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作者：Fiscella, Kevin
作者单位：University of Rochester
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作者：Gailleton, Romain; Mathew, Nimitha R.; Reusch, Laura; Schon, Karin; Scharf, Lydia; Stromberg, Anneli; Cvjetkovic, Andrea; Aziz, Luaay; Hellgren, Johan; Tang, Ka-Wei; Bemark, Mats; Angeletti, Davide
作者单位：University of Gothenburg; Sahlgrenska University Hospital; Sahlgrenska University Hospital; University of Gothenburg; University of Gothenburg; Sahlgrenska University Hospital; Lund University; SciLifeLab; University of Gothenburg
摘要：The nasal mucosa is the first immunologically active site that respiratory viruses encounter and establishing immunity at the initial point of pathogen contact is essential for preventing viral spread. Influenza A virus (IAV) in humans preferentially replicates in the upper respiratory tract (URT) but mouse models of infection result in lower respiratory tract infection. Here, we optimize IAV inoculation to enhance replication in the nasal turbinate (NT) and study local B cell immunity. We dem...
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作者：Mychack, Aaron; Evans, Dwayne; Gilles, Tarah; James, Michael J.; Walker, Suzanne
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University; Harvard Medical School
摘要：Staphylococcus aureus is a Gram-positive pathogen responsible for numerous antibiotic-resistant infections. Identifying vulnerabilities in S. aureus is crucial for developing new antibiotics to treat these infections. With this in mind, we probed the function of GdpS, a conserved Staphylococcal membrane protein containing a cytoplasmic GGDEF domain. These domains are canonically involved in cyclic-di-GMP signaling processes, but S. aureus is not known to make cyclic-di-GMP. Using a transposon ...
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作者：Ruwe, Hannes; Spallek, Thomas
作者单位：University of Gottingen
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作者：Cohen, Samantha S.; Ngo, Chi T.; Olson, Ingrid R.; Newcombe, Nora S.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Max Planck Society
摘要：Pattern separation, or distinguishing similar experiences from one another, and pattern completion, in which components of an experience prompt retrieval or forgetting of an event pattern as a unit, are essential components of episodic memory. However, these two components are sometimes described as opposite ends of a continuum and sometimes described as independent processes. Here, we examined the relations between the two processes for the same events in children between 4 and 7 y. Mnemonic ...
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作者：Zhu, Qianru; Yu, Chuao; Chen, Yiquan; Luo, Wei; Li, Meng; Zou, Jianhua; Xiao, Fan; An, Soohwan; Saiding, Qimanguli; Tao, Wei; Kong, Na; Xie, Tian
作者单位：Hangzhou Normal University; Zhejiang University; Liangzhu Laboratory; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
摘要：Pancreatic ductal adenocarcinoma (PDAC) is notoriously immune-resistant, limiting the clinical efficacy of single-agent immune modulators and thereby necessitating the exploration of multimodal immunotherapy combinations. Traditional approaches combining conventional immune checkpoint inhibitors with neoantigen vaccines have shown some promise in treating PDAC but are often compromised by intratumoral T lymphocyte exhaustion and systemic toxicity. Hence, novel approaches are needed to address ...
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作者：Zhu, Ruijie; Zhang, Zhaoying; Zhang, Naichi; Zhong, Huan; Zhou, Fanqi; Zhang, Xiao; Liu, Cun; Huang, Yingnan; Yuan, Yuan; Wang, Yujun; Li, Chengjun; Shi, Huahong; Rillig, Matthias C.; Dang, Fei; Ren, Hongqiang; Zhang, Yongguang; Xing, Baoshan
作者单位：Nanjing University; Nanjing University; Nanjing Normal University; Nanjing University; Nanjing University; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guangzhou University; Free University of Berlin; University of Massachusetts System; University of Massachusetts Amherst
摘要：Understanding how ecosystems respond to ubiquitous microplastic (MP) pollution is crucial for ensuring global food security. Here, we conduct a multiecosystem meta-analysis of 3,286 data points and reveal that MP exposure leads to a global reduction in photosynthesis of 7.05 to 12.12% in terrestrial plants, marine algae, and freshwater algae. These reductions align with those estimated by a constructed machine learning model using current MP pollution levels, showing that MP exposure reduces t...
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作者：Kurnosov, Arkady; Lubchenko, Vassiliy
作者单位：University of Houston System; University of Houston; Wesleyan University; University of Houston System; University of Houston; University of Houston System; University of Houston
摘要：We argue that the dominant charge carrier in glassy semiconducting alloys is a compound particle in the form of an electron or hole bound to an intimate pair of topological lattice defects; the particle is similar to the polaron solution of the Su-Schrieffer-Heeger Hamiltonian. The spatial component of the density of states for these special polarons is determined by the length scale of spatial modulation of electronegativity caused by a separate set of standalone topological defects. The latt...
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作者：Patel, Dhruv; Roy, Avik; Kundu, Madhuchhanda; Jana, Malabendu; Luan, Chi-Hao; Gonzalez, Frank J.; Pahan, Kalipada
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作者：Grossman, Ethan L.; Barney, Bryce B.; Sun, Zeyang; Henkes, Gregory A.; Gao, Yang; Joachimski, Michael M.
作者单位：Texas A&M University System; Texas A&M University College Station; State University of New York (SUNY) System; Stony Brook University; University of Erlangen Nuremberg
