  作者：Yang, Mengye; White, Melissa A.; Findlay, Geoffrey D.; Vignogna, Ryan C.; Apger-McGlaughon, Jennifer; Clark, Nathan L.; Choi, Jae Young; Fromme, J. Christopher; Wolfner, Mariana F.
  作者单位：Cornell University; College of the Holy Cross; Cornell University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Kansas; Cornell University
  摘要：Ovulation is an intricate process that is essential for reproductive success. In Drosophila melanogaster, ovulation increases after mating. This increase is initiated by the male seminal fluid protein ovulin and is executed by female pathways, including octopamine (OA) neuronal signaling. Despite OA signaling's central role in ovulation regulation, the broader molecular landscape underlying female control of ovulation remains poorly understood. Here, using ovulin as a probe, we performed evolu...
• A general genome editing strategy using CRISPR lipid nanoparticle spherical nucleic acids AI翻译
  作者：Han, Zhenyu; Huang, Chi; Luo, Taokun; Mirkin, Chad A.
  作者单位：Northwestern University; Northwestern University
  摘要：Genome editing with CRISPR-Cas systems hold promise for treating a wide range of genetic disorders and cancers. However, efficient delivery of genome editors remains challenging due to the requirement for the simultaneous delivery or intracellular generation of Cas proteins, guide RNAs, and, in some applications, donor DNAs. Furthermore, the immunogenicity and toxicity of delivery vehicles can limit the safety and efficacy of genetic medicines. Here, we combine two nucleic acid delivery approa...